Insulin signaling (WP481)

Insulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose from the blood. Other branches of the signal cascade lead to cell growth and differentiation. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP481 CPTAC Assay Portal]
last edited

Authors

M.Patti, MaintBot, Thomas, Andra, Khanspers, Mkutmon, MartijnVanIersel, Eduati, AlexanderPico, Ycc86829, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: insulin signaling pathway

Participants

Label Type Compact Identifier
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References

  1. Quon MJ, Campfield LA. A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation. J Theor Biol. 1991 May 7;150(1):93–107. PubMed Europe PMC Scholia
  2. Bevan P. Insulin signalling. J Cell Sci. 2001 Apr;114(Pt 8):1429–30. PubMed Europe PMC Scholia
  3. Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001 Dec 13;414(6865):799–806. PubMed Europe PMC Scholia