COVID-19 adverse outcome pathway (WP4891)

Experimenting with links in line with bioinformatics analysis of COVID-19 genes and AOP knowledge. Work in progress!
last edited


Penny, Fehrhart, Egonw, Evelo, and Eweitz

Cited In


Homo sapiens


Adverse Outcome Pathways COVID-19


Disease Ontology: severe acute respiratory syndrome pulmonary fibrosis viral infectious disease COVID-19

Pathway Ontology: respiratory system disease pathway signaling pathway


Label Type Compact Identifier
CCL3 GeneProduct ncbigene:6348
Positive regulation ofleukocyte activation Pathway :GO:0002696
Toll-likereceptor signaling Pathway wikipathways:WP75
TNF GeneProduct ncbigene:7124
Cytokines andinflammatoryresponse Pathway wikipathways:WP530
IL2 GeneProduct ncbigene:3558
CSF3 GeneProduct ncbigene:1440
IL8 GeneProduct ncbigene:3576
CXCL10 GeneProduct ncbigene:3627
IL6 GeneProduct ncbigene:3569
IL7 GeneProduct ncbigene:3574
IL1B GeneProduct ncbigene:3553
CCL2 GeneProduct ncbigene:6347
IL10 GeneProduct ncbigene:3586
IL2RA GeneProduct ncbigene:3559
LTF danger signalresponse pathway Pathway wikipathways:WP4478
Lung fibrosis Pathway wikipathways:WP3624
SARS-CoV-2 and ACE2 receptor:molecular mechanisms andpotential therapeutic target Pathway wikipathways:WP4883
AGT GeneProduct ncbigene:183
SARS-CoV-2 andCOVID-19 pathway Pathway wikipathways:WP4846
TMPRSS2 GeneProduct ncbigene:7113
ACE2 GeneProduct ncbigene:59272


  1. Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, et al. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res. 2000 Sep 1;87(5):E1-9. PubMed Europe PMC Scholia
  2. Labib S, Williams A, Yauk CL, Nikota JK, Wallin H, Vogel U, et al. Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes. Part Fibre Toxicol. 2016 Mar 15;13:15. PubMed Europe PMC Scholia
  3. Nymark P, Rieswijk L, Ehrhart F, Jeliazkova N, Tsiliki G, Sarimveis H, et al. A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions. Toxicol Sci. 2018 Mar 1;162(1):264–75. PubMed Europe PMC Scholia