GPCRs, class C metabotropic glutamate, pheromone (WP501)

This pathway was created using the GPCRDB (Horn et al., 1998), (originally at The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references.
last edited


Nsalomonis, MaintBot, AlexanderPico, BruceConklin, Khanspers, Egonw, and Eweitz

Cited In


Homo sapiens



Pathway Ontology: G protein mediated signaling pathway


Label Type Compact Identifier
GPR51 GeneProduct ncbigene:9568
GRM6 GeneProduct ncbigene:2916
GRM8 GeneProduct ncbigene:2918
GPRC5B GeneProduct ncbigene:51704
GABBR1 GeneProduct ncbigene:2550
GPRC5A GeneProduct ncbigene:9052
GRM1 GeneProduct ncbigene:2911
GRM4 GeneProduct ncbigene:2914
GRM2 GeneProduct ncbigene:2912
GPRC5D GeneProduct ncbigene:55507
GPRC5C GeneProduct ncbigene:55890
GRM5 GeneProduct ncbigene:2915
GRM7 GeneProduct ncbigene:2917
CASR GeneProduct ncbigene:846
GRM3 GeneProduct ncbigene:2913


  1. Horn F, Weare J, Beukers MW, Hörsch S, Bairoch A, Chen W, et al. GPCRDB: an information system for G protein-coupled receptors. Nucleic Acids Res. 1998 Jan 1;26(1):275–9. PubMed Europe PMC Scholia
  2. Karchin R, Karplus K, Haussler D. Classifying G-protein coupled receptors with support vector machines. Bioinformatics. 2002 Jan;18(1):147–59. PubMed Europe PMC Scholia