HIPK2 in kidney fibrosis (WP4751)

This pathway shows the activation of multiple signaling pathways involved in kidney fibrosis, starting from an insult like HIV infection or oxidative stress, through the suppression of SIAH1 and increased expression of HIPK2. This pathway was adapted from Figure 6i of [https://pubmed.ncbi.nlm.nih.gov/22406746/ Jin et. al.]
last edited


Agustin Gonzalez-Vicente , Kristina Hanspers , and Egon Willighagen

Cited In

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Homo sapiens




Disease Ontology: renal fibrosis

Pathway Ontology: kidney disease pathway


Label Type Compact Identifier
SIAH1 GeneProduct ncbigene:6477
HIPK2 GeneProduct ncbigene:28996


  1. Jin Y, Ratnam K, Chuang PY, Fan Y, Zhong Y, Dai Y, et al. A systems approach identifies HIPK2 as a key regulator of kidney fibrosis. Nat Med. 2012 Mar 11;18(4):580–8. PubMed Europe PMC Scholia