Sphingolipid metabolism (integrated pathway) (WP4690)
Overview PW
Authors
Denise Slenter , Maintenance bot , Eric Weitz , and Conroy lipidsCited In
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Organism
Mus musculusCommunities
Lipids and LIPID MAPSAnnotations
Pathway Ontology: sphingolipid biosynthetic pathway sphingolipid metabolic pathway sphingomyelin metabolic pathway
Participants
| Label | Type | Compact Identifier |
|---|---|---|
| ATP | Metabolite | chebi:30616 |
| 3-keto-sphinganine | Metabolite | lipidmaps:LMSP01020002 |
| Palmitoyl-CoA | Metabolite | lipidmaps:LMFA07050360 |
| Serine | Metabolite | pubchem.compound:5951 |
| Hexadecanal | Metabolite | lipidmaps:LMFA06000088 |
| Ethanolamine-phosphate | Metabolite | pubchem.compound:1015 |
| H2O | Metabolite | chebi:15377 |
| Sphingosine | Metabolite | lipidmaps:LMSP01010001 |
| Sphinganine | Metabolite | lipidmaps:LMSP01020001 |
| Sphinganine-1-phosphate | Metabolite | lipidmaps:LMSP01050002 |
| C16 SM | Metabolite | lipidmaps:LMSP03010003 |
| C16 GlcCer | Metabolite | lipidmaps:LMSP0501AA03 |
| C16DH SM | Metabolite | lipidmaps:LMSP03010004 |
| C16DH GlcCer | Metabolite | lipidmaps:LMSP0501AA04 |
| Sphingosine-1-phosphate | Metabolite | lipidmaps:LMSP01050001 |
| 1-Hexadecenal | Metabolite | lipidmaps:LMFA06000088 |
| CoA(16:0) | Metabolite | lipidmaps:LMFA07050360 |
| CoA(18:0) | Metabolite | lipidmaps:LMFA07050369 |
| CoA(20:0) | Metabolite | lipidmaps:LMFA07050329 |
| CoA(22:0) | Metabolite | lipidmaps:LMFA07050289 |
| CoA(24:0) | Metabolite | lipidmaps:LMFA07050372 |
| CoA(24:1) | Metabolite | lipidmaps:LMFA07050098 |
| C16DH-Cer | Metabolite | lipidmaps:LMSP02020001 |
| CoA(26:0) | Metabolite | lipidmaps:LMFA07050327 |
| CoA(26:1) | Metabolite | lipidmaps:LMFA07050099 |
| ADP | Metabolite | chebi:456216 |
| C16 Cer | Metabolite | lipidmaps:LMSP02010004 |
| C18 SM | Metabolite | lipidmaps:LMSP03010001 |
| C18 GlcCer | Metabolite | lipidmaps:LMSP0501AA05 |
| C18DH SM | Metabolite | lipidmaps:LMSP03010020 |
| C18DH GlcCer | Metabolite | lipidmaps:LMSP0501AA19 |
| C18DH-Cer | Metabolite | lipidmaps:LMSP02020008 |
| C18 Cer | Metabolite | lipidmaps:LMSP02010006 |
| C20 SM | Metabolite | lipidmaps:LMSP03010005 |
| C20 GlcCer | Metabolite | lipidmaps:LMSP0501AA06 |
| C20DH SM | Metabolite | lipidmaps:LMSP03010021 |
| C20DH GlcCer | Metabolite | lipidmaps:LMSP0501AA20 |
| C20DH-Cer | Metabolite | lipidmaps:LMSP02020009 |
| C20 Cer | Metabolite | lipidmaps:LMSP02010007 |
| C22 SM | Metabolite | lipidmaps:LMSP03010006 |
| C22 GlcCer | Metabolite | lipidmaps:LMSP0501AA07 |
| C22DH SM | Metabolite | lipidmaps:LMSP03010022 |
| C22DH GlcCer | Metabolite | lipidmaps:LMSP0501AA21 |
| C22DH-Cer | Metabolite | lipidmaps:LMSP02020010 |
| C22 Cer | Metabolite | lipidmaps:LMSP02010008 |
| C24 SM | Metabolite | lipidmaps:LMSP03010008 |
| C24 GlcCer | Metabolite | lipidmaps:LMSP0501AA09 |
| C24DH SM | Metabolite | lipidmaps:LMSP03010024 |
| C24DH GlcCer | Metabolite | lipidmaps:LMSP0501AA23 |
| C24DH-Cer | Metabolite | lipidmaps:LMSP02020012 |
| C24 Cer | Metabolite | lipidmaps:LMSP02010012 |
| C24:1 SM | Metabolite | lipidmaps:LMSP03010007 |
| C24:1 GlcCer | Metabolite | lipidmaps:LMSP0501AA08 |
| C24:1DH SM | Metabolite | lipidmaps:LMSP03010023 |
| C24:1DH GlcCer | Metabolite | lipidmaps:LMSP0501AA22 |
| C24:1DH-Cer | Metabolite | lipidmaps:LMSP02020011 |
| C24:1 Cer | Metabolite | lipidmaps:LMSP02010009 |
| C26:1 SM | Metabolite | lipidmaps:LMSP03010009 |
| C26:1 GlcCer | Metabolite | lipidmaps:LMSP0501AA10 |
| C26:1DH SM | Metabolite | lipidmaps:LMSP03010025 |
| C26:1DH GlcCer | Metabolite | lipidmaps:LMSP0501AA24 |
| C26:1DH-Cer | Metabolite | lipidmaps:LMSP02020013 |
| C26:1 Cer | Metabolite | lipidmaps:LMSP02010010 |
| C26 SM | Metabolite | lipidmaps:LMSP03010010 |
| C26 GlcCer | Metabolite | lipidmaps:LMSP0501AA11 |
| C26DH SM | Metabolite | lipidmaps:LMSP03010026 |
| C26DH GlcCer | Metabolite | lipidmaps:LMSP0501AA25 |
| C26DH-Cer | Metabolite | lipidmaps:LMSP02020014 |
| C26 Cer | Metabolite | lipidmaps:LMSP02010011 |
| Ethanolamine-phosphate | Metabolite | pubchem.compound:1015 |
| Ppap2a | Protein | ncbigene:19012 |
| Cerk | Protein | ncbigene:223753 |
| Sgpp1 | Protein | uniprot:Q9JI99 |
| Asah1 | Protein | uniprot:Q9WV54 |
| Sgms1 | Protein | ncbigene:208449 |
| Sphk2 | Protein | uniprot:Q9JIA7 |
| Sgpl1 | Protein | ncbigene:20397 |
| Ugcg | Protein | ncbigene:22234 |
| Sptlc1 | Protein | ncbigene:268656 |
| Sphk1 | Protein | uniprot:Q8CI15 |
| Degs1 | Protein | ncbigene:13244 |
| Kdsr | Protein | uniprot:Q6GV12 |
| Sptlc2 | Protein | uniprot:P97363 |
| CerS4 | Protein | ncbigene:67260 |
| CerS5 | Protein | uniprot:Q9D6K9 |
| CerS6 | Protein | uniprot:Q8C172 |
| Smpd1 | Protein | ncbigene:20597 |
| Degs2 | Protein | ncbigene:70059 |
| Sgms2 | Protein | ncbigene:74442 |
| Ppap2b | Protein | ncbigene:67916 |
| Ppap2c | Protein | ncbiprotein:50784 |
| Ugt8a | Protein | ncbigene:22239 |
| CerS1 | Protein | uniprot:P27545 |
| CerS4 | Protein | ncbigene:67260 |
| Cers2 | Protein | ncbigene:76893 |
| Cers3 | Protein | uniprot:Q1A3B0 |
| Sgpp2 | Protein | uniprot:Q810K3 |
| Sphk2 | Protein | uniprot:Q9JIA7 |
| Sphk1 | Protein | uniprot:Q8CI15 |
| Sgpl1 | Protein | ncbigene:20397 |
| CerS4 | Protein | ncbigene:67260 |
| Cers2 | Protein | ncbigene:76893 |
| CerS4 | Protein | ncbigene:67260 |
| CerS5 | Protein | uniprot:Q9D6K9 |
| CerS6 | Protein | uniprot:Q8C172 |
| Cerk | Protein | ncbigene:223753 |
| Ugcg | Protein | ncbigene:22234 |
| Smpd1 | Protein | ncbigene:20597 |
| Sgms1 | Protein | ncbigene:208449 |
| Sgms2 | Protein | ncbigene:74442 |
| Ugt8a | Protein | ncbigene:22239 |
| Cers3 | Protein | uniprot:Q1A3B0 |
References
- Le Stunff H, Peterson C, Thornton R, Milstien S, Mandala SM, Spiegel S. Characterization of murine sphingosine-1-phosphate phosphohydrolase. J Biol Chem. 2002 Mar 15;277(11):8920–7. PubMed Europe PMC Scholia
- Merrill AH Jr. De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. J Biol Chem. 2002 Jul 19;277(29):25843–6. PubMed Europe PMC Scholia
- Mizutani Y, Kihara A, Igarashi Y. Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem J. 2005 Aug 15;390(Pt 1):263–71. PubMed Europe PMC Scholia
- Lahiri S, Futerman AH. LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. J Biol Chem. 2005 Oct 7;280(40):33735–8. PubMed Europe PMC Scholia
- Lahiri S, Lee H, Mesicek J, Fuks Z, Haimovitz-Friedman A, Kolesnick RN, et al. Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. FEBS Lett. 2007 Nov 13;581(27):5289–94. PubMed Europe PMC Scholia
- Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. A mouse macrophage lipidome. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
- Gosejacob D, Jäger PS, Vom Dorp K, Frejno M, Carstensen AC, Köhnke M, et al. Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity. J Biol Chem. 2016 Mar 25;291(13):6989–7003. PubMed Europe PMC Scholia