Hippo signaling regulation pathways (WP4540)

Hippo signaling and the activation of YAP1/TAZ transcription is regulated by many other pathways (green labels) and factors. For example, the activation of SMAD and Beta catenin/TCF/LEF via TGF-beta signaling and WNT signaling pathways, respectively, enhanced the transcription of YAP1/TAZ target genes. This enhanced activity induces more aggressive phenotypes of malignant mesothelioma cells such as cell proliferation, invasion, and epithelial–mesenchymal transition (EMT).
last edited


AlexanderPico, Eweitz, and Fehrhart

Cited In


Homo sapiens


Diseases Rare Diseases


Disease Ontology: malignant mesothelioma

Pathway Ontology: Hippo signaling pathway signaling pathway disease pathway


Label Type Compact Identifier
PRKAA1 GeneProduct ncbigene:5562
PRKAA2 GeneProduct ncbigene:5563
PRKAB1 GeneProduct ncbigene:5564
PRKAB2 GeneProduct ncbigene:5565
PRKAG1 GeneProduct ncbigene:5571
PRKAG2 GeneProduct ncbigene:51422
PRKAG3 GeneProduct ncbigene:53632
CDH1 GeneProduct ncbigene:999
CDH10 GeneProduct ncbigene:1008
CDH11 GeneProduct ncbigene:1009
CDH12 GeneProduct ncbigene:1010
CDH13 GeneProduct ncbigene:1012
CDH15 GeneProduct ncbigene:1013
CDH16 GeneProduct ncbigene:1014
CDH17 GeneProduct ncbigene:1015
CDH18 GeneProduct ncbigene:1016
CDH19 GeneProduct ncbigene:28513
CDH2 GeneProduct ncbigene:1000
CDH20 GeneProduct ncbigene:28316
CDH22 GeneProduct ncbigene:64405
CDH24 GeneProduct ncbigene:64403
CDH3 GeneProduct ncbigene:1001
CDH4 GeneProduct ncbigene:1002
CDH5 GeneProduct ncbigene:1003
CDH6 GeneProduct ncbigene:1004
CDH7 GeneProduct ncbigene:1005
CDH8 GeneProduct ncbigene:1006
CDH9 GeneProduct ncbigene:1007
GNA11 GeneProduct ncbigene:2767
GNAI2 GeneProduct ncbigene:2771
GNAI3 GeneProduct ncbigene:2773
GNAL GeneProduct ncbigene:2774
GNAQ GeneProduct ncbigene:2776
GNAS GeneProduct ncbigene:2778
PRKACA GeneProduct ncbigene:5566
PRKACB GeneProduct ncbigene:5567
PRKACG GeneProduct ncbigene:5568
PRKAR1A GeneProduct ncbigene:5573
PRKAR1B GeneProduct ncbigene:5575
PRKAR2A GeneProduct ncbigene:5576
PRKAR2B GeneProduct ncbigene:5577
PRKCA GeneProduct ncbigene:5578
PRKCB GeneProduct ncbigene:5579
PRKCD GeneProduct ncbigene:5580
PRKCE GeneProduct ncbigene:5581
PRKCG GeneProduct ncbigene:5582
PRKCH GeneProduct ncbigene:5583
PRKCI GeneProduct ncbigene:5584
PRKCQ GeneProduct ncbigene:5588
PRKCZ GeneProduct ncbigene:5590
PRKD3 GeneProduct ncbigene:23683
PLCB1 GeneProduct ncbigene:23236
PLCB2 GeneProduct ncbigene:5330
PLCB3 GeneProduct ncbigene:5331
PLCB4 GeneProduct ncbigene:5332
SMAD3 GeneProduct ncbigene:4088
Mevalonate Pathway Pathway wikipathways:WP3963
Energy Stress Pathway None
G Protein Signaling Pathway wikipathways:WP35
CDC42 GeneProduct ncbigene:998
SMAD2 GeneProduct ncbigene:4087
MTOR GeneProduct ncbigene:2475
LATS2 GeneProduct ncbigene:26524
STK3 GeneProduct ncbigene:6788
LATS1 GeneProduct ncbigene:9113
YY1AP1 GeneProduct ncbigene:55249
NF2 GeneProduct ncbigene:4771
TAZ GeneProduct ncbigene:6901
MST1 GeneProduct ncbigene:4485
TEAD1 GeneProduct ensembl:ENSG00000187079
YY1AP1 GeneProduct ncbigene:55249
TAZ GeneProduct ncbigene:6901
TEAD2 GeneProduct ensembl:ENSG00000074219
TEAD3 GeneProduct ensembl:ENSG00000007866
TEAD4 GeneProduct ensembl:ENSG00000197905
TGF-Beta Signaling Pathway wikipathways:WP560
FGFR2 GeneProduct ensembl:ENSG00000066468
KDR GeneProduct ensembl:ENSG00000128052
INSR GeneProduct ensembl:ENSG00000171105
FGFR3 GeneProduct ensembl:ENSG00000068078
IGF1R GeneProduct ensembl:ENSG00000140443
KIT GeneProduct ensembl:ENSG00000157404
FGFR1 GeneProduct ensembl:ENSG00000077782
EPHA2 GeneProduct ensembl:ENSG00000142627
EGFR GeneProduct ensembl:ENSG00000146648
CSF1R GeneProduct ensembl:ENSG00000182578
FGFR4 GeneProduct ensembl:ENSG00000160867
FLT1 GeneProduct ensembl:ENSG00000102755
FLT4 GeneProduct ensembl:ENSG00000037280
NGFR GeneProduct ensembl:ENSG00000064300
MET GeneProduct ensembl:ENSG00000105976
PDGFRA GeneProduct ensembl:ENSG00000134853
PDGFRB GeneProduct ensembl:ENSG00000113721
TEK GeneProduct ensembl:ENSG00000120156
FLT3 GeneProduct ensembl:ENSG00000122025
NTRK1 GeneProduct ensembl:ENSG00000198400
NTRK2 GeneProduct ensembl:ENSG00000148053
PI3K/AKT Signaling Pathway wikipathways:WP4172
RHOA GeneProduct ncbigene:387
RAC1 GeneProduct ncbigene:5879
WNT Signaling Pathway wikipathways:WP428
LEF1 GeneProduct ensembl:ENSG00000138795
TCF7L1 GeneProduct ensembl:ENSG00000152284
TCF7L2 GeneProduct ensembl:ENSG00000148737
TCF7 GeneProduct ensembl:ENSG00000081059
CTNNB1 GeneProduct ncbigene:1499


  1. Sekido Y. Targeting the Hippo Pathway Is a New Potential Therapeutic Modality for Malignant Mesothelioma. Cancers (Basel). 2018 Mar 22;10(4):90. PubMed Europe PMC Scholia