DNA repair pathways, full network (WP4946)

DNA Repair Pathways Full Network
last edited

Authors

Daisydx, Diazflorese, Egonw, Marvin M2, DeSl, Khanspers, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: DNA repair pathway

Participants

Label Type Compact Identifier
DNA Repair Pathways Pathway None
Mismatch Repair (MMR) Pathway wikipathways:WP531
Nucleotide Excision Repair (NER) Pathway wikipathways:WP4753
Base Excision Repair (BER) Pathway wikipathways:WP4752
Homologous Recombination Repair (HR) Pathway wikipathways:WP186
Non-Homologous End Joining (NHEJ) Pathway wikipathways:WP438
Methyl-Guanine DNA Methyltransferase (MGMT) Unknown None
Fanconi Anemia Pathway (FA) Unknown None
Trans-Lesion Synthesis (TLS) Unknown None
ATM GeneProduct ensembl:ENSG00000149311
ATR GeneProduct ensembl:ENSG00000175054
Alternative End-Joining (Alt-EJ) Unknown None
RPA1 GeneProduct ensembl:ENSG00000132383
RPA2 GeneProduct ensembl:ENSG00000117748
RPA3 GeneProduct ensembl:ENSG00000106399
RFC1 GeneProduct ensembl:ENSG00000035928
MSH2 GeneProduct ensembl:ENSG00000095002
MSH3 GeneProduct ensembl:ENSG00000113318
MSH6 GeneProduct ensembl:ENSG00000116062
RFC2 GeneProduct ensembl:ENSG00000049541
RFC3 GeneProduct ensembl:ENSG00000133119
RFC4 GeneProduct ensembl:ENSG00000163918
RFC5 GeneProduct ensembl:ENSG00000111445
EXO1 GeneProduct ensembl:ENSG00000174371
PCNA GeneProduct ensembl:ENSG00000132646
MLH1 GeneProduct ensembl:ENSG00000076242
PMS2 GeneProduct ensembl:ENSG00000122512
POLE GeneProduct ensembl:ENSG00000177084
POLE2 GeneProduct ensembl:ENSG00000100479
POLE3 GeneProduct ensembl:ENSG00000148229
POLE4 GeneProduct ensembl:ENSG00000115350
POLD1 GeneProduct ensembl:ENSG00000062822
POLD2 GeneProduct ensembl:ENSG00000106628
POLD3 GeneProduct ensembl:ENSG00000077514
POLD4 GeneProduct ensembl:ENSG00000175482
LIG1 GeneProduct ensembl:ENSG00000105486
RBX1 GeneProduct ensembl:ENSG00000100387
DDB1 GeneProduct ensembl:ENSG00000167986
DDB2 GeneProduct ensembl:ENSG00000134574
CUL4A GeneProduct ensembl:ENSG00000139842
CUL4B GeneProduct ensembl:ENSG00000158290
XPC GeneProduct ensembl:ENSG00000154767
XPA GeneProduct ensembl:ENSG00000136936
RAD23A GeneProduct ensembl:ENSG00000179262
RAD23B GeneProduct ensembl:ENSG00000119318
CETN2 GeneProduct ensembl:ENSG00000147400
ERCC1 GeneProduct ensembl:ENSG00000012061
ERCC2 GeneProduct ensembl:ENSG00000104884
ERCC3 GeneProduct ensembl:ENSG00000163161
ERCC4 GeneProduct ensembl:ENSG00000175595
ERCC5 GeneProduct ensembl:ENSG00000134899
ERCC6 GeneProduct ensembl:ENSG00000225830
ERCC8 GeneProduct ensembl:ENSG00000049167
CDK7 GeneProduct ensembl:ENSG00000134058
MNAT1 GeneProduct ensembl:ENSG00000020426
CCNH GeneProduct ensembl:ENSG00000134480
GTF2H5 GeneProduct ensembl:ENSG00000272047
GTF2H2 GeneProduct ensembl:ENSG00000145736
GTF2H1 GeneProduct ensembl:ENSG00000110768
GTF2H3 GeneProduct ensembl:ENSG00000111358
GTF2H4 GeneProduct ensembl:ENSG00000213780
RPA1 GeneProduct ensembl:ENSG00000132383
RPA2 GeneProduct ensembl:ENSG00000117748
RPA3 GeneProduct ensembl:ENSG00000106399
POLE GeneProduct ensembl:ENSG00000177084
POLE2 GeneProduct ensembl:ENSG00000100479
POLE3 GeneProduct ensembl:ENSG00000148229
POLE4 GeneProduct ensembl:ENSG00000115350
POLD1 GeneProduct ensembl:ENSG00000062822
POLD2 GeneProduct ensembl:ENSG00000106628
POLD3 GeneProduct ensembl:ENSG00000077514
POLD4 GeneProduct ensembl:ENSG00000175482
PCNA GeneProduct ensembl:ENSG00000132646
RFC1 GeneProduct ensembl:ENSG00000035928
RFC2 GeneProduct ensembl:ENSG00000049541
RFC3 GeneProduct ensembl:ENSG00000133119
RFC4 GeneProduct ensembl:ENSG00000163918
RFC5 GeneProduct ensembl:ENSG00000111445
LIG1 GeneProduct ensembl:ENSG00000105486
XRCC4 GeneProduct ensembl:ENSG00000152422
XRCC5 GeneProduct ensembl:ENSG00000079246
XRCC6 GeneProduct ensembl:ENSG00000196419
WRN GeneProduct ensembl:ENSG00000165392
PRKDC GeneProduct ensembl:ENSG00000253729
DCLRE1C GeneProduct ensembl:ENSG00000152457
POLM GeneProduct ensembl:ENSG00000122678
POLL GeneProduct ensembl:ENSG00000166169
LIG4 GeneProduct ensembl:ENSG00000174405
NHEJ1 GeneProduct ensembl:ENSG00000187736
OGG1 GeneProduct ensembl:ENSG00000114026
NTHL1 GeneProduct ensembl:ENSG00000065057
NEIL2 GeneProduct ensembl:ENSG00000154328
NEIL3 GeneProduct ensembl:ENSG00000109674
APEX1 GeneProduct ensembl:ENSG00000100823
APEX2 GeneProduct ensembl:ENSG00000169188
PNKP GeneProduct ensembl:ENSG00000039650
XRCC1 GeneProduct ensembl:ENSG00000073050
POLB GeneProduct ensembl:ENSG00000070501
POLL GeneProduct ensembl:ENSG00000166169
PARP1 GeneProduct ensembl:ENSG00000143799
PARP2 GeneProduct ensembl:ENSG00000129484
HMGB1 GeneProduct ensembl:ENSG00000189403
LIG1 GeneProduct ensembl:ENSG00000105486
LIG3 GeneProduct ensembl:ENSG00000005156
UNG GeneProduct ensembl:ENSG00000076248
SMUG1 GeneProduct ensembl:ENSG00000123415
MUTYH GeneProduct ensembl:ENSG00000132781
MPG GeneProduct ensembl:ENSG00000103152
MBD4 GeneProduct ensembl:ENSG00000129071
TDG GeneProduct ensembl:ENSG00000139372
POLD1 GeneProduct ensembl:ENSG00000062822
POLD2 GeneProduct ensembl:ENSG00000106628
POLD3 GeneProduct ensembl:ENSG00000077514
POLD4 GeneProduct ensembl:ENSG00000175482
PCNA GeneProduct ensembl:ENSG00000132646
POLE GeneProduct ensembl:ENSG00000177084
POLE2 GeneProduct ensembl:ENSG00000100479
POLE3 GeneProduct ensembl:ENSG00000148229
POLE4 GeneProduct ensembl:ENSG00000115350
FEN1 GeneProduct ensembl:ENSG00000168496
NBN GeneProduct ensembl:ENSG00000104320
MRE11A GeneProduct ensembl:ENSG00000020922
RPA1 GeneProduct ensembl:ENSG00000132383
BRCA2 GeneProduct ensembl:ENSG00000139618
RAD50 GeneProduct ensembl:ENSG00000113522
RAD51 GeneProduct ensembl:ENSG00000051180
RAD52 GeneProduct ensembl:ENSG00000002016
RAD54B GeneProduct ensembl:ENSG00000197275
POLD1 GeneProduct ensembl:ENSG00000062822
POLD2 GeneProduct ensembl:ENSG00000106628
POLD3 GeneProduct ensembl:ENSG00000077514
POLD4 GeneProduct ensembl:ENSG00000175482
FANCA GeneProduct ensembl:ENSG00000187741
FANCD2 GeneProduct ensembl:ENSG00000144554
FANCC GeneProduct ensembl:ENSG00000158169
FANCN GeneProduct ensembl:ENSG00000083093
FANCM GeneProduct ensembl:ENSG00000187790
FANCL GeneProduct ensembl:ENSG00000115392
FANCJ GeneProduct ensembl:ENSG00000136492
FANCI GeneProduct ensembl:ENSG00000140525
FANCG GeneProduct ensembl:ENSG00000221829
FANCF GeneProduct ensembl:ENSG00000183161
FANCE GeneProduct ensembl:ENSG00000112039
FANCB GeneProduct ensembl:ENSG00000181544
FAAP24 GeneProduct ensembl:ENSG00000131944
FAAP100 GeneProduct ensembl:ENSG00000185504
MHF1 GeneProduct ensembl:ENSG00000175279
MHF2 GeneProduct ensembl:ENSG00000169689
FAN1 GeneProduct ensembl:ENSG00000198690
USP1 GeneProduct ensembl:ENSG00000162607
UAF1 GeneProduct ensembl:ENSG00000114742
ATR GeneProduct ensembl:ENSG00000175054
CHEK1 GeneProduct ensembl:ENSG00000149554
H2AX GeneProduct ensembl:ENSG00000188486
BRCA1 GeneProduct ensembl:ENSG00000012048
BRCA2 GeneProduct ensembl:ENSG00000139618
RAD51C GeneProduct ensembl:ENSG00000108384
LIG4 GeneProduct ensembl:ENSG00000174405
LIG1 GeneProduct ensembl:ENSG00000105486
XRCC4 GeneProduct ensembl:ENSG00000152422
XRCC5 GeneProduct ensembl:ENSG00000079246
XRCC6 GeneProduct ensembl:ENSG00000196419
PRKDC GeneProduct ensembl:ENSG00000253729
MRE11 GeneProduct ensembl:ENSG00000020922
RAD50 GeneProduct ensembl:ENSG00000113522
XRS2 GeneProduct None
TERF2 GeneProduct ensembl:ENSG00000132604
RAP1A GeneProduct ensembl:ENSG00000116473
ATM GeneProduct ensembl:ENSG00000149311
ATR GeneProduct ensembl:ENSG00000175054
REV3L GeneProduct ensembl:ENSG00000009413
REV1 GeneProduct ensembl:ENSG00000135945
POLH GeneProduct ensembl:ENSG00000170734
POLI GeneProduct ensembl:ENSG00000101751
POLK GeneProduct ensembl:ENSG00000122008
PCNA GeneProduct ensembl:ENSG00000132646
MGMT GeneProduct ensembl:ENSG00000170430

References

  1. Kee Y, D’Andrea AD. Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev. 2010 Aug 15;24(16):1680–94. PubMed Europe PMC Scholia
  2. Decottignies A. Alternative end-joining mechanisms: a historical perspective. Front Genet. 2013 Apr 2;4:48. PubMed Europe PMC Scholia
  3. Goodman MF, Woodgate R. Translesion DNA polymerases. Cold Spring Harb Perspect Biol. 2013 Oct 1;5(10):a010363. PubMed Europe PMC Scholia
  4. Klinakis A, Karagiannis D, Rampias T. Targeting DNA repair in cancer: current state and novel approaches. Cell Mol Life Sci. 2020 Feb;77(4):677–703. PubMed Europe PMC Scholia
  5. Kciuk M, Bukowski K, Marciniak B, Kontek R. Advances in DNA Repair-Emerging Players in the Arena of Eukaryotic DNA Repair. Int J Mol Sci. 2020 May 30;21(11):3934. PubMed Europe PMC Scholia