Pathways of nucleic acid metabolism and innate immune sensing (WP4705)

Cytosolic DNA and RNA can lead to innate immune sensing via three paths. DNA is sensed by cGAS, which activates STING. RNA is sensed by MDA5 and RIG-I, which activates MAVS. An activation of STING or MAVS lead to phosphorylation of IFR3, which triggers innate immune responses. This pathway was inspired by Chapter 14 of the 5th edition of the book of Blau (in press).
last edited


DeSl, MaintBot, Laurent, and Egonw

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Homo sapiens


Inborn Errors of Metabolism (IEM) Pathways


Pathway Ontology: altered DNA repair pathway signaling pathway in the innate immune response


Label Type Compact Identifier
DNA sensing pathway led by cGAS Pathway None
DNAreplication Pathway wikipathways:WP466
Nucleotideexcision repair Pathway wikipathways:WP1980
dsRNA Rna wikidata:Q2819370
RNase T2 Protein uniprot:O00584
SAMHD1 Protein uniprot:Q9Y3Z3
IFIH1 GeneProduct ensembl:ENSG00000115267
DDX58 GeneProduct ensembl:ENSG00000107201
IFNB GeneProduct ensembl:ENSG00000171855
dNTP pools Metabolite chebi:61560
STING Protein uniprot:Q86WV6
mRNA Rna wikidata:Q188928
DNA Rna wikidata:Q7430
Retroelement Rna wikidata:Q1473344
TMEM173 GeneProduct ensembl:ENSG00000184584
RNase H2subunit A Protein uniprot:O75792
TREX1 Protein uniprot:Q9NSU2
Adenosine Metabolite chebi:74411
OAS1 Protein uniprot:P00973
dsDNA Rna wikidata:Q55978910
RNase L Protein uniprot:Q05823
ADAR Protein uniprot:P55265
Type I signalling Pathway wikipathways:WP585
cGAS Protein uniprot:Q8N884
MAVS Protein uniprot:Q7Z434
IRF3 Protein uniprot:Q14653
cDNA Rna wikidata:Q283478
MDA5 Protein uniprot:Q9BYX4
RIG-I Protein uniprot:O95786
dN Metabolite chebi:18274
ssDNA Rna wikidata:Q10906438
ssDNA Rna wikidata:Q10906438
DNA Rna wikidata:Q7430
RNase H2subunit B Protein uniprot:Q5TBB1
RNase H2subunit C Protein uniprot:Q8TDP1
DNA Rna wikidata:Q7430
ssDNA Rna wikidata:Q10906438
ssDNA Rna wikidata:Q10906438
SAMHD1 Protein uniprot:Q9Y3Z3
dsRNA Rna wikidata:Q2819370
dsRNA Rna wikidata:Q2819370
dsRNA Rna wikidata:Q2819370
Inosine Metabolite chebi:82852
shortdsRNAfragments Rna wikidata:Q2819370
RNA sensing pathways led by MDA5 and RIG-I Pathway None
IRF3 Protein uniprot:Q14653
ISGs Protein interpro:IPR000471
Type II signalling Pathway wikipathways:WP619
rRNA Rna wikidata:Q215980


  1. Patterson JB, Samuel CE. Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase. Mol Cell Biol. 1995 Oct;15(10):5376–88. PubMed Europe PMC Scholia
  2. Deininger PL, Batzer MA. Mammalian retroelements. Genome Res. 2002 Oct;12(10):1455–65. PubMed Europe PMC Scholia
  3. Cho D-SC, Yang W, Lee JT, Shiekhattar R, Murray JM, Nishikura K. Requirement of dimerization for RNA editing activity of adenosine deaminases acting on RNA. J Biol Chem. 2003 May 9;278(19):17093–102. PubMed Europe PMC Scholia