Host-pathogen interaction of human coronaviruses - MAPK signaling (WP4877)

This pathway describes the activation of the human MAPK signaling system during human coronavirus infection. The information is based on the review of Fung and Liu, Figure 7 [10.1146/annurev-micro-020518-115759]. The MAPK signaling system is an important system to regulate response to different environmental stimuli, e.g. inflammation upon an infection. Their downstream effects include regulation of cell cycle, apoptosis, differentiation and immune response. During corona virus infection three MAPK signaling pathways were studied and described. The p38 pathway (MAPK11 - 14) leads to stimulation of apoptosis via CHOP (DDIT3) while the ERK pathway (MAPK1 and MAPK3) counteracts apoptosis stimulation and supports cell survival by stimulation of ATF2 and FOS. The JNK pathway (MAPK 8-10) inhibits cell survival protein BCL2 thus stimulating apoptosis but also stimulating the AP1 complex that leads to the production of effectors to fight the infection. The interplay of apoptosis stimulation and cell survival is not yet fully understood in SARS-CoV infection.
last edited


Fehrhart, Egonw, AlexanderPico, Rex D A B, Khanspers, Marvin M2, Mkutmon, Eweitz, and Finterly

Cited In


Homo sapiens




Pathway Ontology: p38 MAPK signaling pathway signaling pathway

Disease Ontology: severe acute respiratory syndrome viral infectious disease


Label Type Compact Identifier
SARSinfection Pathway None
MAP2K1 GeneProduct ensembl:ENSG00000169032
MAP2K2 GeneProduct ensembl:ENSG00000126934
MAP3K1 GeneProduct ensembl:ENSG00000095015
MAP2K3 GeneProduct ensembl:ENSG00000034152
MAP3K9 GeneProduct ensembl:ENSG00000006432
MAP3K10 GeneProduct ensembl:ENSG00000130758
MAP3K11 GeneProduct ensembl:ENSG00000173327
MAPK9 GeneProduct ncbigene:5601
JUN GeneProduct ensembl:ENSG00000177606
FOS GeneProduct ensembl:ENSG00000170345
MAPK11 GeneProduct ncbigene:5600
MAPK13 GeneProduct ncbigene:5603
DDIT3 GeneProduct ensembl:ENSG00000175197
MAPK12 GeneProduct ncbigene:6300
MAP3K4 GeneProduct ensembl:ENSG00000085511
MAPK3 GeneProduct ncbigene:5595
MAP2K7 GeneProduct ensembl:ENSG00000076984
MAPK1 GeneProduct ncbigene:5594
ATF2 GeneProduct ensembl:ENSG00000115966
MAPK8 GeneProduct ncbigene:5599
MAP2K4 GeneProduct ensembl:ENSG00000065559
EIF4E GeneProduct ensembl:ENSG00000151247
MAPK14 GeneProduct ensembl:ENSG00000112062
S Protein wikidata:Q89458416
RPS6KA3 GeneProduct ensembl:ENSG00000177189
3a Protein uniprot:P59632
FOS GeneProduct ensembl:ENSG00000170345
BCL2 GeneProduct ensembl:ENSG00000171791
MAPK10 GeneProduct ncbigene:5602
RPS6KA2 GeneProduct ensembl:ENSG00000071242
MAP2K6 GeneProduct ensembl:ENSG00000108984
RPS6KA1 GeneProduct ensembl:ENSG00000117676
RAF1 GeneProduct ensembl:ENSG00000132155
SARS, MERS, 229Einfection Pathway None
3b Protein uniprot:P59633
VLP Protein None
7a Protein uniprot:P59635
SARS, MERS, 229E infection Pathway None
SARS, 229EIBV infection Pathway None
S Protein wikidata:Q89458416
3a Protein uniprot:P59632
7a Protein uniprot:P59635
N Protein wikidata:Q89457519
3b Protein uniprot:P59633
6 Protein uniprot:P59634
Cell survival and proliferation Pathway None
Proteinsynthesis Pathway None
Apoptosis Pathway None
Innateimmunity Pathway None
Autophagy Pathway None
IFI27 GeneProduct ncbigene:3429
BST2 GeneProduct ncbigene:684
JUNB GeneProduct ncbigene:3726
IFITM2 Protein ensembl:ENSG00000185201
IFITM3 Protein ensembl:ENSG00000142089
IFITM1 Protein ensembl:ENSG00000185885
IFI27 GeneProduct ncbigene:3429
BST2 GeneProduct ncbigene:684
IFITM2 Protein ensembl:ENSG00000185201
IFITM3 Protein ensembl:ENSG00000142089
IFITM1 Protein ensembl:ENSG00000185885


  1. Fung TS, Liu DX. Human Coronavirus: Host-Pathogen Interaction. Annu Rev Microbiol. 2019 Sep 8;73:529–57. PubMed Europe PMC Scholia