Eicosanoid metabolism via cytochrome P450 monooxygenases pathway (WP4720)

New PW, homology converted
last edited


Denise Slenter , Eric Weitz , and Egon Willighagen

Cited In

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Homo sapiens


Lipids and LIPID MAPS


Pathway Ontology: eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolism eicosanoid metabolic pathway


Label Type Compact Identifier
Arachidonic acid Metabolite lipidmaps:LMFA01030001
16-HETE Metabolite lipidmaps:LMFA03090010
17-HETE Metabolite lipidmaps:LMFA03060091
18-HETE Metabolite lipidmaps:LMFA03060092
19-HETE Metabolite lipidmaps:LMFA03060106
20-HETE Metabolite lipidmaps:LMFA03060009
5,6-EpETrE Metabolite lipidmaps:LMFA03080002
8,9-EpETrE Metabolite lipidmaps:LMFA03080003
11,12-EpETrE Metabolite lipidmaps:LMFA03090010
14,15-EpETrE Metabolite lipidmaps:LMFA03080005
5,6-DiHETrE Metabolite lipidmaps:LMFA03050004
8,9-DiHETrE Metabolite lipidmaps:LMFA03050006
11,12-DiHETrE Metabolite lipidmaps:LMFA03050008
14,15-DiHETrE Metabolite lipidmaps:LMFA03050010
EPHX2 GeneProduct ensembl:ENSG00000120915
CYP4A11 GeneProduct ensembl:ENSG00000187048
CYP4A22 GeneProduct ensembl:ENSG00000162365
CYP4A22 GeneProduct ensembl:ENSG00000162365
CYP4F12 GeneProduct ensembl:ENSG00000186204
CYP4F2 GeneProduct ensembl:ENSG00000186115
PPAR gamma Protein uniprot:P37231
CYP2C8 Protein ensembl:ENSG00000138115
CYP2C8 Protein ensembl:ENSG00000138115
CYP2C8 Protein ensembl:ENSG00000138115
CYP2C18 Protein ensembl:ENSG00000108242
PPARA Protein ensembl:ENSG00000186951


  1. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. A mouse macrophage lipidome. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
  2. Dennis EA, Norris PC. Eicosanoid storm in infection and inflammation. Nat Rev Immunol. 2015 Aug;15(8):511–23. PubMed Europe PMC Scholia