Airway smooth muscle cell contraction (WP4962)

Signal transduction pathways involved in airway smooth muscle cell contraction. Based on [https://www.resmedjournal.com/article/S0954-6111(08)00096-6/fulltext figure 1 from Belaia et al.].
last edited

Authors

Angelcymak, Khanspers, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Disease Ontology: allergic asthma

Pathway Ontology: signaling pathway

Cell Type Ontology: bronchial smooth muscle cell

Participants

Label Type Compact Identifier
MYLK GeneProduct ensembl:ENSG00000065534
Ca2+ Metabolite chebi:29108
CD38 GeneProduct ensembl:ENSG00000004468
IP3 Metabolite chebi:16595
MYL GeneProduct ensembl:ENSG00000168530
ROCK1 GeneProduct ensembl:ENSG00000067900
Calmodulin Protein uniprot:G3V226
PIP2 Metabolite chebi:18348
PLCB1 GeneProduct ensembl:ENSG00000182621
VGCC Complex None
DAG Metabolite chebi:18035
ITPR3 GeneProduct ensembl:ENSG00000096433
MLCP GeneProduct ensembl:ENSG00000213639
GDI GeneProduct ensembl:ENSG00000203879
GNAQ GeneProduct ensembl:ENSG00000156052
PKC Protein ensembl:L7RSM7
RhoGAP Protein None
GCPR GeneProduct ensembl:ENSG00000169252
IL13 Protein ensembl:ENSG00000169194
cADPR Metabolite chebi:31445
PPP1R14A GeneProduct ensembl:ENSG00000167641
Ca2+ Metabolite chebi:29108
MYL GeneProduct ensembl:ENSG00000168530
Ca2+ Metabolite chebi:29108
Ca2+ Metabolite chebi:29108
RYR GeneProduct ensembl:ENSG00000196218
SOCC Complex None
ROCC Complex None
Ca2+ Metabolite chebi:29108
Ca2+ Metabolite chebi:29108
MLCP Protein ensembl:ENSG00000213639
GTP Metabolite chebi:37565
RHOA GeneProduct ensembl:ENSG00000067560
RHOA GeneProduct ensembl:ENSG00000067560
GDP Metabolite chebi:17552
ROCK2 GeneProduct ensembl:ENSG00000134318
ROCK1 GeneProduct ensembl:ENSG00000067900
ROCK2 GeneProduct ensembl:ENSG00000134318

References

  1. Pelaia G, Renda T, Gallelli L, Vatrella A, Busceti MT, Agati S, et al. Molecular mechanisms underlying airway smooth muscle contraction and proliferation: implications for asthma. Respir Med. 2008 Aug;102(8):1173–81. PubMed Europe PMC Scholia