Apoptosis modulation by HSP70 (WP487)

This pathway summarizes the various ways by which HSP70 proteins can inhibit apoptosis.
last edited

Authors

I.Reyes, MaintBot, Siddarth, Christine Chichester, Mkutmon, Khanspers, Egonw, and Eweitz

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: apoptotic cell death pathway

Participants

Label Type Compact Identifier
Apaf1 GeneProduct ncbigene:78963
Hspa1a GeneProduct ncbigene:24472
Map3k1 GeneProduct ncbigene:116667
NF-kB pathway Pathway None
Apoptosis Pathway wikipathways:WP1290
Faslg GeneProduct ensembl:ENSRNOG00000002978
Tnfrsf1a GeneProduct ncbigene:25625
Hspa1a GeneProduct ncbigene:24472
Hspa1a GeneProduct ncbigene:24472
Casp3 GeneProduct ncbigene:25402
Casp8 GeneProduct ncbigene:64044
Cycs GeneProduct ncbigene:25309
Bid GeneProduct ncbigene:64625
Nfkb1 GeneProduct ncbigene:81736
Fadd GeneProduct ncbigene:266610
Casp9 GeneProduct ncbigene:58918
Mapk10 GeneProduct ncbigene:25272
Pdcd8 GeneProduct ncbigene:83533
Fadd GeneProduct ncbigene:266610
Casp8 GeneProduct ncbigene:64044
Ripk1 GeneProduct ncbigene:306886
Casp2 GeneProduct ncbigene:64314
Casp7 GeneProduct ncbigene:64026
Casp6 GeneProduct ncbigene:83584
Fas GeneProduct ensembl:ENSRNOG00000019142
Cycs GeneProduct ncbigene:25309

References

  1. Jäättelä M, Wissing D, Kokholm K, Kallunki T, Egeblad M. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J. 1998 Nov 2;17(21):6124–34. PubMed Europe PMC Scholia
  2. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY. Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging. FEBS Lett. 1998 Oct 30;438(1–2):1–4. PubMed Europe PMC Scholia
  3. Schett G, Steiner CW, Gröger M, Winkler S, Graninger W, Smolen J, et al. Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70. FASEB J. 1999 May;13(8):833–42. PubMed Europe PMC Scholia
  4. Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES. Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol. 2000 Aug;2(8):476–83. PubMed Europe PMC Scholia
  5. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, et al. The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol. 2000 Oct;20(19):7146–59. PubMed Europe PMC Scholia
  6. Garrido C, Schmitt E, Candé C, Vahsen N, Parcellier A, Kroemer G. HSP27 and HSP70: potentially oncogenic apoptosis inhibitors. Cell Cycle. 2003;2(6):579–84. PubMed Europe PMC Scholia
  7. Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, et al. Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Oncogene. 2003 Oct 2;22(43):6669–78. PubMed Europe PMC Scholia
  8. Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, et al. The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential. J Biol Chem. 2004 Jun 11;279(24):25689–95. PubMed Europe PMC Scholia