Insulin signaling (WP439)

Insulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose from the blood. Other branches of the signal cascade lead to cell growth and differentation.
last edited

Authors

Nsalomonis, MaintBot, BruceConklin, Khanspers, Christine Chichester, Mkutmon, Tristanvanderlinden, and Eweitz

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: insulin signaling pathway

Participants

Label Type Compact Identifier
Stxbp2 GeneProduct ensembl:ENSRNOG00000000994
Pik3cd GeneProduct ensembl:ENSRNOG00000016846
Pik3c3 GeneProduct ensembl:ENSRNOG00000017840
Cyth3 GeneProduct ensembl:ENSRNOG00000001065
Ptprf GeneProduct ensembl:ENSRNOG00000019977
Rac1 GeneProduct ensembl:ENSRNOG00000001068
Gsk3b GeneProduct ensembl:ENSRNOG00000002833
Reg1a GeneProduct ensembl:ENSRNOG00000006486
Mink1 GeneProduct ensembl:ENSRNOG00000033508
Grb2 GeneProduct ensembl:ENSRNOG00000003990
Shc3 GeneProduct ensembl:ENSRNOG00000014366
Irs1 GeneProduct ensembl:ENSRNOG00000014597
Slc2a1 GeneProduct ensembl:ENSRNOG00000007284
Rps6ka4 GeneProduct ensembl:ENSRNOG00000021117
Ikbkb GeneProduct ensembl:ENSRNOG00000019073
Map4k4 GeneProduct ensembl:ENSRNOG00000014013
Socs3 GeneProduct ensembl:ENSRNOG00000002946
Prkch GeneProduct ensembl:ENSRNOG00000004873
Kif5b GeneProduct ensembl:ENSRNOG00000017466
Irs1 GeneProduct ensembl:ENSRNOG00000014597
Ehd2 GeneProduct ensembl:ENSRNOG00000011346
Arf6 GeneProduct ensembl:ENSRNOG00000004791
Gyg1 GeneProduct ensembl:ENSRNOG00000011146
Akt2 GeneProduct ensembl:ENSRNOG00000018677
Srf GeneProduct ensembl:ENSRNOG00000018232
Map3k2 GeneProduct ensembl:ENSRNOG00000014089
Rab4a GeneProduct ensembl:ENSRNOG00000017467
Prkcd GeneProduct ensembl:ENSRNOG00000016346
Akt1 GeneProduct ensembl:ENSRNOG00000028629
Cap1 GeneProduct ensembl:ENSRNOG00000013492
Rheb GeneProduct ensembl:ENSRNOG00000050578
Pfkm GeneProduct ensembl:ENSRNOG00000057988
Stxbp1 GeneProduct ensembl:ENSRNOG00000015420
PIK3R3 GeneProduct None
Mapk12 GeneProduct ensembl:ENSRNOG00000031233
Pik3r1 GeneProduct ensembl:ENSRNOG00000018903
Map3k5 GeneProduct ensembl:ENSRNOG00000031700
Irs2 GeneProduct ensembl:ENSRNOG00000023509
Pik3c2g GeneProduct ensembl:ENSRNOG00000034228
Pik3r2 GeneProduct ensembl:ENSRNOG00000019228
Mapk10 GeneProduct ensembl:ENSRNOG00000002079
Map3k3 GeneProduct ensembl:ENSRNOG00000061424
Map4k1 GeneProduct ensembl:ENSRNOG00000020505
Mapk3 GeneProduct ensembl:ENSRNOG00000053583
Rps6ka3 GeneProduct ensembl:ENSRNOG00000006632
Pten GeneProduct ensembl:ENSRNOG00000020723
Elk1 GeneProduct ensembl:ENSRNOG00000010171
Shc1 GeneProduct ensembl:ENSRNOG00000020657
Crk GeneProduct ensembl:ENSRNOG00000025792
Trib3 GeneProduct ensembl:ENSRNOG00000007319
Stxbp4 GeneProduct ensembl:ENSRNOG00000032768
Rps6ka6 GeneProduct ensembl:ENSRNOG00000002592
Insr GeneProduct ensembl:ENSRNOG00000029986
Xbp1 GeneProduct ensembl:ENSRNOG00000010298
Foxo1 GeneProduct ensembl:ENSRNOG00000013397
Eif4ebp1 GeneProduct ensembl:ENSRNOG00000012582
Tbc1d4 GeneProduct ensembl:ENSRNOG00000009431
Prkcb GeneProduct ensembl:ENSRNOG00000012061
Map2k7 GeneProduct ensembl:ENSRNOG00000001047
Rps6kb2 GeneProduct ensembl:ENSRNOG00000021689
Sos1 GeneProduct ensembl:ENSRNOG00000007106
Rac2 GeneProduct ensembl:ENSRNOG00000007350
Fos GeneProduct ensembl:ENSRNOG00000008015
Pik3cg GeneProduct ensembl:ENSRNOG00000009385
Rrad GeneProduct ensembl:ENSRNOG00000011901
AABR07037536.1 GeneProduct ensembl:ENSRNOG00000056810
IRS4 GeneProduct None
Sgk3 GeneProduct ensembl:ENSRNOG00000049052
Sh2b2 GeneProduct ensembl:ENSRNOG00000001425
Mapk13 GeneProduct ensembl:ENSRNOG00000000515
Gys1 GeneProduct ensembl:ENSRNOG00000020812
Tsc2 GeneProduct ensembl:ENSRNOG00000011375
LOC100910021 GeneProduct ensembl:ENSRNOG00000023622
Ehd1 GeneProduct ensembl:ENSRNOG00000043503
LOC100912399 GeneProduct ensembl:ENSRNOG00000013177
Map4k3 GeneProduct ensembl:ENSRNOG00000007172
Enpp1 GeneProduct ensembl:ENSRNOG00000013994
Map2k6 GeneProduct ensembl:ENSRNOG00000004437
Arhgap33 GeneProduct ensembl:ENSRNOG00000024677
Slc2a4 GeneProduct ensembl:ENSRNOG00000017226
Map3k8 GeneProduct ensembl:ENSRNOG00000016378
Pfkl GeneProduct ensembl:ENSRNOG00000001214
Tsc1 GeneProduct ensembl:ENSRNOG00000011470
Map3k12 GeneProduct ensembl:ENSRNOG00000015134
Rps6ka5 GeneProduct ensembl:ENSRNOG00000004362
Stx4 GeneProduct ensembl:ENSRNOG00000019302
Igf1r GeneProduct ensembl:ENSRNOG00000014187
Prkcz GeneProduct ensembl:ENSRNOG00000015480
Snap25 GeneProduct ensembl:ENSRNOG00000006037
Map2k4 GeneProduct ensembl:ENSRNOG00000003834
Grb14 GeneProduct ensembl:ENSRNOG00000052498
Prkcq GeneProduct ensembl:ENSRNOG00000019057
Rps6ka1 GeneProduct ensembl:ENSRNOG00000042411
LOC100912585 GeneProduct ensembl:ENSRNOG00000002412
Rps6ka2 GeneProduct ensembl:ENSRNOG00000013194
Mapk14 GeneProduct ensembl:ENSRNOG00000000513
Rps6kb1 GeneProduct ensembl:ENSRNOG00000003919
Rhoq GeneProduct ensembl:ENSRNOG00000015415
Map3k11 GeneProduct ensembl:ENSRNOG00000020773
Prkaa2 GeneProduct ensembl:ENSRNOG00000007706
SNAP23 GeneProduct ensembl:ENSRNOG00000050552
Ptpn1 GeneProduct ensembl:ENSRNOG00000010574
Raptor GeneProduct ensembl:ENSRNOG00000003821
Mapk8 GeneProduct ensembl:ENSRNOG00000020155
Inppl1 GeneProduct ensembl:ENSRNOG00000019730
Cblb GeneProduct ensembl:ENSRNOG00000001982
LOC100910771 GeneProduct ensembl:ENSRNOG00000005724
Stxbp3 GeneProduct ensembl:ENSRNOG00000020392
Inpp4a GeneProduct ensembl:ENSRNOG00000017660
Sgk1 GeneProduct ensembl:ENSRNOG00000011815
Cbl GeneProduct ensembl:ENSRNOG00000008444
Pik3r4 GeneProduct ensembl:ENSRNOG00000013669
Mapk11 GeneProduct ensembl:ENSRNOG00000006984
Mapk9 GeneProduct ensembl:ENSRNOG00000002823
Ptpn11 GeneProduct ensembl:ENSRNOG00000030124
Gys2 GeneProduct ensembl:ENSRNOG00000059753
Jun GeneProduct ensembl:ENSRNOG00000026293
Socs1 GeneProduct ensembl:ENSRNOG00000002568
Mapk6 GeneProduct ensembl:ENSRNOG00000009381
Eif4e GeneProduct ensembl:ENSRNOG00000052343
Shc2 GeneProduct ensembl:ENSRNOG00000008030
Flot2 GeneProduct ensembl:ENSRNOG00000009681
Cblc GeneProduct ensembl:ENSRNOG00000018953
Myo1c GeneProduct ensembl:ENSRNOG00000004072
Gab1 GeneProduct ensembl:ENSRNOG00000017879
Rhoj GeneProduct ensembl:ENSRNOG00000021919
Gsk3a GeneProduct ensembl:ENSRNOG00000020417
Prkci GeneProduct ensembl:ENSRNOG00000009652
Prkaa1 GeneProduct ensembl:ENSRNOG00000012799
Sorbs1 GeneProduct ensembl:ENSRNOG00000015658
Sos2 GeneProduct ensembl:ENSRNOG00000004826
Map3k13 GeneProduct ensembl:ENSRNOG00000025423
Ppp1r3a GeneProduct ensembl:ENSRNOG00000059350
Raf1 GeneProduct ensembl:ENSRNOG00000010153
Arf1 GeneProduct ensembl:ENSRNOG00000060229
Mtor GeneProduct ensembl:ENSRNOG00000009615
Prkca GeneProduct ensembl:ENSRNOG00000003491
Lipe GeneProduct ensembl:ENSRNOG00000020546
Map2k3 GeneProduct ensembl:ENSRNOG00000049132
Mapk4 GeneProduct ensembl:ENSRNOG00000015401
Map4k2 GeneProduct ensembl:ENSRNOG00000021061
Pdpk1 GeneProduct ensembl:ENSRNOG00000006136
Hras GeneProduct ensembl:ENSRNOG00000016611
Rapgef1 GeneProduct ensembl:ENSRNOG00000014316
Foxo3 GeneProduct ensembl:ENSRNOG00000000299
Map2k5 GeneProduct ensembl:ENSRNOG00000007926
Grb10 GeneProduct ensembl:ENSRNOG00000004290
Egr1 GeneProduct ensembl:ENSRNOG00000019422
Map3k10 GeneProduct ensembl:ENSRNOG00000023521
Vamp2 GeneProduct ensembl:ENSRNOG00000006989
Pik3c2a GeneProduct ensembl:ENSRNOG00000020479
Mapk1 GeneProduct ensembl:ENSRNOG00000001849
Flot1 GeneProduct ensembl:ENSRNOG00000000826
AABR07037536.1 GeneProduct ensembl:ENSRNOG00000056810
Map2k1 GeneProduct ensembl:ENSRNOG00000010176
Map3k6 GeneProduct ensembl:ENSRNOG00000008936
Sgk2 GeneProduct ensembl:ENSRNOG00000033573
Map3k4 GeneProduct ensembl:ENSRNOG00000017419
Map3k9 GeneProduct ensembl:ENSRNOG00000007271
Kif3a GeneProduct ensembl:ENSRNOG00000007515
Map4k5 GeneProduct ensembl:ENSRNOG00000004923
Map2k2 GeneProduct ensembl:ENSRNOG00000020005
Mapk8 GeneProduct ensembl:ENSRNOG00000020155
Map3k14 GeneProduct ensembl:ENSRNOG00000003278

References

  1. Quon MJ, Campfield LA. A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation. J Theor Biol. 1991 May 7;150(1):93–107. PubMed Europe PMC Scholia
  2. Bevan P. Insulin signalling. J Cell Sci. 2001 Apr;114(Pt 8):1429–30. PubMed Europe PMC Scholia
  3. Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001 Dec 13;414(6865):799–806. PubMed Europe PMC Scholia
  4. Saxton RA, Sabatini DM. mTOR Signaling in Growth, Metabolism, and Disease. Cell. 2017 Mar 9;168(6):960–76. PubMed Europe PMC Scholia