Cholesterol metabolism with Bloch and Kandutsch-Russell pathways (WP4718)
New PW, homology converted
Authors
Denise Slenter , Eric Weitz , and Kristina HanspersCited In
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Organism
Homo sapiensCommunities
Lipids and LIPID MAPSAnnotations
Pathway Ontology: cholesterol biosynthetic pathway cholesterol metabolic pathway lipid signaling pathway
Participants
| Label | Type | Compact Identifier |
|---|---|---|
| 9Z-palmitoleic acid | Metabolite | pubchem.compound:445638 |
| 7alpha-hydroxycholesterol | Metabolite | lipidmaps:LMST01010013 |
| Acetyl-CoA | Metabolite | lipidmaps:LMFA07050281 |
| CE(16:1) | Metabolite | wikidata:Q412366 |
| Acetoacetyl-CoA | Metabolite | lipidmaps:LMFA07050030 |
| HMG-CoA | Metabolite | lipidmaps:LMFA07050116 |
| Mevalonic acid | Metabolite | lipidmaps:LMFA01050352 |
| Mevalonate-5-P | Metabolite | lipidmaps:LMFA01050415 |
| Mevalonate-5-PP | Metabolite | lipidmaps:LMFA01050416 |
| Isopentenyl-PP | Metabolite | lipidmaps:LMPR01010008 |
| Dimethylallyl-PP | Metabolite | lipidmaps:LMPR01010001 |
| Geranyl-PP | Metabolite | lipidmaps:LMPR0102010001 |
| Farnesyl-PP | Metabolite | lipidmaps:LMPR0103010002 |
| Squalene | Metabolite | lipidmaps:LMPR0106010002 |
| Squalene-2,3-epoxide | Metabolite | lipidmaps:LMPR0106010010 |
| Diepoxy-squalene | Metabolite | lipidmaps:LMPR0106010038 |
| Lanosterol | Metabolite | lipidmaps:LMST01010017 |
| 24,25-epoxycholesterol | Metabolite | lipidmaps:LMST01010012 |
| 24,25-dihydrolanosterol | Metabolite | lipidmaps:LMST01010087 |
| 32-hydroxylanosterol | Metabolite | lipidmaps:LMST01010124 |
| 4,4-dimethylcholesta-5,8,24-trienol | Metabolite | lipidmaps:LMST01010149 |
| 4,4-dimethylcholest-8-enol | Metabolite | lipidmaps:LMST01010225 |
| 14-demethyl-lanosterol | Metabolite | lipidmaps:LMST01010176 |
| 4-alpha-methylcholest-8-enol | Metabolite | lipidmaps:LMST01010197 |
| Zymosterol | Metabolite | lipidmaps:LMST01010066 |
| 4-alpha-methyl-cholest-8-enone | Metabolite | lipidmaps:LMST01010236 |
| Zymostenol | Metabolite | lipidmaps:LMST01010096 |
| Lathosterol | Metabolite | lipidmaps:LMST01010089 |
| 7-dehdrocholesterol | Metabolite | lipidmaps:LMST01010069 |
| Cholestadienol | Metabolite | lipidmaps:LMST01010206 |
| 7-dehydodesmosterol | Metabolite | lipidmaps:LMST01010121 |
| Desmosterol | Metabolite | lipidmaps:LMST01010016 |
| Cholesterol | Metabolite | lipidmaps:LMST01010001 |
| 7-oxocholesterol | Metabolite | lipidmaps:LMST01010049 |
| Cholestenone | Metabolite | lipidmaps:LMST01010015 |
| 4beta-hydroxycholesterol | Metabolite | lipidmaps:LMST01010014 |
| 24S-hydroxycholesterol | Metabolite | lipidmaps:LMST01010019 |
| 25-hydroxycholesterol | Metabolite | lipidmaps:LMST01010018 |
| 27-hydroxycholesterol | Metabolite | lipidmaps:LMST01010057 |
| Cholesteryl esters (CE) | Metabolite | chebi:17002 |
| Acyl-CoA | Metabolite | lipidmaps:LMFA07050000 |
| PreSqualene | Metabolite | wikidata:Q27088444 |
| CE(18:1) | Metabolite | wikidata:Q27116670 |
| Oleic acid | Metabolite | wikidata:Q207688 |
| 4-methyl zymostenol | Metabolite | pubchem.compound:22212495 |
| FF-MAS | Metabolite | cas:64284-64-6 |
| SREBF1 | GeneProduct | ensembl:ENSG00000072310 |
| ABCA1 | GeneProduct | ensembl:ENSG00000165029 |
| CH25H | GeneProduct | ensembl:ENSG00000138135 |
| HMGCR | GeneProduct | ensembl:ENSG00000113161 |
| NR1H3 | GeneProduct | ensembl:ENSG00000025434 |
| SOAT1 | GeneProduct | ensembl:ENSG00000057252 |
| FASN | GeneProduct | ensembl:ENSG00000169710 |
| DHCR7 | GeneProduct | ensembl:ENSG00000172893 |
| SC5D | GeneProduct | ensembl:ENSG00000109929 |
| EBP | GeneProduct | ensembl:ENSG00000147155 |
| NSDHL | GeneProduct | ensembl:ENSG00000147383 |
| CYP51A1 | GeneProduct | ensembl:ENSG00000001630 |
| TM7SF2 | GeneProduct | ensembl:ENSG00000149809 |
| MSMO1 | GeneProduct | ensembl:ENSG00000052802 |
| HSD17B7 | GeneProduct | ensembl:ENSG00000132196 |
| DHCR24 | GeneProduct | ensembl:ENSG00000116133 |
| CYP46A1 | GeneProduct | ensembl:ENSG00000036530 |
| CYP27A1 | GeneProduct | ensembl:ENSG00000135929 |
| SOAT2 | GeneProduct | ensembl:ENSG00000167780 |
| ACAT2 | GeneProduct | ensembl:ENSG00000120437 |
| HMGCS1 | GeneProduct | ensembl:ENSG00000112972 |
| HMGCS2 | GeneProduct | ensembl:ENSG00000134240 |
| MVK | GeneProduct | ensembl:ENSG00000110921 |
| PMVK | GeneProduct | ensembl:ENSG00000163344 |
| MVD | GeneProduct | ensembl:ENSG00000167508 |
| SQLE | GeneProduct | ensembl:ENSG00000104549 |
| IDI1 | GeneProduct | ensembl:ENSG00000067064 |
| FDFT1 | GeneProduct | ensembl:ENSG00000079459 |
| GGPS1 | GeneProduct | ensembl:ENSG00000152904 |
| FDPS | GeneProduct | ensembl:ENSG00000160752 |
| LSS | GeneProduct | ensembl:ENSG00000160285 |
| CYP51A1 | GeneProduct | ensembl:ENSG00000001630 |
| DHCR7 | GeneProduct | ensembl:ENSG00000172893 |
| DHCR24 | GeneProduct | ensembl:ENSG00000116133 |
| NR1H2 | GeneProduct | ensembl:ENSG00000131408 |
| ABCG1 | GeneProduct | ensembl:ENSG00000160179 |
| MYLIP | GeneProduct | ensembl:ENSG00000007944 |
| SREBF2 | GeneProduct | ensembl:ENSG00000198911 |
| ACSL1 | GeneProduct | ensembl:ENSG00000151726 |
| ACSL3 | GeneProduct | ensembl:ENSG00000123983 |
| ACSL4 | GeneProduct | ensembl:ENSG00000068366 |
| ACOT2 | GeneProduct | ensembl:ENSG00000119673 |
| DHCR24 | Protein | ensembl:ENSG00000116133 |
| ELOVL2 | Protein | ensembl:ENSG00000197977 |
| ELOVL3 | Protein | ensembl:ENSG00000119915 |
| ELOVL4 | Protein | ensembl:ENSG00000118402 |
| ELOVL5 | Protein | ensembl:ENSG00000012660 |
| FADS1 | Protein | ensembl:ENSG00000149485 |
| FADS2 | Protein | ensembl:ENSG00000134824 |
| SCD | Protein | ensembl:ENSG00000099194 |
| CYP51A1 | Protein | ensembl:ENSG00000001630 |
| TM7SF2 | Protein | ensembl:ENSG00000149809 |
| MSMO1 | Protein | ensembl:ENSG00000052802 |
| NSDHL | Protein | ensembl:ENSG00000147383 |
| LBR | Protein | ensembl:ENSG00000143815 |
| TM7SF2 | Protein | ensembl:ENSG00000149809 |
| MSMO1 | Protein | ensembl:ENSG00000052802 |
| NSDHL | Protein | ensembl:ENSG00000147383 |
| LBR | Protein | ensembl:ENSG00000143815 |
| HSD17B7 | Protein | ensembl:ENSG00000132196 |
| MSMO1 | Protein | ensembl:ENSG00000052802 |
| NSDHL | Protein | ensembl:ENSG00000147383 |
| HSD17B7 | Protein | ensembl:ENSG00000132196 |
| CYP51A1 | Protein | ensembl:ENSG00000001630 |
| HSD17B7 | Protein | ensembl:ENSG00000132196 |
References
- Bae SH, Paik YK. Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. Biochem J. 1997 Sep 1;326 ( Pt 2)(Pt 2):609–16. PubMed Europe PMC Scholia
- Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. A mouse macrophage lipidome. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
- Bogan RL, Debarber AE, Hennebold JD. Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells. Biol Reprod. 2012 Mar 30;86(3):89. PubMed Europe PMC Scholia
- Ačimovič J, Rozman D. Steroidal triterpenes of cholesterol synthesis. Molecules. 2013 Apr 4;18(4):4002–17. PubMed Europe PMC Scholia
- Ačimovič J, Rozman D. Steroidal triterpenes of cholesterol synthesis. Molecules. 2013 Apr 4;18(4):4002–17. PubMed Europe PMC Scholia