Major receptors targeted by epinephrine and norepinephrine (WP4589)

The physiologic "fear" response is associated with the signaling activity of adrenergic receptors stimulated by epinephrine/norepinephrine.
last edited


Chris, Egonw, Fehrhart, DeSl, AlexanderPico, Khanspers, and Finterly

Cited In


Homo sapiens



Pathway Ontology: epinephrine signaling pathway classic metabolic pathway norepinephrine signaling pathway


Label Type Compact Identifier
β2 receptor Protein uniprot:P07550
β1 receptor Protein uniprot:P08588
PKC Protein eccode:
α1A receptor Protein uniprot:P3548
calcium Metabolite chebi:22984
ATP Metabolite chebi:30616
Epinephrine Metabolite wikidata:Q132621
Norepinephrine Metabolite None
Neurotransmitters Pathway wikipathways:WP4220
Serine Metabolite chebi:17115
α2A receptor Protein uniprot:P08913
PKA Protein eccode:
Glycolysis Pathway wikipathways:WP534
Glycogen synthesis Pathway wikipathways:WP500
ADCY1 Protein uniprot:Q08828
PIP3 Metabolite None
DAG Metabolite wikidata:Q161466
AC Protein eccode:
α1B receptor Protein uniprot:P3568
α1D receptor Protein uniprot:P25100
α2B receptor Protein uniprot:P18089
α2C receptor Protein uniprot:P18825
IP3 Metabolite None
AC Protein eccode:
pyro-phosphate Metabolite chebi:33019
cAMP Metabolite chebi:58165
AC Protein eccode:
ADCY2 Protein uniprot:Q08462
ADCY3 Protein uniprot:O60266
ADCY4 Protein uniprot:Q8NFM4
ADCY5 Protein uniprot:O95622
ADCY6 Protein uniprot:O43306
ADCY7 Protein uniprot:P51828
ADCY8 Protein uniprot:P40145
ADCY9 Protein uniprot:O60503
ADCY10 Protein uniprot:Q96PN6
Threonine Metabolite chebi:57926
Serine Metabolite chebi:17115
Threonine Metabolite chebi:57926
Glycogen breakdown Pathway wikipathways:WP500