Selective expression of chemokine receptors during T-cell polarization (WP4494)

Selective expression of chemokine receptors during T-cell polarization. Pathway based on Biocarta pathway (M4047). https://cgap.nci.nih.gov/Pathways/BioCarta/h_nktPathway The polarization of T cells into Th1 and Th2 cells is associated with their expression of subsets of chemokine receptors. While not being exposed to antigens, naïve T cells express CXCR4 and CCR7 receptors. TGF-beta van induce semi-naive T cells, that express a subset of CCR4 and CCR7 receptors. Th1 express CXCR3, CCR1, CCR2 and CCR5 receptors, while Th2 express CCR2, CCR3 and CCR5. However these subsets are not absolute as there is overlap between the expression of receptor subsets and thus between Th1 and Th2 cells.
last edited

Authors

Laurent, Fehrhart, and Mkutmon

Cited In

Organism

Homo sapiens

Communities

Annotations

Cell Type Ontology: T cell

Pathway Ontology: chemokine mediated signaling pathway

Participants

Label Type Compact Identifier
CCL3 GeneProduct ncbigene:6348
CCR7 GeneProduct ncbigene:1236
CXCR4 GeneProduct ncbigene:7852
IL12A GeneProduct ncbigene:3592
IL12B GeneProduct ncbigene:3593
IL4 GeneProduct ncbigene:3565
IL5 GeneProduct ncbigene:3567
TGFB1 GeneProduct ncbigene:7040
TGFB2 GeneProduct ncbigene:7042
TGFB3 GeneProduct ncbigene:7043
CD4 GeneProduct ncbigene:920
IL2 GeneProduct ncbigene:3558
CSF2 GeneProduct ncbigene:1437
IFNG GeneProduct ncbigene:3458
CCL4 GeneProduct ncbigene:6351
CD28 GeneProduct ncbigene:940
CD40LG GeneProduct ncbigene:959
IL12RB1 GeneProduct ncbigene:3594
IL12RB2 GeneProduct ncbigene:3595
IL18R1 GeneProduct ncbigene:8809
IL12RB1 GeneProduct ncbigene:3594
IL12RB2 GeneProduct ncbigene:3595
IL4R GeneProduct ncbigene:3566
CD28 GeneProduct ncbigene:940
CD40LG GeneProduct ncbigene:959
IFNGR1 GeneProduct ncbigene:3459
IFNGR2 GeneProduct ncbigene:3460
IL4 GeneProduct ncbigene:3565
IL2 GeneProduct ncbigene:3558
CCR3 GeneProduct ncbigene:1232
CCR4 GeneProduct ncbigene:1233
CXCR3 GeneProduct ncbigene:2833
CCR2 GeneProduct ncbigene:729230
CCR1 GeneProduct ncbigene:1230
CCR5 GeneProduct ncbigene:1234
CCR3 GeneProduct ncbigene:1232
CCR4 GeneProduct ncbigene:1233
CCR2 GeneProduct ncbigene:729230
IL12B GeneProduct ncbigene:3593
IL12A GeneProduct ncbigene:3592
IL12B GeneProduct ncbigene:3593
IL12A GeneProduct ncbigene:3592
IL12B GeneProduct ncbigene:3593
IL12A GeneProduct ncbigene:3592
IFNG GeneProduct ncbigene:3458

References

  1. de Jong EC, Smits HH, Kapsenberg ML. Dendritic cell-mediated T cell polarization. Springer Semin Immunopathol. 2005 Jan;26(3):289–307. PubMed Europe PMC Scholia