Alpha 6 beta 4 integrin signaling pathway (WP488)

Integrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligands of the alpha6 beta4 integrin are heterotrimers belonging to the laminin family including Laminin A2, Laminin B1, Laminin C1, Laminin A3, Laminin B3, Laminin C2, Laminin A5, Laminin A1 and Laminin B2 among others. Upon activation, the receptor is phosphorylated and associates with adaptor molecules Shc and Grb2, which then activate the PI 3-kinase/Akt, MAPK/NFkB and SMAD signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_1
last edited

Authors

A.Pandey, MaintBot, Khanspers, Christine Chichester, Mkutmon, and Eweitz

Cited In

Organism

Mus musculus

Communities

Annotations

Pathway Ontology: integrin mediated signaling pathway

Participants

Label Type Compact Identifier
Smad3 GeneProduct ncbigene:17127
Itga6 GeneProduct ncbigene:16403
Lamc1 GeneProduct ncbigene:226519
Lamc1 GeneProduct ncbigene:226519
Lamb1-1 GeneProduct ncbigene:16777
Cdkn1a GeneProduct ncbigene:12575
Itga6 GeneProduct ncbigene:16403
Erbb2ip GeneProduct ncbigene:59079
Pak1 GeneProduct ncbigene:18479
Prkca GeneProduct ncbigene:18750
Lama2 GeneProduct ncbigene:16773
Dsp GeneProduct ncbigene:109620
Shc1 GeneProduct ncbigene:20416
Eif6 GeneProduct ncbigene:16418
Irs2 GeneProduct ncbigene:384783
Src GeneProduct ncbigene:20779
Mst1r GeneProduct ncbigene:19882
Lamc1 GeneProduct ncbigene:226519
Vim GeneProduct ncbigene:22352
Clca3 GeneProduct ncbigene:23844
Casp3 GeneProduct ncbigene:12367
Lamc2 GeneProduct ncbigene:16782
Pik3r2 GeneProduct ncbigene:18709
Pik3cd GeneProduct ncbigene:18707
Akt1 GeneProduct ncbigene:11651
Clca5 GeneProduct ncbigene:229933
Itgb4 GeneProduct ncbigene:192897
Prkcd GeneProduct ncbigene:18753
Pik3r1 GeneProduct ncbigene:18708
Fyn GeneProduct ncbigene:14360
Mmp7 GeneProduct ncbigene:17393
Ywhae GeneProduct ncbigene:22627
Ywhah GeneProduct ncbigene:22629
Eif4e GeneProduct ncbigene:13684
Eif4ebp1 GeneProduct ncbigene:13685
Lamb2 GeneProduct ncbigene:16779
Lama3 GeneProduct ncbigene:16774
Rac1 GeneProduct ncbigene:19353
Lama5 GeneProduct ncbigene:16776
Rhoa GeneProduct ncbigene:11848
Mtor GeneProduct ncbigene:56717
Lama2 GeneProduct ncbigene:16773
Lamc1 GeneProduct ncbigene:226519
Cd151 GeneProduct ncbigene:12476
Plec1 GeneProduct ncbigene:18810
Egfr GeneProduct ncbigene:13649
Trp73 GeneProduct ncbigene:22062
Lama1 GeneProduct ncbigene:16772
Lamb1-1 GeneProduct ncbigene:16777
Grb2 GeneProduct ncbigene:14784
Rtkn GeneProduct ncbigene:20166
Rhoa GeneProduct ncbigene:11848
Lama5 GeneProduct ncbigene:16776
Itga6 GeneProduct ncbigene:16403
Bad GeneProduct ncbigene:12015
Col17a1 GeneProduct ncbigene:12821
Ptk2 GeneProduct ncbigene:14083
Lamb2 GeneProduct ncbigene:16779
Pik3r3 GeneProduct ncbigene:18710
Erbb2 GeneProduct ncbigene:13866
Ywhab GeneProduct ncbigene:54401
Rpsa GeneProduct ncbigene:16785
Irs1 GeneProduct ncbigene:16367
Itga6 GeneProduct ncbigene:16403
Lamb1-1 GeneProduct ncbigene:16777
Smad2 GeneProduct ncbigene:17126
Yes1 GeneProduct ncbigene:22612
Pik3ca GeneProduct ncbigene:18706
Pik3cb GeneProduct ncbigene:74769
Lamc1 GeneProduct ncbigene:226519
Ntn1 GeneProduct ncbigene:18208
Eif6 GeneProduct ncbigene:16418
Abl1 GeneProduct ncbigene:11350
Sfn GeneProduct ncbigene:55948
Itgb4 GeneProduct ncbigene:192897
Met GeneProduct ncbigene:17295
Itgb4 GeneProduct ncbigene:192897
Pik3cg GeneProduct ncbigene:30955
Ywhaz GeneProduct ncbigene:22631
Itgb4 GeneProduct ncbigene:192897
Dst GeneProduct ncbigene:13518
Itga6 GeneProduct ncbigene:16403
Smad3 GeneProduct ncbigene:17127
Itga6 GeneProduct ncbigene:16403
Gm2423 GeneProduct ensembl:ENSMUSG00000061724
Lamb3 GeneProduct ncbigene:16780
Itgb4 GeneProduct ncbigene:192897
Itgb4 GeneProduct ncbigene:192897
Smad2 GeneProduct ncbigene:17126
Ar GeneProduct ncbigene:11835

References