Ciliary landscape (WP4352)

Ciliary landscape pathway - according to Boldt et al. 2016 - was constructed using the results of affinity proteomics for 217 proteins with known or suspected involvement in ciliary function, resulting in a landscape of 1319 proteins and 4905 interactions of which the most important are shown here (derived from Figure 1). Ciliary function is impaired in a wide spectrum of diseases (ciliopathies) including polycystic kidney disease, Usher syndrome, Bardet-Biedl syndrome, Meckel-Gruber syndrome, and Jeune syndrome.
last edited

Authors

Fehrhart and Khanspers

Cited In

Organism

Homo sapiens

Communities

Annotations

Disease Ontology: ciliopathy

Pathway Ontology: transport pathway

Participants

Label Type Compact Identifier
RPGR GeneProduct ensembl:ENSG00000156313
DCAF11 GeneProduct ensembl:ENSG00000100897
DYNLL1 GeneProduct ensembl:ENSG00000088986
SPATA7 GeneProduct ensembl:ENSG00000042317
H3F3A GeneProduct ensembl:ENSG00000163041
COPS4 GeneProduct ensembl:ENSG00000138663
IFT122 GeneProduct ensembl:ENSG00000163913
HDAC1 GeneProduct ensembl:ENSG00000116478
TFAP2B GeneProduct ensembl:ENSG00000008196
CLT GeneProduct None
TFAP2D GeneProduct ensembl:ENSG00000008197
DCAF7 GeneProduct ensembl:ENSG00000136485
TFAP2C GeneProduct ensembl:ENSG00000087510
HDAC2 GeneProduct ensembl:ENSG00000196591
BBIP1 GeneProduct ensembl:ENSG00000214413
SNAP29 GeneProduct ensembl:ENSG00000099940
COPS7B GeneProduct ensembl:ENSG00000144524
GLA GeneProduct ensembl:ENSG00000102393
DYNLL2 GeneProduct ensembl:ENSG00000264364
IFT52 GeneProduct ensembl:ENSG00000101052
MFAP1 GeneProduct ensembl:ENSG00000140259
VPS4A GeneProduct ensembl:ENSG00000132612
NDUFA9 GeneProduct ensembl:ENSG00000139180
RHBDD2 GeneProduct ensembl:ENSG00000005486
MCM2 GeneProduct ensembl:ENSG00000073111
MCM3 GeneProduct ensembl:ENSG00000112118
CNOT10 GeneProduct ensembl:ENSG00000182973
LZTFL1 GeneProduct ensembl:ENSG00000163818
TFAP2E GeneProduct ensembl:ENSG00000116819
MKS1 GeneProduct ensembl:ENSG00000011143
YAP1 GeneProduct ensembl:ENSG00000137693
RBM14 GeneProduct ensembl:ENSG00000239306
DVL3 GeneProduct ensembl:ENSG00000161202
CD2BP2 GeneProduct ensembl:ENSG00000169217
TSSC1 GeneProduct ensembl:ENSG00000032389
CNOT1 GeneProduct ensembl:ENSG00000125107
BBS9 GeneProduct ensembl:ENSG00000122507
APC GeneProduct ensembl:ENSG00000134982
MCM9 GeneProduct ensembl:ENSG00000111877
CEP170 GeneProduct ensembl:ENSG00000143702
CBS GeneProduct ensembl:ENSG00000160200
COPS2 GeneProduct ensembl:ENSG00000166200
UBE2D2 GeneProduct ensembl:ENSG00000131508
NUP88 GeneProduct ensembl:ENSG00000108559
CNOT6L GeneProduct ensembl:ENSG00000138767
CTBP2 GeneProduct ensembl:ENSG00000175029
EXOC8 GeneProduct ensembl:ENSG00000116903
CTSA GeneProduct ensembl:ENSG00000064601
CEP97 GeneProduct ensembl:ENSG00000182504
ARFGAP3 GeneProduct ncbigene:26286
IFT43 GeneProduct ensembl:ENSG00000119650
TFAP2A GeneProduct ensembl:ENSG00000137203
IFT27 GeneProduct ensembl:ENSG00000100360
RAB3IL1 GeneProduct ensembl:ENSG00000167994
MCM8 GeneProduct ensembl:ENSG00000125885
TMED1 GeneProduct ensembl:ENSG00000099203
SNRPB2 GeneProduct ensembl:ENSG00000125870
LCA5 GeneProduct ensembl:ENSG00000135338
POM121 GeneProduct ensembl:ENSG00000196313
MCM5 GeneProduct ensembl:ENSG00000100297
TNKS1BP1 GeneProduct ensembl:ENSG00000149115
NUP133 GeneProduct ensembl:ENSG00000069248
COPS5 GeneProduct hgnc.symbol:COPS5
EFTUD2 GeneProduct ensembl:ENSG00000108883
MCM4 GeneProduct ensembl:ENSG00000104738
IFT46 GeneProduct ensembl:ENSG00000118096
ARHGDIA GeneProduct ensembl:ENSG00000141522
WEE1 GeneProduct ensembl:ENSG00000166483
COPS8 GeneProduct ensembl:ENSG00000198612
RAB2A GeneProduct ensembl:ENSG00000104388
UQCC1 GeneProduct ensembl:ENSG00000101019
CTNNB1 GeneProduct ensembl:ENSG00000168036
LSM4 GeneProduct ensembl:ENSG00000130520
NDUFA5 GeneProduct ensembl:ENSG00000128609
CCDC40 GeneProduct ensembl:ENSG00000141519
COPS6 GeneProduct ensembl:ENSG00000168090
MCM10 GeneProduct ensembl:ENSG00000065328
RAB14 GeneProduct ensembl:ENSG00000119396
MCM7 GeneProduct ensembl:ENSG00000166508
CREBBP GeneProduct ensembl:ENSG00000005339
RAB21 GeneProduct ensembl:ENSG00000080371
ERF GeneProduct ensembl:ENSG00000105722
USH1C GeneProduct ensembl:ENSG00000006611
NINL GeneProduct ensembl:ENSG00000101004
RQCD1 Protein uniprot:D5MQE1
IFT74 GeneProduct ensembl:ENSG00000096872
CAMK2A GeneProduct ensembl:ENSG00000070808
DNPEP GeneProduct ensembl:ENSG00000123992
NFKB1 GeneProduct ensembl:ENSG00000109320
IFT81 GeneProduct ensembl:ENSG00000122970
IFT57 GeneProduct ensembl:ENSG00000114446
CDR2 GeneProduct ensembl:ENSG00000140743
MSH2 GeneProduct ensembl:ENSG00000095002
IFT20 GeneProduct ensembl:ENSG00000109083
COPS3 GeneProduct ensembl:ENSG00000141030
IFT140 GeneProduct ensembl:ENSG00000187535
COPS1 GeneProduct None
EHBP1 GeneProduct ensembl:ENSG00000115504
CDH23 GeneProduct ensembl:ENSG00000107736
ARL8B GeneProduct ensembl:ENSG00000134108
MCM6 GeneProduct ensembl:ENSG00000076003
CLUAP1 GeneProduct ensembl:ENSG00000103351
ACSL3 GeneProduct ensembl:ENSG00000123983
NUDC GeneProduct ensembl:ENSG00000090273
DGKE GeneProduct ensembl:ENSG00000153933
AIMP1 GeneProduct ensembl:ENSG00000164022
RABEP2 GeneProduct ensembl:ENSG00000177548
GDI1 GeneProduct ensembl:ENSG00000203879
SSNA1 GeneProduct ensembl:ENSG00000176101
ECHS1 GeneProduct ensembl:ENSG00000127884
TTC8 GeneProduct ensembl:ENSG00000165533
EXOSC9 GeneProduct ensembl:ENSG00000123737
COPS7A GeneProduct ensembl:ENSG00000111652
WNK1 GeneProduct ensembl:ENSG00000060237
RB1 GeneProduct ensembl:ENSG00000139687
NME8 GeneProduct ensembl:ENSG00000086288
IFT88 GeneProduct ensembl:ENSG00000032742
IFT80 GeneProduct ensembl:ENSG00000068885
IFT172 GeneProduct ensembl:ENSG00000138002
IFT22 GeneProduct ensembl:ENSG00000128581
TTC30B GeneProduct ensembl:ENSG00000196659
TTC30A GeneProduct ensembl:ENSG00000197557
TTC26 GeneProduct ensembl:ENSG00000105948
HSPB11 GeneProduct ensembl:ENSG00000081870
CLUAP1 GeneProduct ensembl:ENSG00000103351
TRAF3IP1 GeneProduct ensembl:ENSG00000204104
EXOC6B GeneProduct ensembl:ENSG00000144036
EXOC6 GeneProduct ensembl:ENSG00000138190
EXOC7 GeneProduct ensembl:ENSG00000182473
EXOC5 GeneProduct ensembl:ENSG00000070367
EXOC2 GeneProduct ensembl:ENSG00000112685
EXOC3 GeneProduct ensembl:ENSG00000180104
EXOC1 GeneProduct ensembl:ENSG00000090989
EXOC4 GeneProduct ensembl:ENSG00000131558
EXOC2 GeneProduct ensembl:ENSG00000112685
EXOC3 GeneProduct ensembl:ENSG00000180104
EXOC1 GeneProduct ensembl:ENSG00000090989
EXOC6B GeneProduct ensembl:ENSG00000144036
EXOC6 GeneProduct ensembl:ENSG00000138190
EXOC7 GeneProduct ensembl:ENSG00000182473
EXOC5 GeneProduct ensembl:ENSG00000070367
EXOC4 GeneProduct ensembl:ENSG00000131558
RALB GeneProduct ensembl:ENSG00000144118
BBS1 GeneProduct ensembl:ENSG00000174483
BBS2 GeneProduct ensembl:ENSG00000125124
BBS5 GeneProduct ensembl:ENSG00000163093
BBS4 GeneProduct ensembl:ENSG00000140463
BBS7 GeneProduct ensembl:ENSG00000138686
TCTEX1D2 GeneProduct ensembl:ENSG00000213123
PAFAH1B1 GeneProduct ensembl:ENSG00000007168
DYNLRB2 GeneProduct ensembl:ENSG00000168589
DYNLRB1 GeneProduct ensembl:ENSG00000125971
MAPRE2 GeneProduct ensembl:ENSG00000166974
WDR60 GeneProduct ensembl:ENSG00000126870
DYNLT1 GeneProduct ensembl:ENSG00000146425
WDR34 GeneProduct ensembl:ENSG00000119333
DYNLT3 GeneProduct ensembl:ENSG00000165169
TIPRL GeneProduct ensembl:ENSG00000143155
TCTEX1D2 GeneProduct ensembl:ENSG00000213123
DYNLT3 GeneProduct ensembl:ENSG00000165169
DYNC1H1 GeneProduct ensembl:ENSG00000197102
DYNLT1 GeneProduct ensembl:ENSG00000146425
PAFAH1B1 GeneProduct ensembl:ENSG00000007168
DYNC1I2 GeneProduct ensembl:ENSG00000077380
DYNC1LI1 GeneProduct ensembl:ENSG00000144635
WHRN GeneProduct ensembl:ENSG00000095397
VIM GeneProduct ensembl:ENSG00000026025
ZYG11B GeneProduct ensembl:ENSG00000162378
GLB1 GeneProduct ensembl:ENSG00000170266
NEFL GeneProduct ensembl:ENSG00000277586
NEFM GeneProduct ensembl:ENSG00000104722
XPNPEP3 GeneProduct ensembl:ENSG00000196236
GID4 GeneProduct ensembl:ENSG00000141034
ARMC8 GeneProduct ensembl:ENSG00000114098
RANBP9 GeneProduct ensembl:ENSG00000010017
RMND5B GeneProduct ensembl:ENSG00000145916
RANBP10 GeneProduct ensembl:ENSG00000141084
MAEA GeneProduct ensembl:ENSG00000090316
MKLN1 GeneProduct ensembl:ENSG00000128585
GID8 GeneProduct ensembl:ENSG00000101193
LCN2 GeneProduct ensembl:ENSG00000148346
WDR26 GeneProduct ensembl:ENSG00000162923
YPEL5 GeneProduct ensembl:ENSG00000119801
EFHC2 GeneProduct ensembl:ENSG00000183690
PGRMC2 GeneProduct ensembl:ENSG00000164040
UBE2H GeneProduct ensembl:ENSG00000186591
RMND5A GeneProduct ensembl:ENSG00000153561
HTRA2 GeneProduct ensembl:ENSG00000115317
DDX5 GeneProduct ensembl:ENSG00000108654
ZMYND19 GeneProduct ensembl:ENSG00000165724
RAB8A GeneProduct ensembl:ENSG00000167461
ANKS6 GeneProduct ensembl:ENSG00000165138
ANKS3 GeneProduct ensembl:ENSG00000168096
NEK7 GeneProduct ensembl:ENSG00000151414
NEK8 GeneProduct ensembl:ENSG00000160602
MYL6 GeneProduct ensembl:ENSG00000092841
TBC1D4 GeneProduct ensembl:ENSG00000136111
CEP290 GeneProduct ensembl:ENSG00000198707
IQGAP2 GeneProduct ensembl:ENSG00000145703
CALM1 GeneProduct ensembl:ENSG00000198668
LRPPRC GeneProduct ensembl:ENSG00000138095
IQCB1 GeneProduct ensembl:ENSG00000173226
IQGAP3 GeneProduct ensembl:ENSG00000183856
IQGAP1 GeneProduct ensembl:ENSG00000140575
COX6C GeneProduct ensembl:ENSG00000164919
STOM GeneProduct ensembl:ENSG00000148175
MYL6B GeneProduct ensembl:ENSG00000196465
RAC1 GeneProduct ensembl:ENSG00000136238
EIF5B GeneProduct ensembl:ENSG00000158417
EXOSC2 GeneProduct ensembl:ENSG00000130713
EXOSC4 GeneProduct ensembl:ENSG00000178896
EXOSC7 GeneProduct ensembl:ENSG00000075914
TCEB2 GeneProduct ensembl:ENSG00000138663
PSMD13 GeneProduct ensembl:ENSG00000185627
EHD3 GeneProduct ensembl:ENSG00000013016
AAR2 GeneProduct ensembl:ENSG00000131043
DOCK5 GeneProduct ensembl:ENSG00000147459
FUZ GeneProduct ensembl:ENSG00000010361
PSMD8 GeneProduct ensembl:ENSG00000099341
APMAP GeneProduct ensembl:ENSG00000101474
SMC4 GeneProduct ensembl:ENSG00000113810
AGPAT2 GeneProduct ensembl:ENSG00000169692
PSMD7 GeneProduct ensembl:ENSG00000103035
AFG3L2 GeneProduct ensembl:ENSG00000141385
RNGTT GeneProduct ensembl:ENSG00000111880
PSMC6 GeneProduct ensembl:ENSG00000100519
PSMD12 GeneProduct ensembl:ENSG00000197170
VAPB GeneProduct ensembl:ENSG00000124164
INTU GeneProduct ensembl:ENSG00000164066
PSMC4 GeneProduct ensembl:ENSG00000013275

References

  1. Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen T-MT, Texier Y, et al. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nat Commun. 2016 May 13;7:11491. PubMed Europe PMC Scholia