Hippo-Merlin signaling dysregulation (WP4541)

The Hippo-Merlin(NF2) signaling pathway can become dysregulated at many points as observed in malignant mesothelioma cells. Extracellular signals via cadherin, CD44, integrin or RTKs, as well as various signaling pathway components, can affect NF2 tumor suppression. Direct alteration of merlin and LATS1/2 can also result in underphosphorylated (activated) YAP1(YY1AP1)/TAZ transcriptional coactivators, leading to the induction of pro-oncogene expression.
last edited


Alex Pico , Marvin Martens , and Eric Weitz

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Homo sapiens


CPTAC Diseases Rare Diseases


Pathway Ontology: Hippo signaling pathway altered Hippo signaling pathway signaling pathway disease pathway


Label Type Compact Identifier
CDH1 GeneProduct ncbigene:999
CDH10 GeneProduct ncbigene:1008
CDH11 GeneProduct ncbigene:1009
CDH12 GeneProduct ncbigene:1010
CDH13 GeneProduct ncbigene:1012
CDH15 GeneProduct ncbigene:1013
CDH16 GeneProduct ncbigene:1014
CDH17 GeneProduct ncbigene:1015
CDH18 GeneProduct ncbigene:1016
CDH19 GeneProduct ncbigene:28513
CDH2 GeneProduct ncbigene:1000
CDH20 GeneProduct ncbigene:28316
CDH22 GeneProduct ncbigene:64405
CDH24 GeneProduct ncbigene:64403
CDH3 GeneProduct ncbigene:1001
CDH4 GeneProduct ncbigene:1002
CDH5 GeneProduct ncbigene:1003
CDH6 GeneProduct ncbigene:1004
CDH7 GeneProduct ncbigene:1005
CDH8 GeneProduct ncbigene:1006
CDH9 GeneProduct ncbigene:1007
PRKACA GeneProduct ncbigene:5566
PRKACB GeneProduct ncbigene:5567
PRKACG GeneProduct ncbigene:5568
PRKAR1A GeneProduct ncbigene:5573
PRKAR2A GeneProduct ncbigene:5576
PRKAR2B GeneProduct ncbigene:5577
ITGA1 GeneProduct hgnc.symbol:ITGA1
ITGA2 GeneProduct hgnc.symbol:ITGA2
ITGA3 GeneProduct hgnc.symbol:ITGA3
ITGA4 GeneProduct hgnc.symbol:ITGA4
ITGA5 GeneProduct hgnc.symbol:ITGA5
ITGA6 GeneProduct hgnc.symbol:ITGA6
ITGA7 GeneProduct hgnc.symbol:ITGA7
ITGA8 GeneProduct hgnc.symbol:ITGA8
ITGA9 GeneProduct hgnc.symbol:ITGA9
ITGA10 GeneProduct hgnc.symbol:ITGA10
ITGA11 GeneProduct hgnc.symbol:ITGA11
ITGAD GeneProduct hgnc.symbol:ITGAD
ITGAE GeneProduct hgnc.symbol:ITGAE
ITGAL GeneProduct hgnc.symbol:ITGAL
ITGAM GeneProduct hgnc.symbol:ITGAM
ITGAV GeneProduct hgnc.symbol:ITGAV
ITGA2B GeneProduct hgnc.symbol:ITGA2B
ITGAX GeneProduct hgnc.symbol:ITGAX
ITGB1 GeneProduct hgnc.symbol:ITGB1
ITGB2 GeneProduct hgnc.symbol:ITGB2
ITGB3 GeneProduct hgnc.symbol:ITGB3
ITGB4 GeneProduct hgnc.symbol:ITGB4
ITGB5 GeneProduct hgnc.symbol:ITGB5
ITGB6 GeneProduct hgnc.symbol:ITGB6
ITGB7 GeneProduct hgnc.symbol:ITGB7
ITGB8 GeneProduct hgnc.symbol:ITGB8
PRKAR1B GeneProduct ncbigene:5575
LATS2 GeneProduct ncbigene:26524
STK3 GeneProduct ncbigene:6788
LATS1 GeneProduct ncbigene:9113
NF2 GeneProduct ncbigene:4771
MST1 GeneProduct ncbigene:4485
TEAD1 GeneProduct ensembl:ENSG00000187079
YY1AP1 GeneProduct ncbigene:55249
TAZ GeneProduct ncbigene:6901
TEAD2 GeneProduct ensembl:ENSG00000074219
TEAD3 GeneProduct ensembl:ENSG00000007866
TEAD4 GeneProduct ensembl:ENSG00000197905
FGFR2 GeneProduct ensembl:ENSG00000066468
KDR GeneProduct ensembl:ENSG00000128052
INSR GeneProduct ensembl:ENSG00000171105
FGFR3 GeneProduct ensembl:ENSG00000068078
IGF1R GeneProduct ensembl:ENSG00000140443
KIT GeneProduct ensembl:ENSG00000157404
FGFR1 GeneProduct ensembl:ENSG00000077782
EPHA2 GeneProduct ensembl:ENSG00000142627
EGFR GeneProduct ensembl:ENSG00000146648
CSF1R GeneProduct ensembl:ENSG00000182578
FGFR4 GeneProduct ensembl:ENSG00000160867
FLT1 GeneProduct ensembl:ENSG00000102755
FLT4 GeneProduct ensembl:ENSG00000037280
NGFR GeneProduct ensembl:ENSG00000064300
MET GeneProduct ensembl:ENSG00000105976
PDGFRA GeneProduct ensembl:ENSG00000134853
PDGFRB GeneProduct ensembl:ENSG00000113721
TEK GeneProduct ensembl:ENSG00000120156
FLT3 GeneProduct ensembl:ENSG00000122025
NTRK1 GeneProduct ensembl:ENSG00000198400
NTRK2 GeneProduct ensembl:ENSG00000148053
CXCL10 GeneProduct ncbigene:3627
CD44 GeneProduct ncbigene:960
PAK5 GeneProduct ncbigene:57144
SAV1 GeneProduct ncbigene:60485
PAK3 GeneProduct ncbigene:5063
PAK6 GeneProduct ncbigene:56924
PPP1R14A GeneProduct ncbigene:94274
CTNNB1 GeneProduct ncbigene:1499
CCND1 GeneProduct ncbigene:595
MYC GeneProduct ncbigene:4609
PTK2 GeneProduct ncbigene:5747
PLCB4 GeneProduct ncbigene:5332
AMOT GeneProduct ncbigene:154796
LIN28B GeneProduct ncbigene:389421
PAK4 GeneProduct ncbigene:10298
CTGF GeneProduct ncbigene:1490
VGLL4 GeneProduct ncbigene:9686
NRAS GeneProduct ncbigene:4893
HRAS GeneProduct ncbigene:3265
PPP1R12A GeneProduct ncbigene:4659
FOXM1 GeneProduct ncbigene:2305
PAK1 GeneProduct ncbigene:5058
AJUBA GeneProduct ncbigene:84962
PAK2 GeneProduct ncbigene:5062
KRAS GeneProduct ncbigene:3845
CTNNA1 GeneProduct ncbigene:1495
YY1AP1 GeneProduct ncbigene:55249
TAZ GeneProduct ncbigene:6901
LATS2 GeneProduct ncbigene:26524
LATS1 GeneProduct ncbigene:9113
NF2 GeneProduct ncbigene:4771
MIR98 GeneProduct ncbigene:407054
PPP1CA GeneProduct ncbigene:5499
PPP1CB GeneProduct ncbigene:5500
PPP1CC GeneProduct ncbigene:5501
DCAF1 GeneProduct ncbigene:9730
CUL4A GeneProduct ncbigene:8451
DDB1 GeneProduct ncbigene:1642
RBX1 GeneProduct ncbigene:9978


  1. Sekido Y. Targeting the Hippo Pathway Is a New Potential Therapeutic Modality for Malignant Mesothelioma. Cancers (Basel). 2018 Mar 22;10(4):90. PubMed Europe PMC Scholia