Nonalcoholic fatty liver disease (WP4396)

Nonalcoholic fatty liver disease (NAFLD) is a condition in which too much fat is stored in the liver. Nonalcoholic steatohepatitis (NASH) is a type of NAFLD marked by liver inflammation, which may progress to scarring and irreversible damage similar to that caused by heavy alcohol use. Components of glucose matabolism, insulin signaling, inflammation, oxidative stress, ER sgtress and apoptosis are all involved and interconnected in the progression of this disease.
last edited


AlexanderPico and Egonw

Cited In


Homo sapiens




Cell Type Ontology: hepatocyte

Disease Ontology: non-alcoholic fatty liver disease

Pathway Ontology: disease pathway liver disease pathway


Label Type Compact Identifier
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RELA GeneProduct ncbigene:5970
PIK3CA GeneProduct ncbigene:5290
PIK3CD GeneProduct ncbigene:5293
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AKT1 GeneProduct ncbigene:207
AKT2 GeneProduct ncbigene:208
AKT3 GeneProduct ncbigene:10000
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MLX GeneProduct ncbigene:6945
MLXIP GeneProduct ncbigene:22877
MLXIPL GeneProduct ncbigene:51085
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CDC42 GeneProduct ncbigene:998
RAC1 GeneProduct ncbigene:5879
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CXCL8 GeneProduct ncbigene:3576
TGFB1 GeneProduct ncbigene:7040
CASP3 GeneProduct ncbigene:836
CASP7 GeneProduct ncbigene:840
NDUFV1 GeneProduct ncbigene:4723
NDUFV2 GeneProduct ncbigene:4729
NDUFV3 GeneProduct ncbigene:4731
NDUFA1 GeneProduct ncbigene:4694
NDUFA2 GeneProduct ncbigene:4695
NDUFA3 GeneProduct ncbigene:4696
NDUFA4 GeneProduct ncbigene:4697
NDUFA4L2 GeneProduct ncbigene:56901
NDUFA5 GeneProduct ncbigene:4698
NDUFA6 GeneProduct ncbigene:4700
NDUFA7 GeneProduct ncbigene:4701
NDUFA8 GeneProduct ncbigene:4702
NDUFA9 GeneProduct ncbigene:4704
NDUFA10 GeneProduct ncbigene:4705
NDUFAB1 GeneProduct ncbigene:4706
NDUFA11 GeneProduct ncbigene:126328
NDUFA12 GeneProduct ncbigene:55967
NDUFA13 GeneProduct ncbigene:51079
NDUFB1 GeneProduct ncbigene:4707
NDUFB2 GeneProduct ncbigene:4708
NDUFB3 GeneProduct ncbigene:4709
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NDUFS1 GeneProduct ncbigene:4719
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NDUFS8 GeneProduct ncbigene:4728
NDUFC1 GeneProduct ncbigene:4717
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NDUFC2-KCTD14 GeneProduct ncbigene:100532726
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SDHB GeneProduct ncbigene:6390
SDHC GeneProduct ncbigene:6391
SDHD GeneProduct ncbigene:6392
UQCRFS1 GeneProduct ncbigene:7386
CYTB GeneProduct ncbigene:4519
CYC1 GeneProduct ncbigene:1537
UQCRC1 GeneProduct ncbigene:7384
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UQCRH GeneProduct ncbigene:7388
UQCRHL GeneProduct ncbigene:440567
UQCRB GeneProduct ncbigene:7381
UQCRQ GeneProduct ncbigene:27089
UQCR10 GeneProduct ncbigene:29796
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COX1 GeneProduct ncbigene:4512
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COX7A1 GeneProduct ncbigene:1346
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COX7A2L GeneProduct ncbigene:9167
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COX7C GeneProduct ncbigene:1350
COX8C GeneProduct ncbigene:341947
COX8A GeneProduct ncbigene:1351
TRAF2 GeneProduct ncbigene:7186
oxysterols Metabolite chebi:53030
Oxidative Phosphorylation Pathway wikipathways:WP623
ROS Metabolite chebi:26523
SREBF1 GeneProduct ncbigene:6720
IRS1 GeneProduct ncbigene:3667
CYCS GeneProduct ncbigene:54205
TNF GeneProduct ncbigene:7124
FXR GeneProduct ncbigene:9971
EIF2AK3 GeneProduct ncbigene:9451
BAK1 GeneProduct ncbigene:578
XBP1 GeneProduct ncbigene:7494
ATF4 GeneProduct ncbigene:468
CEBPA GeneProduct ncbigene:1050
NR1H3 GeneProduct ncbigene:10062
PKLR GeneProduct ncbigene:5313
INS GeneProduct ncbigene:3630
mir21 Rna ncbigene:406991
BAX GeneProduct ncbigene:581
DDIT3 GeneProduct ncbigene:1649
IL6R GeneProduct ncbigene:3570
Fatty Acid Biosynthesis Pathway wikipathways:WP357
Lipogenic Enzymes GeneProduct None
FASLG GeneProduct ncbigene:356
Insulin Signaling Pathway wikipathways:WP481
Apoptosis Pathway wikipathways:WP254
LEPR GeneProduct ncbigene:3953
LEP GeneProduct ncbigene:3952
CxI GeneProduct None
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CASP8 GeneProduct ncbigene:841
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EIF2S1 GeneProduct ncbigene:1965
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selonsertib Metabolite wikidata:Q27088777
INSR GeneProduct ncbigene:3643
PPAR Signaling Pathway wikipathways:WP3942
D-glucose Metabolite chebi:42758
BID GeneProduct ncbigene:637
IKBKB GeneProduct ncbigene:3551
fatty acids Metabolite chebi:35366
FAS GeneProduct ncbigene:355
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ADIPOQ GeneProduct ncbigene:9370
IL6 GeneProduct ncbigene:3569
IL6 GeneProduct ncbigene:3569
CxII GeneProduct None
CxIII GeneProduct None
CxIV GeneProduct None
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TNF GeneProduct ncbigene:7124
TNF GeneProduct ncbigene:7124
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TCA Cycle Pathway wikipathways:WP78
CCL2 GeneProduct ncbigene:6347
VCAM1 GeneProduct ncbigene:7412
SMAD7 GeneProduct ncbigene:4092


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