GPCRs, class A rhodopsin-like (WP455)

This pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP455 CPTAC Assay Portal]
last edited

Authors

Nsalomonis, MaintBot, AlexanderPico, BruceConklin, Khanspers, Egonw, Zari, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: G protein mediated signaling pathway

Participants

Label Type Compact Identifier
Opioid Metabolite chebi:60598
Somatostatin Metabolite chebi:64628
GPR32 GeneProduct ncbigene:2854
OR1E2 GeneProduct ncbigene:8388
RRH GeneProduct ncbigene:10692
XCR1 GeneProduct ncbigene:2829
OR3A3 GeneProduct ncbigene:8392
CCR4 GeneProduct ncbigene:1233
OR10H3 GeneProduct ncbigene:26532
DRD2 GeneProduct ncbigene:1813
GPR52 GeneProduct ncbigene:9293
MC1R GeneProduct ncbigene:4157
P2RY10 GeneProduct ncbigene:27334
OPRM1 GeneProduct ncbigene:4988
F2RL1 GeneProduct ncbigene:2150
P2RY4 GeneProduct ncbigene:5030
HTR2B GeneProduct ncbigene:3357
CYSLTR2 GeneProduct ncbigene:57105
MTNR1B GeneProduct ncbigene:4544
HTR1F GeneProduct ncbigene:3355
NPY6R GeneProduct ncbigene:4888
OR7C1 GeneProduct ncbigene:26664
OR5V1 GeneProduct ncbigene:81696
MAS1L GeneProduct ncbigene:116511
CNR1 GeneProduct ncbigene:1268
GPR85 GeneProduct ncbigene:54329
BLR1 GeneProduct ncbigene:643
CCRL1 GeneProduct ncbigene:51554
GPR17 GeneProduct ncbigene:2840
GPR42 GeneProduct ncbigene:2866
P2RY6 GeneProduct ncbigene:5031
GPR8 GeneProduct ncbigene:2832
GALR2 GeneProduct ncbigene:8811
SSTR5 GeneProduct ncbigene:6755
OR7C2 GeneProduct ncbigene:26658
NTSR2 GeneProduct ncbigene:23620
CX3CR1 GeneProduct ncbigene:1524
GPR15 GeneProduct ncbigene:2838
GPR37L1 GeneProduct ncbigene:9283
OR12D3 GeneProduct ncbigene:81797
SSTR4 GeneProduct ncbigene:6754
GPR6 GeneProduct ncbigene:2830
OR8B8 GeneProduct ncbigene:26493
P2RY2 GeneProduct ncbigene:5029
GPR92 GeneProduct ncbigene:57121
GPR39 GeneProduct ncbigene:2863
SSTR2 GeneProduct ncbigene:6752
DRD4 GeneProduct ncbigene:1815
OR7A17 GeneProduct ncbigene:26333
Dopamine Metabolite cas:62-31-7
CCR8 GeneProduct ncbigene:1237
CHRM2 GeneProduct ncbigene:1129
HCRTR1 GeneProduct ncbigene:3061
OPRL1 GeneProduct ncbigene:4987
CXCR3 GeneProduct ncbigene:2833
MTNR1A GeneProduct ncbigene:4543
OPN1MW GeneProduct ncbigene:2652
FPR1 GeneProduct ncbigene:2357
OPRK1 GeneProduct ncbigene:4986
F2RL3 GeneProduct ncbigene:9002
PTGER1 GeneProduct ncbigene:5731
PTGER4 GeneProduct ncbigene:5734
Rgr GeneProduct ncbigene:266747
PTGFR GeneProduct ncbigene:5737
OR2S2 GeneProduct ncbigene:56656
OR2J2 GeneProduct ncbigene:26707
CNR2 GeneProduct ncbigene:1269
ADRA2A GeneProduct ncbigene:150
MLNR GeneProduct ncbigene:2862
HTR4 GeneProduct ncbigene:3360
OR1G1 GeneProduct ncbigene:8390
OR10A4 GeneProduct ncbigene:283297
Bradykinin Metabolite cas:58-82-2
ADORA1 GeneProduct ncbigene:134
NMBR GeneProduct ncbigene:4829
NMUR2 GeneProduct ncbigene:56923
TRHR GeneProduct ncbigene:7201
OPN4 GeneProduct ncbigene:94233
HTR1B GeneProduct ncbigene:3351
GPR19 GeneProduct ncbigene:2842
GPR22 GeneProduct ncbigene:2845
RHO GeneProduct ncbigene:6010
F2R GeneProduct ncbigene:2149
ADORA2A GeneProduct ncbigene:135
FPRL1 GeneProduct ncbigene:2358
OR7A10 GeneProduct ncbigene:390892
SSTR1 GeneProduct ncbigene:6751
CMKLR1 GeneProduct ncbigene:1240
NMUR1 GeneProduct ncbigene:10316
ADRA2C GeneProduct ncbigene:152
ADORA3 GeneProduct ncbigene:140
GPR31 GeneProduct ncbigene:2853
GPR41 GeneProduct ncbigene:2865
GPR24 GeneProduct ncbigene:2847
GPR161 GeneProduct ncbigene:23432
PTAFR GeneProduct ncbigene:5724
OR2B6 GeneProduct ncbigene:26212
GALR1 GeneProduct ncbigene:2587
AGTR1 GeneProduct ncbigene:185
CHRM4 GeneProduct ncbigene:1132
OR2W1 GeneProduct ncbigene:26692
OR2B3 GeneProduct ncbigene:442184
PTGER2 GeneProduct ncbigene:5732
OR2H2 GeneProduct ncbigene:7932
OXTR GeneProduct ncbigene:5021
OR5F1 GeneProduct ncbigene:338674
HCRTR2 GeneProduct ncbigene:3062
GPR37 GeneProduct ncbigene:2861
GPR173 GeneProduct ncbigene:54328
Prostaglandin Metabolite cas:745-65-3
ADRA1B GeneProduct ncbigene:147
GPR34 GeneProduct ncbigene:2857
GPR50 GeneProduct ncbigene:9248
OR1D2 GeneProduct ncbigene:4991
OR1F1 GeneProduct ncbigene:4992
LHCGR GeneProduct ncbigene:3973
OR1D5 GeneProduct ncbigene:8386
P2RY1 GeneProduct ncbigene:5028
HTR5A GeneProduct ncbigene:3361
OR10A5 GeneProduct ncbigene:144124
ADRB1 GeneProduct ncbigene:153
GPR68 GeneProduct ncbigene:8111
HTR6 GeneProduct ncbigene:3362
PTGER3 GeneProduct ncbigene:5733
LTB4R GeneProduct ncbigene:1241
NPY1R GeneProduct ncbigene:4886
OR6A2 GeneProduct ncbigene:8590
OR1C1 GeneProduct ncbigene:26188
GPR65 GeneProduct ncbigene:8477
GPR35 GeneProduct ncbigene:2859
GPR1 GeneProduct ncbigene:2825
P2RY13 GeneProduct ncbigene:53829
OR5U1 GeneProduct ncbigene:442191
CCR3 GeneProduct ncbigene:1232
GPR109B GeneProduct ncbigene:8843
HTR1E GeneProduct ncbigene:3354
GRPR GeneProduct ncbigene:2925
HTR1A GeneProduct ncbigene:3350
OR2F2 GeneProduct ncbigene:135948
IL8RB GeneProduct ncbigene:3579
OR2B2 GeneProduct ncbigene:81697
GPR174 GeneProduct ncbigene:84636
DRD3 GeneProduct ncbigene:1814
OR10H1 GeneProduct ncbigene:26539
Melatonin Metabolite hmdb:HMDB0001389
GPR74 GeneProduct ncbigene:10886
OR8D2 GeneProduct ncbigene:283160
GPR63 GeneProduct ncbigene:81491
PTGIR GeneProduct ncbigene:5739
OPN3 GeneProduct ncbigene:23596
GPR7 GeneProduct ncbigene:2831
GPR10 GeneProduct ncbigene:2834
GPR45 GeneProduct ncbigene:11250
CCRL2 GeneProduct ncbigene:9034
OPN1SW GeneProduct ncbigene:611
GPR81 GeneProduct ncbigene:27198
OR3A1 GeneProduct ncbigene:4994
CCR6 GeneProduct ncbigene:1235
FSHR GeneProduct ncbigene:2492
GPR77 GeneProduct ncbigene:27202
AVPR1B GeneProduct ncbigene:553
IL8RA GeneProduct ncbigene:3577
P2RY14 GeneProduct ncbigene:9934
GPR3 GeneProduct ncbigene:2827
OR2A4 GeneProduct ncbigene:79541
OR10J1 GeneProduct ncbigene:26476
FPRL2 GeneProduct ncbigene:2359
OPRD1 GeneProduct ncbigene:4985
OR1A1 GeneProduct ncbigene:8383
HRH3 GeneProduct ncbigene:11255
GPR44 GeneProduct ncbigene:11251
P2RY11 GeneProduct ncbigene:5032
GPR23 GeneProduct ncbigene:2846
ADORA2B GeneProduct ncbigene:136
F2RL2 GeneProduct ncbigene:2151
OR2J3 GeneProduct ncbigene:442186
Serotonin Metabolite cas:50-67-9
OR5I1 GeneProduct ncbigene:10798
GPR40 GeneProduct ncbigene:2864
CCBP2 GeneProduct ncbigene:1238
CCKBR GeneProduct ncbigene:887
NPY5R GeneProduct ncbigene:4889
ADRB3 GeneProduct ncbigene:155
OR2D2 GeneProduct ncbigene:120776
ADRA1A GeneProduct ncbigene:148
CMKOR1 GeneProduct ncbigene:57007
GPR43 GeneProduct ncbigene:2867
OR7A5 GeneProduct ncbigene:26659
OR10H2 GeneProduct ncbigene:26538
GPR87 GeneProduct ncbigene:53836
GALR3 GeneProduct ncbigene:8484
OR2J1 GeneProduct ncbigene:442185
OR2N1P GeneProduct ncbigene:26701
HTR2A GeneProduct ncbigene:3356
CHRM3 GeneProduct ncbigene:1131
BRS3 GeneProduct ncbigene:680
EDNRA GeneProduct ncbigene:1909
OR3A2 GeneProduct ncbigene:4995
CCR2 GeneProduct ncbigene:729230
OR2T1 GeneProduct ncbigene:26696
OR1D4 GeneProduct ncbigene:653166
AGTRL1 GeneProduct ncbigene:187
MC2R GeneProduct ncbigene:4158
DRD5 GeneProduct ncbigene:1816
GPR21 GeneProduct ncbigene:2844
P2RY5 GeneProduct ncbigene:10161
TBXA2R GeneProduct ncbigene:6915
ADRB2 GeneProduct ncbigene:154
ADRA1D GeneProduct ncbigene:146
OR1A2 GeneProduct ncbigene:26189
SUCNR1 GeneProduct ncbigene:56670
MC3R GeneProduct ncbigene:4159
PTGDR GeneProduct ncbigene:5729
CYSLTR1 GeneProduct ncbigene:10800
GPR30 GeneProduct ncbigene:2852
GPR4 GeneProduct ncbigene:2828
ADRA2B GeneProduct ncbigene:151
GPR20 GeneProduct ncbigene:2843
CCR1 GeneProduct ncbigene:1230
NTSR1 GeneProduct ncbigene:4923
AGTR2 GeneProduct ncbigene:186
C3AR1 GeneProduct ncbigene:719
MC4R GeneProduct ncbigene:4160
AVPR2 GeneProduct ncbigene:554
GPR27 GeneProduct ncbigene:2850
CHRM1 GeneProduct ncbigene:1128
HRH1 GeneProduct ncbigene:3269
Angiotensin II Metabolite hmdb:HMDB0001035
PPYR1 GeneProduct ncbigene:5540
AVPR1A GeneProduct ncbigene:552
CCR10 GeneProduct ncbigene:2826
GHSR GeneProduct ncbigene:2693
OR2AG1 GeneProduct ncbigene:144125
OR2F1 GeneProduct ncbigene:26211
GPR147 GeneProduct ncbigene:64106
HTR7 GeneProduct ncbigene:3363
HRH2 GeneProduct ncbigene:3274
P2RY12 GeneProduct ncbigene:64805
HTR2C GeneProduct ncbigene:3358
GPR171 GeneProduct ncbigene:29909
OR1Q1 GeneProduct ncbigene:158131
MAS1 GeneProduct ncbigene:4142
MC5R GeneProduct ncbigene:4161
DRD1 GeneProduct ncbigene:1812
GPR18 GeneProduct ncbigene:2841
CCKAR GeneProduct ncbigene:886
OPN1LW GeneProduct ncbigene:5956
EDNRB GeneProduct ncbigene:1910
Q9UDD9 GeneProduct uniprot:Q9UDD9
BDKRB1 GeneProduct ncbigene:623
OR11A1 GeneProduct ncbigene:26531
OR1E1 GeneProduct ncbigene:8387
BDKRB2 GeneProduct ncbigene:624
OR2C1 GeneProduct ncbigene:4993
GPR83 GeneProduct ncbigene:10888
NPY2R GeneProduct ncbigene:4887
SSTR3 GeneProduct ncbigene:6753
HTR1D GeneProduct ncbigene:3352
OR6B1 GeneProduct ncbigene:135946
CXCR4 GeneProduct ncbigene:7852
GPR75 GeneProduct ncbigene:10936
Histamine Metabolite cas:51-45-6
CCR5 GeneProduct ncbigene:1234
GPR12 GeneProduct ncbigene:2835
CCR7 GeneProduct ncbigene:1236
GPR25 GeneProduct ncbigene:2848
CCR9 GeneProduct ncbigene:10803
OR2H1 GeneProduct ncbigene:26716
OR1I1 GeneProduct ncbigene:126370
CHRM5 GeneProduct ncbigene:1133
OR3A4 GeneProduct ncbigene:390756

References

  1. Horn F, Weare J, Beukers MW, Hörsch S, Bairoch A, Chen W, et al. GPCRDB: an information system for G protein-coupled receptors. Nucleic Acids Res. 1998 Jan 1;26(1):275–9. PubMed Europe PMC Scholia
  2. Karchin R, Karplus K, Haussler D. Classifying G-protein coupled receptors with support vector machines. Bioinformatics. 2002 Jan;18(1):147–59. PubMed Europe PMC Scholia