Sphingolipid metabolism overview (WP4725)

New PW, homology converted
last edited

Authors

DeSl and Eweitz

Cited In

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Organism

Homo sapiens

Communities

Inborn Errors of Metabolism (IEM) Pathways Lipids and LIPID MAPS

Annotations

Pathway Ontology: sphingolipid biosynthetic pathway sphingolipid metabolic pathway sphingomyelin metabolic pathway

Participants

Label Type Compact Identifier
ATP Metabolite chebi:30616
3-keto-sphinganine Metabolite lipidmaps:LMSP01020002
Ppap2a Protein None
CERK Protein ensembl:ENSG00000100422
SGPP1 Protein ensembl:ENSG00000126821
ASAH1 Protein ensembl:ENSG00000104763
Palmitoyl-CoA Metabolite lipidmaps:LMFA07050360
SGMS1 Protein ensembl:ENSG00000198964
SPHK2 Protein ensembl:ENSG00000063176
SGPL1 Protein ensembl:ENSG00000166224
UGCG Protein ensembl:ENSG00000148154
Serine Metabolite pubchem.compound:5951
Hexadecanal Metabolite lipidmaps:LMFA06000088
SPTLC1 Protein ensembl:ENSG00000090054
SPHK1 Protein ensembl:ENSG00000176170
DEGS1 Protein ensembl:ENSG00000143753
KDSR Protein ensembl:ENSG00000119537
SPTLC2 Protein ensembl:ENSG00000100596
Ethanolamine-phosphate Metabolite pubchem.compound:1015
H2O Metabolite chebi:15377
Sphingosine Metabolite lipidmaps:LMSP01010001
Sphinganine Metabolite lipidmaps:LMSP01020001
Sphinganine-1-phosphate Metabolite lipidmaps:LMSP01050002
DH-Ceramide Metabolite lipidmaps:LMSP02020000
CERS4 Protein ensembl:ENSG00000090661
CERS4 Protein ensembl:ENSG00000090661
CERS6 Protein ensembl:ENSG00000172292
Ceramide Metabolite lipidmaps:LMSP02010000
Cer-1-P Metabolite lipidmaps:LMSP02050000
DH-Cer-1-P Metabolite lipidmaps:LMSP020500A0
SM Metabolite lipidmaps:LMSP0301
Glc-Cer Metabolite lipidmaps:LMSP0501AA00
DH-SM Metabolite lipidmaps:LMSP030100A0
DH-Glc-Cer Metabolite LIPID MAPS
Gal-Cer Metabolite lipidmaps:LMSP0501AC00
DH-Gal-Cer Metabolite LIPID MAPS
SMPD1 Protein ensembl:ENSG00000166311
DEGS2 Protein ensembl:ENSG00000168350
SGMS2 Protein ensembl:ENSG00000164023
Sphingosine-1-phosphate Metabolite lipidmaps:LMSP01050001
1-Hexadecenal Metabolite lipidmaps:LMFA06000088
PLPP3 Protein ensembl:ENSG00000162407
Ppap2c Protein None
CoA(16:0) Metabolite lipidmaps:LMFA07050360
UGT8 Protein ensembl:ENSG00000174607
CoA(18:0) Metabolite chebi:15541
CoA(20:0) Metabolite chebi:15527
CoA(22:0) Metabolite cas:24330-89-0
CoA(24:0) Metabolite cas:24305-30-4
CoA(24:1) Metabolite cas:88362-35-0
CoA(16:0) Metabolite lipidmaps:LMFA07050360
CoA(18:0) Metabolite chebi:15541
CoA(20:0) Metabolite chebi:15527
CoA(22:0) Metabolite cas:24330-89-0
CoA(24:0) Metabolite cas:24305-30-4
CoA(24:1) Metabolite cas:88362-35-0
DH-Ceramide Metabolite lipidmaps:LMSP02020000
DH-Ceramide Metabolite lipidmaps:LMSP02020000
DH-Ceramide Metabolite lipidmaps:LMSP02020000
DH-Ceramide Metabolite lipidmaps:LMSP02020000
CERS1 Protein ensembl:ENSG00000223802
CERS4 Protein ensembl:ENSG00000090661
CERS2 Protein ensembl:ENSG00000143418
CoA(26:0) Metabolite cas:99313-57-2
CoA(26:1) Metabolite None
DH-Ceramide Metabolite lipidmaps:LMSP02020000
CERS3 Protein ensembl:ENSG00000154227
CoA(26:0) Metabolite cas:99313-57-2
CoA(26:1) Metabolite None
ADP Metabolite chebi:456216
SGPP2 Protein ensembl:ENSG00000163082

References

  1. Le Stunff H, Peterson C, Thornton R, Milstien S, Mandala SM, Spiegel S. Characterization of murine sphingosine-1-phosphate phosphohydrolase. J Biol Chem. 2002 Mar 15;277(11):8920–7. PubMed Europe PMC Scholia
  2. Merrill AH Jr. De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. J Biol Chem. 2002 Jul 19;277(29):25843–6. PubMed Europe PMC Scholia
  3. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. A mouse macrophage lipidome. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia