Eicosanoid metabolism via cyclooxygenases (COX) (WP4719)

New PW, homology converted
last edited

Authors

Denise Slenter , Egon Willighagen , Eric Weitz , and Conroy lipids

Cited In

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Organism

Homo sapiens

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology: arachidonic acid metabolic pathway eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma eicosanoid signaling pathway eicosanoid biosynthetic pathway eicosanoid biosynthetic pathway inflammatory response pathway eicosanoid metabolic pathway cyclooxygenase mediated pathway of arachidonic acid metabolism

Participants

Label Type Compact Identifier
Glycerophospholipids Metabolite chebi:37739
Arachidonic acid Metabolite lipidmaps:LMFA01030001
PGG2 Metabolite lipidmaps:LMFA03010009
PGH2 Metabolite lipidmaps:LMFA03010010
PGE2 Metabolite lipidmaps:LMFA03010003
PGF2a Metabolite lipidmaps:LMFA03010002
PGD2 Metabolite lipidmaps:LMFA03010004
PGJ2 Metabolite lipidmaps:LMFA03010019
delta-12-PGJ2 Metabolite lipidmaps:LMFA03010020
15-deoxy-delta-12-PGD2 Metabolite lipidmaps:LMFA03010021
11-HETE Metabolite lipidmaps:LMFA03060085
PGI2 Metabolite lipidmaps:LMFA03010087
6-keto-PGF1alpha Metabolite lipidmaps:LMFA03010001
6-keto-PGE1 Metabolite lipidmaps:LMFA03010012
PGA2 Metabolite lipidmaps:LMFA03010035
PGB2 Metabolite lipidmaps:LMFA03010018
15-deoxy-PGA2 Metabolite lipidmaps:LMFA03010172
Dinor-PGE2 Metabolite lipidmaps:LMFA03010210
Tetranor-PGE2 Metabolite lipidmaps:LMFA03010211
Dinor-PGF2a Metabolite lipidmaps:LMFA03010212
Tetranor-PGF2a Metabolite lipidmaps:LMFA03010213
Dinor-PGD2 Metabolite lipidmaps:LMFA03010214
Tetranor-PGD2 Metabolite lipidmaps:LMFA03010215
20-hydroxy-PGE2 Metabolite lipidmaps:LMFA03010014
20-hydroxy-PGF2a Metabolite lipidmaps:LMFA03010029
20-hydroxy-PGD2 Metabolite lipidmaps:LMFA03010216
15-deoxy-delta-12-PGJ2 Metabolite lipidmaps:LMFA03010021
TXA2 Metabolite lipidmaps:LMFA03030001
TXB2 Metabolite lipidmaps:LMFA03030002
11-dehydro-TXB2 Metabolite lipidmaps:LMFA03030004
12S-HHTrE Metabolite lipidmaps:LMFA03050002
15-keto-PGE2 Metabolite lipidmaps:LMFA03010030
15-keto-PGF2a Metabolite lipidmaps:LMFA03010026
15-keto-PGD2 Metabolite lipidmaps:LMFA03010206
13,14-dihydro-15-keto-PGE2 Metabolite lipidmaps:LMFA03010031
13,14-dihydro-15-keto-PGF2a Metabolite lipidmaps:LMFA03010027
13,14-dihydro-15-keto-PGD2 Metabolite lipidmaps:LMFA03010022
15(S)-HETE Metabolite lipidmaps:LMFA03060001
15(R)-HETE Metabolite lipidmaps:LMFA03060030
PTGIS GeneProduct ensembl:ENSG00000124212
TBXAS1 GeneProduct ensembl:ENSG00000059377
HPGD GeneProduct ensembl:ENSG00000164120
HPGD GeneProduct ensembl:ENSG00000164120
PLA2G5 Protein ensembl:ENSG00000127472
PPARD Protein ensembl:ENSG00000112033
PLA2G6 Protein ensembl:ENSG00000184381
PLA2G4A Protein ensembl:ENSG00000116711
PLA2G4B Protein ensembl:ENSG00000243708
PTGS1 Protein ensembl:ENSG00000095303
PTGS2 Protein ensembl:ENSG00000073756
PTGES Protein ensembl:ENSG00000148344
PTGDS Protein ensembl:ENSG00000107317
AKR1B1 Protein ensembl:ENSG00000085662
PTGR1 Protein ensembl:ENSG00000106853
PTGR2 Protein ensembl:ENSG00000140043
CYP4A11 Protein ensembl:ENSG00000187048
CYP4A22 Protein ensembl:ENSG00000162365
CYP4A22 Protein ensembl:ENSG00000162365
CYP4F12 Protein ensembl:ENSG00000186204
CYP4F2 Protein ensembl:ENSG00000186115
ACOX1 Protein ensembl:ENSG00000161533
ACOX2 Protein ensembl:ENSG00000168306
ACOX3 Protein ensembl:ENSG00000087008
ACAA1 Protein ensembl:ENSG00000060971
EHHADH Protein ensembl:ENSG00000113790
PTGIR Protein ensembl:ENSG00000160013
PPAR gamma Protein uniprot:P37231
PRXL2B Protein ensembl:ENSG00000157870
PTGFR Protein ensembl:ENSG00000122420
PPAR gamma Protein uniprot:P37231
PTGDR Protein ensembl:ENSG00000168229
PTGDR2 Protein ensembl:ENSG00000183134
TBXA2R Protein ensembl:ENSG00000006638
PTGS1 Protein ensembl:ENSG00000095303
PTGS1 Protein ensembl:ENSG00000095303

References

  1. Moreno JJ. New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development. Biochem Pharmacol. 2009 Jan 1;77(1):1–10. PubMed Europe PMC Scholia
  2. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. A mouse macrophage lipidome. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
  3. Dennis EA, Norris PC. Eicosanoid storm in infection and inflammation. Nat Rev Immunol. 2015 Aug;15(8):511–23. PubMed Europe PMC Scholia