Vitamin D-sensitive calcium signaling in depression (WP4698)

Depression has been linked to (lack of) sunlight exposure and raised intracellular calcium levels. In this pathway, the role of the vitamin D pathway in calcium signaling in depression is shown. Active 1,25-dihydroxy-vitamin D3 is formed from 7-dehydrocholesterol by multiple conversion steps. It associates with RXR and VDR in the nucleus, which stimulates transcription of VDR target genes, resulting in lower intracellular calcium levels. Less sunlight exposure results in lower 1,25-dihydroxyvitamin D3 levels and therefore higher calcium levels.
last edited

Authors

Leonie Van De Ven , Marvin Martens , Maintenance bot , Egon Willighagen , Friederike Ehrhart , and Finterly Hu

Cited In

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Organism

Homo sapiens

Communities

Diseases

Annotations

Disease Ontology: mental depression

Pathway Ontology: altered calcium/calcium-mediated signaling pathway

Participants

Label Type Compact Identifier
Inositol 1,4,5-trisphosphate Metabolite hmdb:HMDB0001498
Ketamine Metabolite hmdb:HMDB0015352
Diacylglycerol Metabolite chebi:18035
glutamate Metabolite chebi:14321
Acetylcholine Metabolite chebi:15355
PIP2 Metabolite chebi:18348
H2O2 Metabolite chebi:16240
Na+ Metabolite chebi:29101
superoxide Metabolite chebi:18421
25(OH)D3 Metabolite hmdb:HMDB0003550
Vitamin D3 Metabolite chebi:28940
K+ Metabolite chebi:29103
Ca2+ Metabolite chebi:29108
Li+ Metabolite chebi:49713
Vitamin D3 Metabolite chebi:28940
7-Dehydrocholesterol Metabolite chebi:17759
1,25-(OH)2D3 Metabolite hmdb:HMDB0000876
Ca2+ Metabolite chebi:29108
Ca2+ Metabolite chebi:29108
Ca2+ Metabolite chebi:29108
Ca2+ Metabolite chebi:29108
1,25-(OH)2D3 Metabolite hmdb:HMDB0000876
1,25-(OH)2D3 Metabolite hmdb:HMDB0000876
Na+ Metabolite chebi:29101
Ca2+ Metabolite chebi:29108
Ca2+ Metabolite chebi:29108
GGT1 GeneProduct ensembl:ENSG00000100031
RXRA GeneProduct ensembl:ENSG00000186350
ATP2B4 GeneProduct ensembl:ENSG00000058668
ATP2B3 GeneProduct ensembl:ENSG00000067842
ITPR3 GeneProduct ensembl:ENSG00000096433
G6PD GeneProduct ensembl:ENSG00000160211
KDM1B GeneProduct ensembl:ENSG00000165097
GSR GeneProduct ensembl:ENSG00000104687
CHRM1 GeneProduct ensembl:ENSG00000168539
KDM3A GeneProduct ensembl:ENSG00000115548
GCLC GeneProduct ensembl:ENSG00000001084
TPH2 GeneProduct ensembl:ENSG00000139287
GRIN2B GeneProduct ensembl:ENSG00000273079
KDM6B GeneProduct ensembl:ENSG00000132510
GRIN2D GeneProduct ensembl:ENSG00000105464
ITPR1 GeneProduct ensembl:ENSG00000150995
ATP2B2 GeneProduct ensembl:ENSG00000157087
PVALB GeneProduct ensembl:ENSG00000100362
GRIN2C GeneProduct hgnc.symbol:GRIN2C
TPH1 GeneProduct ensembl:ENSG00000129167
GRIN1 GeneProduct ensembl:ENSG00000176884
KDM1A GeneProduct ensembl:ENSG00000004487
ITPR2 GeneProduct ensembl:ENSG00000123104
ATP2B1 GeneProduct ensembl:ENSG00000070961
CYP27A1 GeneProduct ensembl:ENSG00000135929
GRM5 GeneProduct ensembl:ENSG00000168959
GRIN2A GeneProduct hgnc.symbol:GRIN2A
KCNQ2 GeneProduct ensembl:ENSG00000075043
VDR GeneProduct ensembl:ENSG00000111424
KCNQ3 GeneProduct ensembl:ENSG00000184156
SLC8A1 GeneProduct ensembl:ENSG00000183023
BCL2 GeneProduct ensembl:ENSG00000171791
CYP27B1 GeneProduct ensembl:ENSG00000111012
NFE2L2 GeneProduct ensembl:ENSG00000116044
CACNA1C GeneProduct ensembl:ENSG00000151067
SLC8A1 GeneProduct ensembl:ENSG00000183023
KCNQ2 GeneProduct ensembl:ENSG00000075043
KCNQ3 GeneProduct ensembl:ENSG00000184156
CACNA1C GeneProduct ensembl:ENSG00000151067
VDR GeneProduct ensembl:ENSG00000111424
NFE2L2 GeneProduct ensembl:ENSG00000116044
VDR GeneProduct ensembl:ENSG00000111424
RXRA GeneProduct ensembl:ENSG00000186350
GPX Protein uniprot:A0A087WT12
Calbindin Protein uniprot:P05937
Calbindin Protein uniprot:P05937

References

  1. Berridge MJ. Vitamin D and Depression: Cellular and Regulatory Mechanisms. Pharmacol Rev. 2017 Apr;69(2):80–92. PubMed Europe PMC Scholia
  2. Qin X, Wang X. Role of vitamin D receptor in the regulation of CYP3A gene expression. Acta Pharm Sin B. 2019 Nov;9(6):1087–98. PubMed Europe PMC Scholia