Interactions between immune cells and microRNAs in tumor microenvironment (WP4559)

The interplay between immune cells and microRNAs in the tumor microenvironment (TME). MRX34 and MRG‐106 (cobomarsen) are miRNA therapeutic agents. Adapted from figure 1 in [https://www.ncbi.nlm.nih.gov/pubmed/30578699 Cortez et al].
last edited

Authors

Khanspers and DeSl

Cited In

Organism

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology: antigen processing and presentation pathway immune response pathway

Cell Type Ontology: lymphocyte macrophage natural killer cell natural T-regulatory cell T cell

Disease Ontology: cancer

Participants

Label Type Compact Identifier
MHC GeneProduct None
MRX34 Metabolite None
MIR155 Rna ensembl:ENSG00000283904
TLR4 GeneProduct ensembl:ENSG00000136869
TRA GeneProduct ncbigene:6955
TGFBR2 GeneProduct ensembl:ENSG00000163513
SOCS1 GeneProduct ensembl:ENSG00000185338
IL2RA GeneProduct ensembl:ENSG00000134460
LPS Metabolite chebi:52603
CTLA4 GeneProduct ensembl:ENSG00000163599
CD80 GeneProduct ensembl:ENSG00000121594
CD86 GeneProduct ensembl:ENSG00000114013
MIR138-1 GeneProduct ensembl:ENSG00000207954
MIR138-2 GeneProduct ensembl:ENSG00000207649
PDCD1 GeneProduct ensembl:ENSG00000188389
MIR212 GeneProduct ensembl:ENSG00000267195
MIR203A GeneProduct ensembl:ENSG00000207568
MIR203B GeneProduct ensembl:ENSG00000283165
MRG-106(cobomarsen) Metabolite None
MIR34A GeneProduct ensembl:ENSG00000284357
MIR138-1 GeneProduct ensembl:ENSG00000207954
MIR138-2 GeneProduct ensembl:ENSG00000207649
CD274 GeneProduct ensembl:ENSG00000120217
MIR200A GeneProduct hgnc.symbol:MIR200A
MIR200B GeneProduct ensembl:ENSG00000207730
MIR200C GeneProduct ensembl:ENSG00000207713
MIR155 Rna ensembl:ENSG00000283904
MIR21 GeneProduct ensembl:ENSG00000284190
PIAS3 GeneProduct ensembl:ENSG00000131788
STAT3 GeneProduct ensembl:ENSG00000168610
CCL5 GeneProduct ensembl:ENSG00000271503
CXCL10 GeneProduct ensembl:ENSG00000169245
CCL2 GeneProduct ensembl:ENSG00000108691
TGFB1 GeneProduct ensembl:ENSG00000105329
TGFB2 GeneProduct ensembl:ENSG00000092969
TGFB3 GeneProduct ensembl:ENSG00000119699
IL2RB GeneProduct ensembl:ENSG00000100385
IL2RG GeneProduct ensembl:ENSG00000147168
TRB GeneProduct ncbigene:6957
CCL5 GeneProduct ensembl:ENSG00000271503
CXCL10 GeneProduct ensembl:ENSG00000169245
MIR24-1 GeneProduct ensembl:ENSG00000284459
MIR24-2 GeneProduct ensembl:ENSG00000284387
MIR214 GeneProduct ensembl:ENSG00000283844
CCL2 GeneProduct ensembl:ENSG00000108691
MIRLET7D GeneProduct ensembl:ENSG00000199133
MIR210 GeneProduct ensembl:ENSG00000199038
MIR23A GeneProduct ensembl:ENSG00000207980
MIR21 GeneProduct ensembl:ENSG00000284190
MIR29A GeneProduct ensembl:ENSG00000284032
IRAK4 GeneProduct ensembl:ENSG00000198001
TRAF6 GeneProduct ensembl:ENSG00000175104
MIR21 GeneProduct ensembl:ENSG00000284190
STAT3 GeneProduct ensembl:ENSG00000168610
MIR24-2 GeneProduct ensembl:ENSG00000284387
MIR23A GeneProduct ensembl:ENSG00000207980
MIR27A GeneProduct ensembl:ENSG00000207808
STAT6 GeneProduct ensembl:ENSG00000166888
MIR146A GeneProduct ensembl:ENSG00000283733
TLR7 GeneProduct ensembl:ENSG00000196664
TLR8 GeneProduct ensembl:ENSG00000101916
NFKB1 GeneProduct ensembl:ENSG00000109320
NFKB2 GeneProduct ensembl:ENSG00000077150
IL4 GeneProduct ensembl:ENSG00000113520
IL4R GeneProduct ensembl:ENSG00000077238

References

  1. Cortez MA, Anfossi S, Ramapriyan R, Menon H, Atalar SC, Aliru M, et al. Role of miRNAs in immune responses and immunotherapy in cancer. Genes Chromosomes Cancer. 2019 Apr;58(4):244–53. PubMed Europe PMC Scholia