Tryptophan metabolism (WP465)

This pathway describes the metabolism of tryptophan, an essential amino acid. Converted from rat to human using ortholog information. Originally adapted from: [https://www.genome.jp/dbget-bin/www_bget?pathway+rno00380 KEGG]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP465 CPTAC Assay Portal].
last edited

Authors

L.M.Ferrante, MaintBot, AlexanderPico, Khanspers, AdrienDefay, Egonw, DeSl, Fehrhart, and Finterly

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: tryptophan metabolic pathway

Participants

Label Type Compact Identifier
4-(2-Aminophenyl)-2,4-dioxobutanoate Metabolite chemspider:19951260
Indolelactate Metabolite chemspider:28571995
2-Aminomuconate Metabolite None
3-Methylindolepyruvate Metabolite chebi:28549
7,8-Dihydro-7,8-dihydroxykynurenate Metabolite None
Indole-3-acetate Metabolite chemspider:779
Oxaloacetate Metabolite chemspider:2509917
5-Hydroxyindolepyruvate Metabolite chebi:27597
Anthranilate Metabolite chemspider:4573598
3-Indoleglycolaldehyde Metabolite chemspider:388979
Glucobrassicin Metabolite None
Indolepyruvate Metabolite chemspider:24775813
5-hydroxykynurenamine Metabolite chebi:62214
3-Hydroxy-L-kynurenine Metabolite None
5-Methoxyindoleacetate Metabolite chemspider:14533147
3-Methyldioxyindole Metabolite chebi:28254
2-Aminomuconate Metabolite None
N-acetylindoxyl Metabolite chebi:15363
4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate Metabolite chemspider:389617
C01144 Metabolite None
Indole-3-ethanol Metabolite chemspider:10235
3-Hydroxyanthranilate Metabolite chemspider:7822291
Indole-3-acetaldoxime Metabolite chemspider:388896
2-Formylaminobenzaldehyde Metabolite chemspider:389
N-formylanthranilate Metabolite wikidata:Q27103061
4,8-Dihydroxyquinoline Metabolite chebi:28883
Isophenoxazine Metabolite None
6-Hydroxyindolelactate Metabolite chebi:27524
3-Hydroxykynurenamine Metabolite hmdb:HMDB0060281
Anthranilate Metabolite chemspider:4573598
5-(3-Carboxy-3-oxopropenyl)-4,6-dihydroxypicolin Metabolite None
2-Formaminobenzoylacetate Metabolite None
6-Hydroxykynurenate Metabolite None
Indole-3-acetaldehyde Metabolite chemspider:778
L-Tryptophanyl-tRNA Metabolite None
Quinolinate Metabolite chemspider:2777129
Cinnavalininate Metabolite None
Formyl-5-hydroxykynurenamine Metabolite hmdb:HMDB0012948
3-Methoxyanthranilate Metabolite chemspider:7827589
2-Oxoglutarate Metabolite chemspider:144236
2-Oxoadipate Metabolite chemspider:19951093
7,8-Dihydroxykynurenate Metabolite None
5-Hydroxyindoleacetate Metabolite chemspider:10637170
5-(3-Carboxy-3-oxopropyl) -4,6-dihydroxypicolinate Metabolite chemspider:30791292
3-(2-Aminoethyl)-1H-indol-5-ol Metabolite chemspider:5013
Benzoate degradation via hydroxylation Metabolite None
(Z)-5-Oxohex-2-enedioate Metabolite None
5-(2-Formylethyl)-4,6-dihydroxypicolinate Metabolite Chemspider
Formyl-N-acetyl-5-methoxykynurenamine Metabolite None
8-Methoxykynurenate Metabolite None
Kynurenate Metabolite chebi:18344
2,3-Dihydroxyindole Metabolite chemspider:20546
2-Amino-3-carboxymuconate Metabolite None
5-Hydroxyindoleacetylglycine Metabolite None
CYP4F12 GeneProduct ncbigene:66002
4.2.1.84 GeneProduct eccode:4.2.1.84
INDO GeneProduct ncbigene:3620
CYP2E1 GeneProduct ncbigene:1571
GCDH GeneProduct ncbigene:2639
ALDH9A1 GeneProduct ncbigene:223
HRMT1L2 GeneProduct ncbigene:3276
ALDH2 GeneProduct ncbigene:217
ALDH1A2 GeneProduct ncbigene:8854
Formylkynurenine Metabolite cas:1022-31-7
2.6.1.27 GeneProduct eccode:2.6.1.27
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate Metabolite hmdb:HMDB0004083
4.1.1.- GeneProduct eccode:4.1.1.-
1.13.11.10 GeneProduct eccode:1.13.11.10
Cyp2d2 GeneProduct None
ASMT GeneProduct ncbigene:438
Acetyl-CoA Metabolite cas:72-89-9
1.14.16.- GeneProduct eccode:1.14.16.-
Indole Metabolite cas:120-72-9
1.5.1.- GeneProduct eccode:1.5.1.-
CYP1A1 GeneProduct ncbigene:1543
OGDH GeneProduct ncbigene:4967
1.7.3.2 GeneProduct eccode:1.7.3.2
MAOB GeneProduct ncbigene:4129
ALDH3A2 GeneProduct ncbigene:224
MAOB GeneProduct ncbigene:4129
DDC GeneProduct ncbigene:1644
HADH2 GeneProduct ncbigene:3028
ALDH9A1 GeneProduct ncbigene:223
CAT GeneProduct ncbigene:847
5-Methoxytryptamine Metabolite cas:608-07-1
5-Hydroxy-L-tryptophan Metabolite hmdb:HMDB0000472
1.13.11.- GeneProduct eccode:1.13.11.-
Glycolysis/Gluconeogenesis Pathway wikipathways:WP534
HADHSC GeneProduct ncbigene:3033
CYP3A4 GeneProduct ncbigene:1576
Nicotinate and nicotinamide metabolism Pathway None
ALDH3A2 GeneProduct ncbigene:224
2.1.1.47 GeneProduct eccode:2.1.1.47
DDC GeneProduct ncbigene:1644
1.13.11.23 GeneProduct eccode:1.13.11.23
DDC GeneProduct ncbigene:1644
ALDH2 GeneProduct ncbigene:217
MAOB GeneProduct ncbigene:4129
1.1.1.110 GeneProduct eccode:1.1.1.110
1.2.3.7 GeneProduct eccode:1.2.3.7
CYP7B1 GeneProduct ncbigene:9420
AADAT GeneProduct ncbigene:51166
1.10.3.4 GeneProduct eccode:1.10.3.4
ACAT1 GeneProduct ncbigene:38
INDO GeneProduct ncbigene:3620
ALDH1A2 GeneProduct ncbigene:8854
4.1.1.43 GeneProduct eccode:4.1.1.43
L-Kynurenine Metabolite cas:343-65-7
KYNU GeneProduct ncbigene:8942
1.14.99.2 GeneProduct eccode:1.14.99.2
AFMID GeneProduct ncbigene:125061
CYP1B1 GeneProduct ncbigene:1545
Melatonin Metabolite hmdb:HMDB0001389
2.6.1.27 GeneProduct eccode:2.6.1.27
1.13.11.17 GeneProduct eccode:1.13.11.17
AANAT GeneProduct ncbigene:15
1.2.1.32 GeneProduct eccode:1.2.1.32
Benzoate degradation via hydroxylation Pathway None
AOX1 GeneProduct ncbigene:316
DHCR24 GeneProduct ncbigene:1718
3.2.1.147 GeneProduct eccode:3.2.1.147
4.1.99.1 GeneProduct eccode:4.1.99.1
5-Hydroxykynurenine Metabolite cas:484-78-6
AADAT GeneProduct ncbigene:51166
ACMSD GeneProduct ncbigene:130013
Xanthurenic acid Metabolite hmdb:HMDB0000881
N-Methylserotonin Metabolite hmdb:HMDB0004369
INDO GeneProduct ncbigene:3620
1.14.13.9 GeneProduct eccode:1.14.13.9
Tryptamine Metabolite cas:61-54-1
3.5.99.5 GeneProduct eccode:3.5.99.5
KYNU GeneProduct ncbigene:8942
CYP1A2 GeneProduct ncbigene:1544
CYP2C18 GeneProduct ncbigene:1562
5-Hydroxy-N-formylkynurenine Metabolite hmdb:HMDB0004086
4,6-Dihydroxyquinoline Metabolite hmdb:HMDB0004077
Cyp2b15 GeneProduct None
WARS GeneProduct ncbigene:7453
N-Acetylisatin Metabolite cas:574-17-4
CYP2A13 GeneProduct ncbigene:1553
Aldh1a4 GeneProduct None
INMT GeneProduct ncbigene:11185
CYP19A1 GeneProduct ncbigene:1588
L-Tryptophan Metabolite cas:73-22-3
HRMT1L2 GeneProduct ncbigene:3276
Indole-3-acetamide Metabolite cas:879-37-8
1.1.1.190 GeneProduct eccode:1.1.1.190
ALDH1A1 GeneProduct ncbigene:216
3.5.1.49 GeneProduct eccode:3.5.1.49
Acetoacetyl-CoA Metabolite kegg.compound:C00332
N-Methyltryptamine Metabolite chebi:28136
3.5.5.1 GeneProduct eccode:3.5.5.1
Phenylalanine, Tyrosine and Tryptophan metabolism Pathway None
CYP2J2 GeneProduct ncbigene:1573
Cyp2c12 GeneProduct None
3.5.1.4 GeneProduct eccode:3.5.1.4
Crotonoyl-CoA Metabolite kegg.compound:C00877
HAAO GeneProduct ncbigene:23498
5-(2-Carboxyethyl)-4,6-Dihydroxypicolinate Metabolite HMDB
3-Indoleacetonitrile Metabolite CAS
HRMT1L2 GeneProduct Entrez Gene
1.3.1.18 GeneProduct Enzyme Nomenclature
ABP1 GeneProduct Entrez Gene
1.4.3.2 GeneProduct Enzyme Nomenclature
5-Hydroxyindoleacetaldehyde Metabolite HMDB
MAOB GeneProduct Entrez Gene
KYNU GeneProduct Entrez Gene
Cyp2a1 GeneProduct None
2-Aminophenol Metabolite CAS
2.1.1.49 GeneProduct Enzyme Nomenclature
1.14.16.3 GeneProduct Enzyme Nomenclature
ECHS1 GeneProduct Entrez Gene
TDO2 GeneProduct Entrez Gene
CYP2F1 GeneProduct Entrez Gene
GCDH GeneProduct Entrez Gene
TPH1 GeneProduct Entrez Gene
6-Hydroxymelatonin Metabolite CAS
Glutaryl-CoA Metabolite KEGG Compound
Cyp2c39 GeneProduct None
Aldh1a4 GeneProduct None
2.6.1.27 GeneProduct Enzyme Nomenclature
1.2.1.- GeneProduct Enzyme Nomenclature
N-Acetylserotonin Metabolite CAS
1.13.12.3 GeneProduct Enzyme Nomenclature
ALDH1A1 GeneProduct Entrez Gene
1.13.99.3 GeneProduct Enzyme Nomenclature
Cyp2a2 GeneProduct None
ASMT GeneProduct Entrez Gene
3.5.1.9 GeneProduct Enzyme Nomenclature
1.1.1.191 GeneProduct Enzyme Nomenclature
6.3.2.- GeneProduct Enzyme Nomenclature
None

References