Small cell lung cancer (WP4658)

Small cell lung carcinoma (SCLC) is a highly malignant cancer of the lung. Genes altered in small cell lung carcinoma: * TP53 is mutated in 70-90% of SCLCs. * RB1 is inactivated in most SCLCs. * PTEN is mutated in 2-10% of SCLCs. * MYC amplifications and amplification of MYC family members is found in 30% of SCLCs. * FHIT protein expression is lost due to Loss of heterozygocity (LOH) on chromosome arm 3p found in more than 80% of SCLCs. This description was adapted from [https://en.wikipedia.org/wiki/Small-cell_carcinoma Wikipedia].
last edited

Authors

Khanspers, MaintBot, Fehrhart, and Finterly

Cited In

Organism

Homo sapiens

Communities

CPTAC Diseases

Annotations

Pathway Ontology: signaling pathway small cell lung carcinoma pathway cancer pathway

Disease Ontology: cancer lung cancer

Participants

Label Type Compact Identifier
RXRA GeneProduct ensembl:ENSG00000186350
CKS1B GeneProduct ensembl:ENSG00000173207
Cell cycle Pathway None
rimiducid Metabolite wikidata:Q27279658
MYC GeneProduct ensembl:ENSG00000136997
CASP8 GeneProduct ensembl:ENSG00000064012
venetoclax Metabolite chebi:133021
Retinoic acid Metabolite chebi:6067
FHIT GeneProduct ensembl:ENSG00000189283
BID GeneProduct ensembl:ENSG00000015475
RARB GeneProduct ensembl:ENSG00000077092
RXRB GeneProduct ensembl:ENSG00000204231
RXRG GeneProduct ensembl:ENSG00000143171
TP53 GeneProduct ensembl:ENSG00000141510
p53 SignalingPathway Pathway None
CDKN1A GeneProduct ensembl:ENSG00000124762
BAX GeneProduct ensembl:ENSG00000087088
DDB2 GeneProduct ensembl:ENSG00000134574
POLK GeneProduct ensembl:ENSG00000122008
BAK1 GeneProduct ensembl:ENSG00000030110
GADD45G GeneProduct ensembl:ENSG00000130222
GADD45A GeneProduct ensembl:ENSG00000116717
GADD45B GeneProduct ensembl:ENSG00000099860
BCL2 GeneProduct ensembl:ENSG00000171791
BAX GeneProduct ensembl:ENSG00000087088
CYCS GeneProduct ensembl:ENSG00000172115
APAF1 GeneProduct ensembl:ENSG00000120868
CASP3 GeneProduct ensembl:ENSG00000164305
CASP9 GeneProduct ensembl:ENSG00000132906
CYCS GeneProduct ensembl:ENSG00000172115
CCNE1 GeneProduct ensembl:ENSG00000105173
CCNE2 GeneProduct ensembl:ENSG00000175305
CDK2 GeneProduct ensembl:ENSG00000123374
CDK6 GeneProduct ensembl:ENSG00000105810
RB1 GeneProduct ensembl:ENSG00000139687
CDK4 GeneProduct ensembl:ENSG00000135446
CCND1 GeneProduct ensembl:ENSG00000110092
E2F1 GeneProduct ensembl:ENSG00000101412
E2F2 GeneProduct ensembl:ENSG00000007968
E2F3 GeneProduct ensembl:ENSG00000112242
SKP1 GeneProduct ensembl:ENSG00000113558
CDKN1C GeneProduct ensembl:ENSG00000129757
CDKN1B GeneProduct ensembl:ENSG00000111276
CKS2 GeneProduct ensembl:ENSG00000123975
MAX GeneProduct ensembl:ENSG00000125952
CDKN2B GeneProduct ensembl:ENSG00000147883
ZBTB17 GeneProduct ensembl:ENSG00000116809
LAMA1 GeneProduct ncbigene:284217
COL4A4 GeneProduct ncbigene:1286
LAMA2 GeneProduct ncbigene:3908
LAMA5 GeneProduct ncbigene:3911
LAMB1 GeneProduct ncbigene:3912
LAMC3 GeneProduct ncbigene:10319
LAMB2 GeneProduct ncbigene:3913
LAMA3 GeneProduct ncbigene:3909
COL4A2 GeneProduct ncbigene:1284
LAMA4 GeneProduct ncbigene:3910
LAMB3 GeneProduct ncbigene:3914
COL4A5 GeneProduct ensembl:ENSG00000188153
COL4A6 GeneProduct ncbigene:1288
LAMC1 GeneProduct ncbigene:3915
FN1 GeneProduct ncbigene:2335
LAMC2 GeneProduct ncbigene:3918
COL4A1 GeneProduct ncbigene:1282
COL4A3 GeneProduct ensembl:ENSG00000169031
LAMB4 GeneProduct ensembl:ENSG00000091128
ITGB1 GeneProduct ncbigene:3688
ITGA6 GeneProduct ncbigene:3655
ITGA2 GeneProduct ncbigene:3673
ITGA2B GeneProduct ncbigene:3674
ITGA3 GeneProduct ncbigene:3675
ITGAV GeneProduct ncbigene:3685
PIK3R1 GeneProduct ncbigene:5295
PIP3 Metabolite hmdb:HMDB0004249
PTK2 GeneProduct ncbigene:5747
PIK3R3 GeneProduct ensembl:ENSG00000117461
PTEN GeneProduct ncbigene:5728
AKT2 GeneProduct ncbigene:208
PIK3R2 GeneProduct ncbigene:5296
PIK3CA GeneProduct ncbigene:5290
AKT1 GeneProduct ncbigene:207
PIK3CB GeneProduct ncbigene:5291
AKT3 GeneProduct ncbigene:10000
PIK3CD GeneProduct ncbigene:5293
IKBKG GeneProduct ensembl:ENSG00000269335
IKBKB GeneProduct ensembl:ENSG00000104365
CHUK GeneProduct ensembl:ENSG00000213341
NFKB1 GeneProduct ncbigene:4790
RELA GeneProduct ensembl:ENSG00000173039
NFKB1 GeneProduct ncbigene:4790
RELA GeneProduct ensembl:ENSG00000173039
NFKBIA GeneProduct ensembl:ENSG00000100906
NFKBIB GeneProduct ensembl:ENSG00000104825
NFKBIA GeneProduct ensembl:ENSG00000100906
NFKBIB GeneProduct ensembl:ENSG00000104825
Ubiquitin-mediated proteolysis Pathway wikipathways:WP183
CCND1 GeneProduct ensembl:ENSG00000110092
BIRC2 GeneProduct ensembl:ENSG00000110330
BIRC3 GeneProduct ensembl:ENSG00000023445
BIRC7 GeneProduct ensembl:ENSG00000101197
BIRC8 GeneProduct ensembl:ENSG00000163098
BCL2L1 GeneProduct ensembl:ENSG00000171552
TRAF2 GeneProduct ensembl:ENSG00000127191
TRAF3 GeneProduct ensembl:ENSG00000131323
TRAF4 GeneProduct ensembl:ENSG00000076604
TRAF5 GeneProduct ensembl:ENSG00000082512
TRAF6 GeneProduct ensembl:ENSG00000175104
TRAF1 GeneProduct ensembl:ENSG00000056558
PTGS2 GeneProduct ensembl:ENSG00000073756
NOS2 GeneProduct ensembl:ENSG00000007171
oblimersen Metabolite wikidata:Q27269650
Obatoclax Metabolite wikidata:Q7074645

References

  1. Deng W-G, Nishizaki M, Fang B, Roth JA, Ji L. Induction of apoptosis by tumor suppressor FHIT via death receptor signaling pathway in human lung cancer cells. Biochem Biophys Res Commun. 2007 Apr 20;355(4):993–9. PubMed Europe PMC Scholia