Aerobic glycolysis (WP4629)

Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO- and H+. The free energy released in this process is used to form the ATP and NADH. This pathway was made during a research project at the UMCG, concerning changed glycolytic fluxes during the Warburg Effect. It is an extended version of the glycolysis pathway (WP534), and is descriptive of the content that is provided in the computer model of Shestov et al (2014). A second version, containing the content of the model itself as well as the corresponding supplement and article, can be found here [https://www.wikipathways.org/index.php/Pathway:WP4628] This pathway was uploaded to provide a high resolution version to readers of the thesis. Description and pathway adapted from [https://www.wikipathways.org/index.php/Pathway:WP534] Referred article: Shestov et al., 2014 [https://www.ncbi.nlm.nih.gov/pubmed/25009227]
last edited

Authors

KJanssen, Egonw, AlexanderPico, DeSl, MaintBot, Eweitz, and Finterly

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: glycolysis/gluconeogenesis pathway gluconeogenesis pathway

Participants

Label Type Compact Identifier
ATP Metabolite chebi:15422
AMP Metabolite chebi:16027
O2e Metabolite chebi:26689
H Metabolite chebi:49637
HK GeneProduct ncbigene:3098
GLUT GeneProduct ncbigene:6513
_2PG Metabolite hmdb:HMDB0000362
BPG Metabolite hmdb:HMDB0001270
PYR Metabolite hmdb:HMDB0000243
GAP Metabolite hmdb:HMDB0001112
PGK GeneProduct ncbigene:5230
ENO GeneProduct ncbigene:2023
ATP Metabolite chebi:15422
GPI GeneProduct ncbigene:2821
LDH GeneProduct ncbigene:3939
G6P Metabolite chebi:75052
LAC Metabolite hmdb:HMDB0000190
PEP Metabolite hmdb:HMDB0000263
PK GeneProduct ncbigene:5315
_3PG Metabolite hmdb:HMDB0000807
H Metabolite chebi:49637
GLU Metabolite hmdb:HMDB0000122
F6P Metabolite chebi:61527
DHAP Metabolite hmdb:HMDB0001473
ALD GeneProduct ncbigene:226
PFK GeneProduct ncbigene:5213
GLUe Metabolite hmdb:HMDB0000122
GAPDH GeneProduct ensembl:ENSG00000111640
ADP Metabolite chebi:16761
FBP Metabolite hmdb:HMDB0001058
PGM GeneProduct ncbigene:5224
TPI GeneProduct ncbigene:7167
ATP Metabolite chebi:15422
ADP Metabolite chebi:16761
AMP Metabolite chebi:16027
NAD Metabolite chebi:15846
P Metabolite chebi:28659
NADH Metabolite chebi:16908
H Metabolite chebi:49637
ATP Metabolite chebi:15422
ADP Metabolite chebi:16761
ATP Metabolite chebi:15422
ADP Metabolite chebi:16761
LACe Metabolite hmdb:HMDB0000190
NAD Metabolite chebi:15846
NADH Metabolite chebi:16908
LACT GeneProduct ncbigene:0
ADP Metabolite chebi:16761
P Metabolite chebi:28659
ATP Metabolite chebi:15422
O2 Metabolite chebi:26689
OXPHOS Unknown None
O2 Metabolite chebi:26689
NADH Metabolite chebi:16908
MAS Unknown None
ADP Metabolite chebi:16761
P Metabolite chebi:28659
ATP Metabolite chebi:15422
NAD Metabolite chebi:15846
OXYT Unknown None
ATP Metabolite chebi:15422
ATPase GeneProduct None
ADP Metabolite chebi:16761
H Metabolite chebi:49637
P Metabolite chebi:28659
ADP Metabolite chebi:16761
ADP Metabolite chebi:16761
AK GeneProduct None
PYR Metabolite hmdb:HMDB0000243
Pathway Pathway wikipathways:0
Metabolite Metabolite None
Enzyme GeneProduct ncbigene:2821
NAD Metabolite chebi:15846
P Metabolite chebi:28659
H Metabolite chebi:49637
ATP Metabolite chebi:15422
Metabolite Metabolite None

References

  1. Carbonell J, Felíu JE, Marco R, Sols A. Pyruvate kinase. Classes of regulatory isoenzymes in mammalian tissues. Eur J Biochem. 1973 Aug 1;37(1):148–56. PubMed Europe PMC Scholia
  2. Hüttemann M, Lee I, Samavati L, Yu H, Doan JW. Regulation of mitochondrial oxidative phosphorylation through cell signaling. Biochim Biophys Acta. 2007 Dec;1773(12):1701–20. PubMed Europe PMC Scholia