Blood clotting cascade (WP460)

Coagulation is a complex process by which blood forms clots. It is an important part of hemostasis (the cessation of blood loss from a damaged vessel), wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel. Disorders of coagulation can lead to an increased risk of bleeding (hemorrhage) or clotting (thrombosis). Source: [[wikipedia:Coagulation|Wikipedia]]
last edited


A.Kwa, MaintBot, Thomas, Christine Chichester, and Eweitz

Cited In


Mus musculus



Pathway Ontology: coagulation cascade pathway


Label Type Compact Identifier
F10 GeneProduct ncbigene:14058
F2 GeneProduct ncbigene:14061
F12 GeneProduct ncbigene:58992
Fibrin Metabolite None
Fgg GeneProduct ncbigene:99571
F10 GeneProduct ncbigene:14058
Plg GeneProduct ncbigene:18815
F9 GeneProduct ncbigene:14071
F8a GeneProduct ncbigene:14070
Plau GeneProduct ncbigene:18792
Fgb GeneProduct ncbigene:110135
Vwf GeneProduct ncbigene:22371
F5 GeneProduct ncbigene:14067
F13b GeneProduct ncbigene:14060
F11 GeneProduct ncbigene:109821
Serpinf2 GeneProduct ncbigene:18816
Plat GeneProduct ncbigene:18791
Serpinb2 GeneProduct ncbigene:18788
Prothrombinase Complex GeneProduct None
Serpine1 GeneProduct ncbigene:18787
F8 GeneProduct ncbigene:14069
F7 GeneProduct ncbigene:14068
Fga GeneProduct ncbigene:14161


  1. Luchtman-Jones L, Broze GJ Jr. The current status of coagulation. Ann Med. 1995 Feb;27(1):47–52. PubMed Europe PMC Scholia