This pathway shows the activation of multiple signaling pathways involved in kidney fibrosis, starting from an insult like HIV infection or oxidative stress, through the suppression of SIAH1 and increased expression of HIPK2. This pathway was adapted from Figure 6i of [https://pubmed.ncbi.nlm.nih.gov/22406746/ Jin et. al.]

Authors

Agustin Gonzalez-Vicente , Kristina Hanspers , and Egon Willighagen

Cited In

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Organism

Homo sapiens

Communities

Diseases

Annotations

Disease Ontology: renal fibrosis

Pathway Ontology: kidney disease pathway

Participants

Label	Type	Compact Identifier
SIAH1	GeneProduct	ncbigene:6477
HIPK2	GeneProduct	ncbigene:28996

References

1. Jin Y, Ratnam K, Chuang PY, Fan Y, Zhong Y, Dai Y, et al. A systems approach identifies HIPK2 as a key regulator of kidney fibrosis. Nat Med. 2012 Mar 11;18(4):580–8. PubMed Europe PMC Scholia