Mitochondrial complex I inhibition leading to chemical-induced Fanconi syndrome (WP4944)

This pathway is a meta-pathway that represents an updated version of the Adverse Outcome Pathway 276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome (https://aopwiki.org/aops/276). All Key Events are present as Key Event nodes, with their corresponding molecular pathways as pathway nodes.
last edited

Authors

Marvin M2, Egonw, Eweitz, and Finterly

Cited In

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Organism

Homo sapiens

Communities

Adverse Outcome Pathways

Annotations

Pathway Ontology: altered metabolic pathway

Disease Ontology: Fanconi syndrome

Participants

Label Type Compact Identifier
KE888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) Event aop.events:888
Autophagy Pathway wikipathways:WP4923
Necrosis Pathway wikipathways:WP5022
Deguelin Metabolite chebi:4357
Decreased proximal tubule vectorial transport Pathway wikipathways:WP4917
Decreased mitochondrial oxidative phosphorylation Pathway wikipathways:WP111
Apoptosis Pathway wikipathways:WP1772
Ferroptosis Pathway wikipathways:WP4313
Assembly of mitochondrial complex I Pathway wikipathways:WP4324
Oxidative stress response Pathway wikipathways:WP3941
Impaired proteostasis Pathway wikipathways:WP4918
Unfolded Protein Response Pathway wikipathways:WP4925
Rotenone Event aop.stressor:50
KE887: Inhibition, NADH-ubiquinone oxidoreductase (complex I) Event aop.events:887
KE1477: Decrease, OXPHOS Event aop.events:1477
KE1562: Decreased Na/K ATPase activity Event aop.events:1562
KE1563: Decreased proximal tubular vectorial transport Event aop.events:1563
KE1564: Chemical induced Fanconi syndrome Event aop.events:1564
KE55: N/A, Cell injury/death Event aop.events:55
KE889: Impaired, Proteostasis Event aop.events:889

References