Matrix metalloproteinases (WP441)

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily. Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense. Source: [[wikipedia:Matrix_metalloproteinase|Wikipedia]]
last edited

Authors

Kdahlquist, MaintBot, M.Braymer, Khanspers, Thomas, Ddigles, and Eweitz

Cited In

Organism

Mus musculus

Communities

Annotations

Pathway Ontology: cell-extracellular matrix signaling pathway

Participants

Label Type Compact Identifier
Mmp23 GeneProduct ncbigene:26561
Mmp27 GeneProduct ncbigene:234911
Mmp2 GeneProduct ncbigene:17390
Mmp11 GeneProduct ncbigene:17385
Mmp15 GeneProduct ncbigene:17388
Mmp25 GeneProduct ncbigene:240047
Mmp9 GeneProduct ncbigene:17395
Mmp3 GeneProduct ncbigene:17392
Mmp28 GeneProduct ncbigene:118453
Timp2 GeneProduct ncbigene:21858
Mmp7 GeneProduct ncbigene:17393
Mmp10 GeneProduct ncbigene:17384
Mmp17 GeneProduct ncbigene:23948
Mmp19 GeneProduct ncbigene:58223
Bsg GeneProduct ncbigene:12215
Mmp12 GeneProduct ncbigene:17381
Mmp16 GeneProduct ncbigene:17389
Tcf20 GeneProduct ncbigene:21411
Mmp14 GeneProduct ncbigene:17387
Mmp21 GeneProduct ncbigene:214766
Mmp20 GeneProduct ncbigene:30800
Timp1 GeneProduct ncbigene:21857
Mmp8 GeneProduct ncbigene:17394
Mmp13 GeneProduct ncbigene:17386
Timp3 GeneProduct ncbigene:21859
Mmp24 GeneProduct ncbigene:17391
Tnf GeneProduct ncbigene:21926
Mmp1a GeneProduct ncbigene:83995
MMP23A GeneProduct None
MMP26 GeneProduct None
Timp4 GeneProduct ncbigene:110595

References

  1. Vu TH, Werb Z. Matrix metalloproteinases: effectors of development and normal physiology. Genes Dev. 2000 Sep 1;14(17):2123–33. PubMed Europe PMC Scholia