CAMKK2 pathway (WP4874)

CaMKK2 is a 66–68-kDa serine kinase, consists of unique N- and C-terminal domains and a central Ser/Thr-directed kinase domain that is followed by a regulatory domain composed of overlapping autoinhibitory and CaM-binding regions (PMID:9335539). CAMKK2 is activated once calmodulin (CALM1) binds with CAAMKK2. The most well-characterized substrates of CaMKK2 are CaMKI, CaMKIV and AMPKα. CaMKK2 phosphorylates CaMKIV, CaMKI and AMPKα on activation loop Thr residues (Thr-200, Thr-177 and Thr-172, respectively), which increases their kinase activities (PMID:9822657). CaMKK2 is present in many areas of the brain, including the olfactory bulb, hippocampus, dentate gyrus, amygdala, hypothalamus, and cerebellum (PMID:9822657, 12654522). The creation of this pathway is described in [ Najar et al].
last edited


Keshav, DeSl, Rex D A B, Egonw, Khanspers, Fehrhart, and Eweitz

Cited In


Homo sapiens



Disease Ontology: cancer

Pathway Ontology: calcium/calcium-mediated signaling pathway


Label Type Compact Identifier
MAF GeneProduct ncbigene:4094
Unknown None
VCAM1 GeneProduct ncbigene:7412
IFI44L GeneProduct None
FIS1 GeneProduct ncbigene:51024
DRP1 GeneProduct ncbigene:10059
Ca2+ Unknown None
HMOX1 GeneProduct ncbigene:3162
CALM1 GeneProduct ncbigene:801
MAP1LC3A GeneProduct ncbigene:84557
NFATC2 GeneProduct ncbigene:4773
STIM1 GeneProduct ncbigene:6786
GATM GeneProduct None
ASNS GeneProduct None
KLF1 GeneProduct None
GALNT9 GeneProduct None
FASN GeneProduct None
PFKFB2 GeneProduct None
Theasinensins Metabolite None
ERMAP GeneProduct None
RPTOR GeneProduct ncbigene:57521
NEDD4L GeneProduct None
Caulerpin Metabolite chebi:80923
ABCA1 GeneProduct None
HK2 GeneProduct None
MTOR GeneProduct ncbigene:2475
CYB5R3 GeneProduct None
CAMK1 GeneProduct ncbigene:8536
S100A8 GeneProduct None
ACACA Protein ncbiprotein:NP_942131.1
HK2 GeneProduct None
ARHGEF7 GeneProduct ncbigene:8874
EPOR GeneProduct None
FOXO3A Protein ncbiprotein:NP_001446.1
CCNE1 GeneProduct None
PFKFB2 GeneProduct None
TMEM176B GeneProduct None
Isorhamnetin Metabolite chebi:6052
Adropin Protein interpro:IPR034461
CCL5 GeneProduct None
Hydrogen sulphide GeneProduct None
TRPV4 GeneProduct None
EP300 GeneProduct ncbigene:2033
KDR GeneProduct None
SFI1 GeneProduct None
WDR35 GeneProduct None
Ramipril Metabolite chebi:8774
SMC1 GeneProduct ncbigene:8243
NRF2 GeneProduct None
MAP1LC3B GeneProduct None
CCND1 GeneProduct None
NOS3 Protein ncbiprotein:NP_000594.2
SLCO3A1 GeneProduct None
MAPK14 Protein ncbiprotein:NP_001306.1
TSPAN33 GeneProduct None
NLRP1 GeneProduct None
WFS1 GeneProduct ncbigene:7466
MAP1LC3A GeneProduct None
MAPK1 GeneProduct ncbigene:5594
MX2 GeneProduct None
Homocysteine sulfinic acid Metabolite chebi:137439
FAM132a GeneProduct None
CD28 GeneProduct None
KEAP1 GeneProduct None
MID1 GeneProduct None
Apigenin Metabolite chebi:18388
IL15 GeneProduct None
RPS6KB1 GeneProduct None
HMBS GeneProduct None
Estrogen GeneProduct None
CD28 GeneProduct None
CAMK4 GeneProduct ncbigene:814
RELA GeneProduct ncbigene:5970
VCAM1 GeneProduct ncbigene:7412
OASL GeneProduct None
CTSE GeneProduct None
Metabolites GeneProduct None
SPINT1 GeneProduct None
NOS1 GeneProduct ncbigene:4842
SREBF1 GeneProduct None
CDH1 GeneProduct None
GIT1 GeneProduct ncbigene:28964
SQSTM1 GeneProduct ncbigene:8878
MAP1LC3B GeneProduct None
RASGRP1 GeneProduct None
Withdrawal of essential amino acids GeneProduct None
PPAP2A GeneProduct None
Eugenol Metabolite chebi:4917
IRGC GeneProduct None
Glyceollin Metabolite chebi:16470
RPS6 GeneProduct None
PAK1 GeneProduct ncbiprotein:5058
CREB1 GeneProduct ncbigene:1385
HFE GeneProduct None
Quercetin Metabolite chebi:16243
WFS1 GeneProduct None
PCK2 GeneProduct None
Hypoxia Unknown None
CDC25A GeneProduct None
Oxytocin Metabolite chebi:7872
SELL GeneProduct None
TSPAN8 GeneProduct None
CHRM3 GeneProduct ncbigene:1131
TREM3 GeneProduct None
EIF4EBP1 Protein ncbiprotein:NP_004086.1
SLC2A4 GeneProduct None
ATP1B2 GeneProduct None
PLAC8 GeneProduct None
ICAM1 GeneProduct ncbigene:3383
GATM GeneProduct None
GDH1 GeneProduct ncbigene:854557
Poly unsaturated fatty acids GeneProduct None
TNF GeneProduct None
CAMKK2 GeneProduct ncbigene:10645
TBXT GeneProduct None
Laminar shear stress Unknown :Laminar shear stress
AQP1 GeneProduct None
ACACA GeneProduct None
RAC1 GeneProduct ncbigene:5879
IRS-1 Protein ncbiprotein:NP_005535.1
CXCL11 GeneProduct None
GCK GeneProduct None
SPIRE1 GeneProduct None
PARP1 GeneProduct None
Pulsed electric field GeneProduct None
CCR9 GeneProduct None
HDCA4 GeneProduct ncbigene:9759
EPOR GeneProduct None
Bupivacaine Metabolite chebi:31322
FAM20C GeneProduct None
HMOX1 GeneProduct ncbigene:3162
Betulinic acid Metabolite chebi:3087
INN GeneProduct None
CCND2 GeneProduct None
HK1 GeneProduct None
SLC2A1 GeneProduct None
CAR1 GeneProduct None
SLC25A21 GeneProduct None
RHD GeneProduct None
MAMDC2 GeneProduct None
MT1 GeneProduct None
TBC1D4 Protein ncbiprotein:NP_001273587.1
ATP10D GeneProduct None
CRTC2 GeneProduct None
MS4A3 GeneProduct None
PFKFB3 GeneProduct None
SLC38A5 GeneProduct None
AHSP GeneProduct None
CPOX GeneProduct None
RHAG GeneProduct None
Protein Protein ncbigene:5894
CREB1 GeneProduct ncbigene:1385
TSC1 GeneProduct ncbigene:7248
SIRT1 GeneProduct ncbigene:23411
AKT Protein ncbiprotein:NP_001014431.1
RPS6KB1 GeneProduct None
HIF1A GeneProduct None
HK1 GeneProduct None
PRKAA2 GeneProduct ncbiprotein:NP_006243.2
ULK1 GeneProduct None
MAPK3 GeneProduct ncbigene:5595
TSC2 Protein ncbiprotein:NP_000539.2
PRKCA Protein ncbiprotein:NP_002728.1
NRF2 GeneProduct ncbigene:4780


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