Neuroinflammation (WP4919)

Neuroinflammation is inflammation specific to parts of the central nervous system. It can be triggered by external or internal factors, such as UV damage, inflammatory cytokines and oxidative stress. Stress on the cell leads to activation of inflammatory response pathways that involve several transcription factors such as AP-1 and NFkB, which will lead to the transcription of several proteins and/or cytokines.
last edited

Authors

Annabaya, Marvin M2, and Egonw

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: regulatory pathway pertinent to the brain stress response pathway

Participants

Label Type Compact Identifier
Calmodulin Metabolite chebi:3324
JNK GeneProduct ensembl:ENSG00000107643
COX2 GeneProduct ensembl:ENSG00000198712
ROS Pathway wikipathways:WP3941
IL-1B GeneProduct homologene:481
p50 GeneProduct ensembl:ENSG00000138303
p65 GeneProduct ensembl:ENSG00000173039
L-arginine Metabolite chebi:16467
COX1 GeneProduct ensembl:ENSG00000198804
Nitrate reductase GeneProduct brenda:1.7.99.4
NADPH Metabolite chebi:16474
JUN GeneProduct ensembl:ENSG00000177606
FOS GeneProduct ensembl:ENSG00000170345
AKT GeneProduct hgnc.symbol:391
IKKα GeneProduct ensembl:ENSG00000213341
MAPK14 GeneProduct ensembl:ENSG00000112062
Nitrate Metabolite chebi:48107
PI3K GeneProduct interpro:IPR000403
Ca2+ Metabolite chebi:29108
iNOS GeneProduct ensembl:ENSG00000007171
Nitrite Metabolite chebi:16301
TNF-α GeneProduct homologene:496
NO Metabolite chebi:16480
O2 Metabolite chebi:15379
L-citrulline Metabolite chebi:57743
MTOR GeneProduct ensembl:ENSG00000198793
IκBα GeneProduct ensembl:ENSG00000100906
NADP+ Metabolite chebi:18009
TLR4 GeneProduct ensembl:ENSG00000136869
H2O Metabolite chebi:15377
NADPH Metabolite chebi:16474
NADP+ Metabolite chebi:18009
O2 Metabolite chebi:15379
JUN GeneProduct ensembl:ENSG00000177606
p50 GeneProduct ensembl:ENSG00000138303
p65 GeneProduct ensembl:ENSG00000173039
p50 GeneProduct ensembl:ENSG00000138303
p65 GeneProduct ensembl:ENSG00000173039
IκBα GeneProduct ensembl:ENSG00000100906
IκBα GeneProduct ensembl:ENSG00000100906
p50 GeneProduct ensembl:ENSG00000138303
p65 GeneProduct ensembl:ENSG00000173039
p50 GeneProduct ensembl:ENSG00000138303
p65 GeneProduct ensembl:ENSG00000173039

References

  1. Xing B, Bachstetter AD, Van Eldik LJ. Inhibition of neuronal p38α, but not p38β MAPK, provides neuroprotection against three different neurotoxic insults. J Mol Neurosci. 2015 Feb;55(2):509–18. PubMed Europe PMC Scholia
  2. Shabab T, Khanabdali R, Moghadamtousi SZ, Kadir HA, Mohan G. Neuroinflammation pathways: a general review. Int J Neurosci. 2017 Jul;127(7):624–33. PubMed Europe PMC Scholia
  3. Liu T, Zhang L, Joo D, Sun S-C. NF-κB signaling in inflammation. Signal Transduct Target Ther. 2017;2:17023. PubMed Europe PMC Scholia