Head and neck squamous cell carcinoma (WP4674)
HNSCC, which includes malignant squamous lesions arising in the oral cavity, larynx and pharynx, is the seventh most common cancer in the world. HNSCC has a remarkable multiplicity and diversity of genetic alterations. Most genomic alterations in HNSCC converge in a handful of molecular pathways resulting in cell cycle deregulation, genomic instability, cell differentiation defects, and persistent mitogenic signaling, the latter involving aberrant PI3K/mTOR pathway activation thereby rendering HNSCC responsive to PI3K/mTOR inhibitors. Pathway is based on [https://europepmc.org/articles/PMC4348071 Fig 1 from Iglesias-Bartolome et al], [https://www.nature.com/articles/nature14129 Fig 5 from Li et al] and [https://clinicalgate.com/the-molecular-pathogenesis-of-head-and-neck-cancer/ Fig 33-3 from Clinicalgate]. Description is modified from [https://europepmc.org/articles/PMC4348071 Iglesias-Bartolome et al].
Authors
Kristina Hanspers , Egon Willighagen , Denise Slenter , Marvin Martens , Maintenance bot , and Eric WeitzCited In
Organism
Homo sapiensCommunities
CPTAC DiseasesAnnotations
Disease Ontology: head and neck carcinoma
Participants
References
- Iglesias-Bartolome R, Martin D, Gutkind JS. Exploiting the head and neck cancer oncogenome: widespread PI3K-mTOR pathway alterations and novel molecular targets. Cancer Discov. 2013 Jul;3(7):722–5. PubMed Europe PMC Scholia
- Li Z-X, Zheng Z-Q, Wei Z-H, Zhang L-L, Li F, Lin L, et al. Comprehensive characterization of the alternative splicing landscape in head and neck squamous cell carcinoma reveals novel events associated with tumorigenesis and the immune microenvironment. Theranostics. 2019 Oct 14;9(25):7648–65. PubMed Europe PMC Scholia