Base excision repair (WP4752)

Base excision repair is a cellular mechanism that repairs damaged DNA throughout the cell cycle. It is primarily responsible for removing small, non-helix-distorting base lesions from the genome. Base excision repair is important for removing damaged bases that could otherwise cause mutations by mispairing, or could lead to breaks in DNA during replication. BER is initiated by DNA glycosylases, which recognize and remove specific damaged or inappropriate bases, forming AP sites. These are then cleaved by an AP endonuclease. The resulting single-strand break can then be processed by either short-patch (where a single nucleotide is replaced) or long-patch BER (where 2-10 new nucleotides are synthesized). The choice between short- and long-patch repair is currently under investigation. Various factors are thought to influence this decision, including the type of lesion, the cell cycle stage, and whether the cell is terminally differentiated or actively dividing. Some lesions, such as oxidized or reduced AP sites, are resistant to pol β lyase activity and therefore must be processed by long-patch BER. This pathway is based on information from [http://repairtoire.genesilico.pl/Pathway/4/ REPAIRtoire], [https://en.wikipedia.org/wiki/Base_excision_repair Wikipedia] and [https://www.genome.jp/dbget-bin/www_bget?map03410 KEGG]. The description was adapted from REPAIRtoire, layout is based on KEGG.
last edited

Authors

Khanspers, Eweitz, and Finterly

Cited In

Organism

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology: DNA repair pathway base excision repair pathway

Participants

Label Type Compact Identifier
PARP1 GeneProduct ensembl:ENSG00000143799
APEX1 GeneProduct ensembl:ENSG00000100823
PNKP GeneProduct ensembl:ENSG00000039650
OGG1 GeneProduct ensembl:ENSG00000114026
NTHL1 GeneProduct ensembl:ENSG00000065057
NTHL1 GeneProduct ensembl:ENSG00000065057
NEIL2 GeneProduct ensembl:ENSG00000154328
NEIL3 GeneProduct ensembl:ENSG00000109674
APEX2 GeneProduct ensembl:ENSG00000169188
XRCC1 GeneProduct ensembl:ENSG00000073050
LIG3 GeneProduct ensembl:ENSG00000005156
LIG1 GeneProduct ensembl:ENSG00000105486
POLB GeneProduct ensembl:ENSG00000070501
XRCC1 GeneProduct ensembl:ENSG00000073050
UNG GeneProduct ensembl:ENSG00000076248
SMUG1 GeneProduct ensembl:ENSG00000123415
MUTYH GeneProduct ensembl:ENSG00000132781
MPG GeneProduct ensembl:ENSG00000103152
MBD4 GeneProduct ensembl:ENSG00000129071
TDG GeneProduct ensembl:ENSG00000139372
APEX1 GeneProduct ensembl:ENSG00000100823
APEX2 GeneProduct ensembl:ENSG00000169188
POLB GeneProduct ensembl:ENSG00000070501
POLL GeneProduct ensembl:ENSG00000166169
HMGB1 GeneProduct ensembl:ENSG00000189403
POLB GeneProduct ensembl:ENSG00000070501
POLE GeneProduct ensembl:ENSG00000177084
POLD1 GeneProduct ensembl:ENSG00000062822
POLD2 GeneProduct ensembl:ENSG00000106628
POLE2 GeneProduct ensembl:ENSG00000100479
POLE3 GeneProduct ensembl:ENSG00000148229
POLE4 GeneProduct ensembl:ENSG00000115350
POLD3 GeneProduct ensembl:ENSG00000077514
POLD4 GeneProduct ensembl:ENSG00000175482
PCNA GeneProduct ensembl:ENSG00000132646
PCNA GeneProduct ensembl:ENSG00000132646
FEN1 GeneProduct ensembl:ENSG00000168496
PCNA GeneProduct ensembl:ENSG00000132646
PARP2 GeneProduct ensembl:ENSG00000129484
PARP1 GeneProduct ensembl:ENSG00000143799
PARP2 GeneProduct ensembl:ENSG00000129484

References