Hypoxia-dependent self-renewal of myoblasts (WP5023)

Molecular mechanisms involved in self-renewal of satellite cells in hypoxia. Black arrows: activation of the signaling pathway / protein / molecule. Blunt red arrow: inhibition of the signaling pathway / protein / molecule. Round blue arrow: interaction between two pathways.
last edited


ExperiMed, Andra, Eweitz, and Khanspers

Cited In


Mus musculus



Cell Type Ontology: myoblast

Pathway Ontology: Notch signaling pathway Wnt signaling pathway


Label Type Compact Identifier
Hey1 GeneProduct ncbigene:15213
Hes1 GeneProduct ncbigene:15205
Hey2 GeneProduct ncbigene:15214
Hypoxia Unknown None
MYF5 GeneProduct ncbigene:17877
Myotube formation Unknown None
MYH GeneProduct ncbigene:17879
RB GeneProduct None
MYOD1 GeneProduct ncbigene:17927
CDKN1A GeneProduct ncbigene:12575
Self renewal Unknown None
PAX7 GeneProduct ncbigene:18509
MYOG GeneProduct ncbigene:17928
miR206 Rna None
Notch-pathway Pathway ncbigene:18128
MAPK14 GeneProduct hgnc.symbol:MAPK14
FoxO1 GeneProduct ncbigene:56458
HIF1a GeneProduct ncbigene:15251
WNT non canonical Pathway None
miR1 Rna None
HSP90 GeneProduct ensembl:ENSMUSG00000020048


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