Purine metabolism (WP4792)

Overview of purine metabolism; metabolic markers are highlighted in red, with graphical arrows indicating if a marker is present in higher or lower concentrations compared to normal (healthy) levels. This pathway was inspired by Chapter 13, edition 5 of the book of Blau (in press). The full version of this PW including disorders, based on ed. 4, can be found [https://www.wikipathways.org/index.php/Pathway:WP4224 here]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP4792 CPTAC Assay Portal]
last edited


DeSl, Mkutmon, L Dupuis, and Finterly

Cited In

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Homo sapiens


Inborn Errors of Metabolism (IEM) Pathways Rare Diseases


Pathway Ontology: purine metabolic pathway


Label Type Compact Identifier
PRPP Metabolite chebi:17111
ATP Metabolite chebi:30616
XMP Metabolite chebi:57464
SAICARP Metabolite chebi:58443
AICA-riboside Metabolite chebi:28498
APRT Protein uniprot:P07741
AMP Metabolite chebi:456215
Xanthosine Metabolite chebi:18107
2-Deoxyadenosine Metabolite ChEBI
Inosine Metabolite ChEBI
GDP Metabolite ChEBI
ATIC Protein Uniprot-TrEMBL
Ribose-5-P Metabolite ChEBI
SAICA-riboside Metabolite ChEBI
ADA Protein Uniprot-TrEMBL
dGDP Metabolite ChEBI
Succinyladenosine Metabolite ChEBI
ADSL Protein Uniprot-TrEMBL
dATP Metabolite ChEBI
AICARP Metabolite ChEBI
2,8-Dihydroxyadenine Metabolite Wikidata
dADP Metabolite ChEBI
Adenosine Metabolite ChEBI
dAMP Metabolite ChEBI
ITP Metabolite ChEBI
PRPS1 Protein Uniprot-TrEMBL
ADSS Protein Uniprot-TrEMBL
Hypoxanthine Metabolite ChEBI
Guanosine Metabolite ChEBI
ADSL Protein Uniprot-TrEMBL
PRPPs Protein Enzyme Nomenclature
IMPDH1 Protein Uniprot-TrEMBL
HPRT1 Protein Uniprot-TrEMBL
S-AMP Metabolite ChEBI
Xanthine Metabolite ChEBI
ADP Metabolite ChEBI
DGUOK Protein Uniprot-TrEMBL
GTP Metabolite ChEBI
dGTP Metabolite ChEBI
AMPD1 Protein Uniprot-TrEMBL
Urate Metabolite ChEBI
PNP Protein Uniprot-TrEMBL
ITPA Protein Uniprot-TrEMBL
Adenine Metabolite ChEBI
Guanine Metabolite ChEBI
RR Protein Enzyme Nomenclature
dGMP Metabolite ChEBI
FAICARP Metabolite ChEBI
2-Deoxyguanosine Metabolite ChEBI
GMP Metabolite ChEBI
2-deoxyinosine Metabolite chebi:28997
IMP Metabolite chebi:58053
PNP Protein uniprot:P00491
PNP Protein uniprot:P00491
XO Protein uniprot:P47989
RR Protein eccode:
ATIC Protein uniprot:P31939
ADA Protein uniprot:P00813
PNP Protein uniprot:P00491
HPRT1 Protein uniprot:P00492
XO Protein uniprot:P47989
PNP Protein uniprot:P00491
XO Protein uniprot:P47989
PNP Protein uniprot:P00491