Eicosanoid metabolism via lipooxygenases (LOX) (WP4721)

New PW, homology converted
last edited

Authors

Denise Slenter , Eric Weitz , and Egon Willighagen

Cited In

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Organism

Homo sapiens

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology: lipoxygenase mediated pathway of arachidonic acid metabolism eicosanoid metabolic pathway

Participants

Label Type Compact Identifier
12(R)-HpETE Metabolite lipidmaps:LMFA03060070
LTA4 Metabolite lipidmaps:LMFA03020023
Arachidonic acid Metabolite lipidmaps:LMFA01030001
15-HpETE Metabolite lipidmaps:LMFA03060014
15-HETE Metabolite lipidmaps:LMFA03060087
8-HpETE Metabolite lipidmaps:LMFA03060073
8-HETE Metabolite lipidmaps:LMFA03060086
15-oxoETE Metabolite lipidmaps:LMFA03060051
LXA4 Metabolite lipidmaps:LMFA03040001
12-HpETE Metabolite lipidmaps:LMFA03060013
12-HETE Metabolite lipidmaps:LMFA03060088
12-oxoETE Metabolite lipidmaps:LMFA03060019
HXB3 Metabolite lipidmaps:LMFA03090003
HXA3 Metabolite lipidmaps:LMFA03090005
TXA3 Metabolite lipidmaps:LMFA03030005
TXB3 Metabolite lipidmaps:LMFA03030006
LXB4 Metabolite lipidmaps:LMFA03040002
LTB4 Metabolite lipidmaps:LMFA03020001
12-epi-LTB4 Metabolite lipidmaps:LMFA03020015
6-trans-12-epi-delta-LTB4 Metabolite lipidmaps:LMFA03020014
6-trans-delta-LTB4 Metabolite lipidmaps:LMFA03020013
LTC4 Metabolite lipidmaps:LMFA03020003
LTD4 Metabolite lipidmaps:LMFA03020006
LTE4 Metabolite lipidmaps:LMFA03020002
EXC4 Metabolite lipidmaps:LMFA03020031
EXD4 Metabolite lipidmaps:LMFA03020032
EXE4 Metabolite lipidmaps:LMFA03020033
20-hydroxy-LTB4 Metabolite lipidmaps:LMFA03020018
20-carboxy-LTB4 Metabolite lipidmaps:LMFA03020016
18-carboxy-dinor-LTB4 Metabolite lipidmaps:LMFA03020056
11-trans-LTC4 Metabolite lipidmaps:LMFA03020020
11-trans-LTD4 Metabolite lipidmaps:LMFA03020021
11-trans-LTE4 Metabolite lipidmaps:LMFA03020022
5-HpETE Metabolite lipidmaps:LMFA03060108
5-HETE Metabolite lipidmaps:LMFA03060084
5-oxoETE Metabolite lipidmaps:LMFA03060011
15-oxo-LXA4 Metabolite lipidmaps:LMFA03040009
13,14-dihydro-15-oxo-LXA4 Metabolite lipidmaps:LMFA03040008
12-oxo-LTB4 Metabolite lipidmaps:LMFA03020024
LXB4 Metabolite lipidmaps:LMFA03040002
15-HETE Metabolite lipidmaps:LMFA03060087
5,12-diHETE Metabolite lipidmaps:LMFA03060052
CYP4A11 GeneProduct ensembl:ENSG00000187048
LTA4H GeneProduct ensembl:ENSG00000111144
ALOX5 GeneProduct ensembl:ENSG00000012779
ALOX15 GeneProduct ensembl:ENSG00000161905
HPGD GeneProduct ensembl:ENSG00000164120
ALOX12 GeneProduct ensembl:ENSG00000108839
LTC4S GeneProduct ensembl:ENSG00000213316
CYP4A22 GeneProduct ensembl:ENSG00000162365
CYP4A22 GeneProduct ensembl:ENSG00000162365
CYP4F12 GeneProduct ensembl:ENSG00000186204
CYP4F2 GeneProduct ensembl:ENSG00000186115
ACOX1 GeneProduct ensembl:ENSG00000161533
ACOX2 GeneProduct ensembl:ENSG00000168306
ACOX3 GeneProduct ensembl:ENSG00000087008
EHHADH GeneProduct ensembl:ENSG00000113790
ACAA1 GeneProduct ensembl:ENSG00000060971
GGT5 GeneProduct ensembl:ENSG00000099998
DPEP1 GeneProduct ensembl:ENSG00000015413
PTGR1 GeneProduct ensembl:ENSG00000106853
PTGR2 GeneProduct ensembl:ENSG00000140043
ALOX12 GeneProduct ensembl:ENSG00000108839
ALOX5 GeneProduct ensembl:ENSG00000012779
PTGR1 GeneProduct ensembl:ENSG00000106853
PTGR2 GeneProduct ensembl:ENSG00000140043
HPGD GeneProduct ensembl:ENSG00000164120
ALOX5 GeneProduct ensembl:ENSG00000012779
LTA4H GeneProduct ensembl:ENSG00000111144
LTC4S GeneProduct ensembl:ENSG00000213316
LTB4R Protein ensembl:ENSG00000213903
ALOX15B Protein ensembl:ENSG00000179593
LTB4R2 Protein ensembl:ENSG00000213906
PPARA Protein ensembl:ENSG00000186951
CYSLTR1 Protein ensembl:ENSG00000173198
CYSLTR2 Protein ensembl:ENSG00000152207
FPR2 Protein ensembl:ENSG00000171049
ALOX15B Protein ensembl:ENSG00000179593
ALOX15 Protein ensembl:ENSG00000161905
ALOX15 Protein ensembl:ENSG00000161905
ALOX12 Protein ensembl:ENSG00000108839
ALOX12 Protein ensembl:ENSG00000108839
PPARA Protein ensembl:ENSG00000186951
PPARD Protein ensembl:ENSG00000112033
TRPA1 Protein ensembl:ENSG00000104321
TRPV1 Protein ensembl:ENSG00000196689
ALOX5 Protein ensembl:ENSG00000012779
ALOX5 Protein ensembl:ENSG00000012779
ALOX15 Protein ensembl:ENSG00000161905
ALOX12 Protein ensembl:ENSG00000108839
ALOX15 Protein ensembl:ENSG00000161905
ALOX15B Protein ensembl:ENSG00000179593
ALOX15 Protein ensembl:ENSG00000161905
ALOX12 Protein ensembl:ENSG00000108839
ALOX12 Protein ensembl:ENSG00000108839

References

  1. Moreno JJ. New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development. Biochem Pharmacol. 2009 Jan 1;77(1):1–10. PubMed Europe PMC Scholia
  2. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. A mouse macrophage lipidome. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
  3. Dennis EA, Norris PC. Eicosanoid storm in infection and inflammation. Nat Rev Immunol. 2015 Aug;15(8):511–23. PubMed Europe PMC Scholia