New PW, homology converted

Authors

Denise Slenter , Eric Weitz , and Egon Willighagen

Cited In

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Organism

Homo sapiens

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology: eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolism eicosanoid metabolic pathway

Participants

Label	Type	Compact Identifier
Arachidonic acid	Metabolite	lipidmaps:LMFA01030001
16-HETE	Metabolite	lipidmaps:LMFA03090010
17-HETE	Metabolite	lipidmaps:LMFA03060091
18-HETE	Metabolite	lipidmaps:LMFA03060092
19-HETE	Metabolite	lipidmaps:LMFA03060106
20-HETE	Metabolite	lipidmaps:LMFA03060009
5,6-EpETrE	Metabolite	lipidmaps:LMFA03080002
8,9-EpETrE	Metabolite	lipidmaps:LMFA03080003
11,12-EpETrE	Metabolite	lipidmaps:LMFA03090010
14,15-EpETrE	Metabolite	lipidmaps:LMFA03080005
5,6-DiHETrE	Metabolite	lipidmaps:LMFA03050004
8,9-DiHETrE	Metabolite	lipidmaps:LMFA03050006
11,12-DiHETrE	Metabolite	lipidmaps:LMFA03050008
14,15-DiHETrE	Metabolite	lipidmaps:LMFA03050010
EPHX2	GeneProduct	ensembl:ENSG00000120915
CYP4A11	GeneProduct	ensembl:ENSG00000187048
CYP4A22	GeneProduct	ensembl:ENSG00000162365
CYP4A22	GeneProduct	ensembl:ENSG00000162365
CYP4F12	GeneProduct	ensembl:ENSG00000186204
CYP4F2	GeneProduct	ensembl:ENSG00000186115
PPAR gamma	Protein	uniprot:P37231
CYP2C8	Protein	ensembl:ENSG00000138115
CYP2C8	Protein	ensembl:ENSG00000138115
CYP2C8	Protein	ensembl:ENSG00000138115
CYP2C18	Protein	ensembl:ENSG00000108242
PPARA	Protein	ensembl:ENSG00000186951

References

1. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. A mouse macrophage lipidome. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
2. Dennis EA, Norris PC. Eicosanoid storm in infection and inflammation. Nat Rev Immunol. 2015 Aug;15(8):511–23. PubMed Europe PMC Scholia