Cholesterol metabolism with Bloch and Kandutsch-Russell pathways (WP4718)

New PW, homology converted
last edited

Authors

Denise Slenter , Eric Weitz , and Kristina Hanspers

Cited In

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Organism

Homo sapiens

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology: cholesterol biosynthetic pathway cholesterol metabolic pathway lipid signaling pathway

Participants

Label Type Compact Identifier
9Z-palmitoleic acid Metabolite pubchem.compound:445638
7alpha-hydroxycholesterol Metabolite lipidmaps:LMST01010013
Acetyl-CoA Metabolite lipidmaps:LMFA07050281
CE(16:1) Metabolite wikidata:Q412366
Acetoacetyl-CoA Metabolite lipidmaps:LMFA07050030
HMG-CoA Metabolite lipidmaps:LMFA07050116
Mevalonic acid Metabolite lipidmaps:LMFA01050352
Mevalonate-5-P Metabolite lipidmaps:LMFA01050415
Mevalonate-5-PP Metabolite lipidmaps:LMFA01050416
Isopentenyl-PP Metabolite lipidmaps:LMPR01010008
Dimethylallyl-PP Metabolite lipidmaps:LMPR01010001
Geranyl-PP Metabolite lipidmaps:LMPR0102010001
Farnesyl-PP Metabolite lipidmaps:LMPR0103010002
Squalene Metabolite lipidmaps:LMPR0106010002
Squalene-2,3-epoxide Metabolite lipidmaps:LMPR0106010010
Diepoxy-squalene Metabolite lipidmaps:LMPR0106010038
Lanosterol Metabolite lipidmaps:LMST01010017
24,25-epoxycholesterol Metabolite lipidmaps:LMST01010012
24,25-dihydrolanosterol Metabolite lipidmaps:LMST01010087
32-hydroxylanosterol Metabolite lipidmaps:LMST01010124
4,4-dimethylcholesta-5,8,24-trienol Metabolite lipidmaps:LMST01010149
4,4-dimethylcholest-8-enol Metabolite lipidmaps:LMST01010225
14-demethyl-lanosterol Metabolite lipidmaps:LMST01010176
4-alpha-methylcholest-8-enol Metabolite lipidmaps:LMST01010197
Zymosterol Metabolite lipidmaps:LMST01010066
4-alpha-methyl-cholest-8-enone Metabolite lipidmaps:LMST01010236
Zymostenol Metabolite lipidmaps:LMST01010096
Lathosterol Metabolite lipidmaps:LMST01010089
7-dehdrocholesterol Metabolite lipidmaps:LMST01010069
Cholestadienol Metabolite lipidmaps:LMST01010206
7-dehydodesmosterol Metabolite lipidmaps:LMST01010121
Desmosterol Metabolite lipidmaps:LMST01010016
Cholesterol Metabolite lipidmaps:LMST01010001
7-oxocholesterol Metabolite lipidmaps:LMST01010049
Cholestenone Metabolite lipidmaps:LMST01010015
4beta-hydroxycholesterol Metabolite lipidmaps:LMST01010014
24S-hydroxycholesterol Metabolite lipidmaps:LMST01010019
25-hydroxycholesterol Metabolite lipidmaps:LMST01010018
27-hydroxycholesterol Metabolite lipidmaps:LMST01010057
Cholesteryl esters (CE) Metabolite chebi:17002
Acyl-CoA Metabolite lipidmaps:LMFA07050000
PreSqualene Metabolite wikidata:Q27088444
CE(18:1) Metabolite wikidata:Q27116670
Oleic acid Metabolite wikidata:Q207688
4-methyl zymostenol Metabolite pubchem.compound:22212495
FF-MAS Metabolite cas:64284-64-6
SREBF1 GeneProduct ensembl:ENSG00000072310
ABCA1 GeneProduct ensembl:ENSG00000165029
CH25H GeneProduct ensembl:ENSG00000138135
HMGCR GeneProduct ensembl:ENSG00000113161
NR1H3 GeneProduct ensembl:ENSG00000025434
SOAT1 GeneProduct ensembl:ENSG00000057252
FASN GeneProduct ensembl:ENSG00000169710
DHCR7 GeneProduct ensembl:ENSG00000172893
SC5D GeneProduct ensembl:ENSG00000109929
EBP GeneProduct ensembl:ENSG00000147155
NSDHL GeneProduct ensembl:ENSG00000147383
CYP51A1 GeneProduct ensembl:ENSG00000001630
TM7SF2 GeneProduct ensembl:ENSG00000149809
MSMO1 GeneProduct ensembl:ENSG00000052802
HSD17B7 GeneProduct ensembl:ENSG00000132196
DHCR24 GeneProduct ensembl:ENSG00000116133
CYP46A1 GeneProduct ensembl:ENSG00000036530
CYP27A1 GeneProduct ensembl:ENSG00000135929
SOAT2 GeneProduct ensembl:ENSG00000167780
ACAT2 GeneProduct ensembl:ENSG00000120437
HMGCS1 GeneProduct ensembl:ENSG00000112972
HMGCS2 GeneProduct ensembl:ENSG00000134240
MVK GeneProduct ensembl:ENSG00000110921
PMVK GeneProduct ensembl:ENSG00000163344
MVD GeneProduct ensembl:ENSG00000167508
SQLE GeneProduct ensembl:ENSG00000104549
IDI1 GeneProduct ensembl:ENSG00000067064
FDFT1 GeneProduct ensembl:ENSG00000079459
GGPS1 GeneProduct ensembl:ENSG00000152904
FDPS GeneProduct ensembl:ENSG00000160752
LSS GeneProduct ensembl:ENSG00000160285
CYP51A1 GeneProduct ensembl:ENSG00000001630
DHCR7 GeneProduct ensembl:ENSG00000172893
DHCR24 GeneProduct ensembl:ENSG00000116133
NR1H2 GeneProduct ensembl:ENSG00000131408
ABCG1 GeneProduct ensembl:ENSG00000160179
MYLIP GeneProduct ensembl:ENSG00000007944
SREBF2 GeneProduct ensembl:ENSG00000198911
ACSL1 GeneProduct ensembl:ENSG00000151726
ACSL3 GeneProduct ensembl:ENSG00000123983
ACSL4 GeneProduct ensembl:ENSG00000068366
ACOT2 GeneProduct ensembl:ENSG00000119673
DHCR24 Protein ensembl:ENSG00000116133
ELOVL2 Protein ensembl:ENSG00000197977
ELOVL3 Protein ensembl:ENSG00000119915
ELOVL4 Protein ensembl:ENSG00000118402
ELOVL5 Protein ensembl:ENSG00000012660
FADS1 Protein ensembl:ENSG00000149485
FADS2 Protein ensembl:ENSG00000134824
SCD Protein ensembl:ENSG00000099194
CYP51A1 Protein ensembl:ENSG00000001630
TM7SF2 Protein ensembl:ENSG00000149809
MSMO1 Protein ensembl:ENSG00000052802
NSDHL Protein ensembl:ENSG00000147383
LBR Protein ensembl:ENSG00000143815
TM7SF2 Protein ensembl:ENSG00000149809
MSMO1 Protein ensembl:ENSG00000052802
NSDHL Protein ensembl:ENSG00000147383
LBR Protein ensembl:ENSG00000143815
HSD17B7 Protein ensembl:ENSG00000132196
MSMO1 Protein ensembl:ENSG00000052802
NSDHL Protein ensembl:ENSG00000147383
HSD17B7 Protein ensembl:ENSG00000132196
CYP51A1 Protein ensembl:ENSG00000001630
HSD17B7 Protein ensembl:ENSG00000132196

References

  1. Bae SH, Paik YK. Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. Biochem J. 1997 Sep 1;326 ( Pt 2)(Pt 2):609–16. PubMed Europe PMC Scholia
  2. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. A mouse macrophage lipidome. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
  3. Bogan RL, Debarber AE, Hennebold JD. Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells. Biol Reprod. 2012 Mar 30;86(3):89. PubMed Europe PMC Scholia
  4. Ačimovič J, Rozman D. Steroidal triterpenes of cholesterol synthesis. Molecules. 2013 Apr 4;18(4):4002–17. PubMed Europe PMC Scholia
  5. Ačimovič J, Rozman D. Steroidal triterpenes of cholesterol synthesis. Molecules. 2013 Apr 4;18(4):4002–17. PubMed Europe PMC Scholia