Overview of interferons-mediated signaling pathway (WP4558)

Interferons (IFNs) can be devided in three classes, Type I, II and III. Type I IFNs are created when the cell surface or specific receptors recognize microbial products; these are structural homologues of one another which bind the same receptor. Binding to this receptor leads to an activation of kinases which regulate the phosphorylation and therefore activation of some STAT proteins (see PW for details). There is only 1 Type II interferon, INF-gamma, consisting of two subunits (R1 and R2), which associate with Jak 1 and 2, respectively. Activation of Jak1 and Jak2 leads to phosphorylation of STAT1, which ultimately binds to IFN-gamma-activated sequence (GAS) elements, regulating the transcription of genes. Type III interferons are considered a protein family of 4, which bind to a different receptor compared to Type I interferons, however they trigger the same STAT1+2 phosphorylation reactions as TypeI IFNs.
last edited

Authors

Azkalaty, Andra, DeSl, and Khanspers

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: type II interferon signaling pathway type I interferon signaling pathway signaling pathway

Participants

Label Type Compact Identifier
JAK1 GeneProduct ncbigene:3716
JAK1 GeneProduct ncbigene:3716
TYK2 GeneProduct ncbigene:7297
JAK2 GeneProduct ncbigene:3717
STAT1 GeneProduct ncbigene:6772
STAT1 GeneProduct ncbigene:6772
STAT1 GeneProduct ncbigene:6772
STAT2 GeneProduct ncbigene:6773
STAT1 GeneProduct ncbigene:6772
STAT2 GeneProduct ncbigene:6773
JAK1 GeneProduct ncbigene:3716
PIK3R1 GeneProduct ncbigene:5295
PIK3CA GeneProduct ncbigene:5290
PRKCA GeneProduct ncbigene:5578
IRF9 GeneProduct ncbigene:10379
IRF9 GeneProduct ncbigene:10379
IFNAR2 GeneProduct ncbigene:3455
IFNAR1 GeneProduct ncbigene:3454
IFNGR1 GeneProduct ncbigene:3459
IFNGR2 GeneProduct ncbigene:3460
IFNA1 GeneProduct ncbigene:3439
IFNA7 GeneProduct ncbigene:3444
IFNG GeneProduct ncbigene:3458
JAK1 GeneProduct ncbigene:3716
TYK2 GeneProduct ncbigene:7297
STAT1 GeneProduct ncbigene:6772
STAT2 GeneProduct ncbigene:6773
IFNLR1 GeneProduct ncbigene:163702
IL10RB GeneProduct ncbigene:3588
IFNL1 GeneProduct ncbigene:282618
IFNL2 GeneProduct ncbigene:282616
IFNL3 GeneProduct ncbigene:282617
IFNL4 GeneProduct ncbigene:101180976
IFNA5 GeneProduct ncbigene:3442
IFNA6 GeneProduct ncbigene:3443
IFNA4 GeneProduct ncbigene:3441
IFNA2 GeneProduct ncbigene:3440
IFNA8 GeneProduct ncbigene:3445
IFNA10 GeneProduct ncbigene:3446
IFNA13 GeneProduct ncbigene:3447
IFNA14 GeneProduct ncbigene:3448
IFNA16 GeneProduct ncbigene:3449
IFNA17 GeneProduct ncbigene:3451
IFNA21 GeneProduct ncbigene:3452
IFNB1 GeneProduct ncbigene:3456
IFNE GeneProduct ncbigene:338376
IFNW1 GeneProduct ncbigene:3467
IFNK GeneProduct ncbigene:56832
STAT1 GeneProduct ncbigene:6772
STAT2 GeneProduct ncbigene:6773
IRF9 GeneProduct ncbigene:10379
STAT1 GeneProduct ncbigene:6772
STAT2 GeneProduct ncbigene:6773
STAT1 GeneProduct ncbigene:6772
STAT1 GeneProduct ncbigene:6772
STAT1 GeneProduct ncbigene:6772
STAT1 GeneProduct ncbigene:6772

References

  1. Platanias LC. Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol. 2005 May;5(5):375–86. PubMed Europe PMC Scholia
  2. Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I. Direct effects of type I interferons on cells of the immune system. Clin Cancer Res. 2011 May 1;17(9):2619–27. PubMed Europe PMC Scholia
  3. Mesev EV, LeDesma RA, Ploss A. Decoding type I and III interferon signalling during viral infection. Nat Microbiol. 2019 Jun;4(6):914–24. PubMed Europe PMC Scholia