Hypoxia-dependent proliferation of myoblasts (WP5024)

Molecular mechanisms involved in myogenic proliferation during hypoxia. Black arrow: activation of the signaling pathway/ protein/ molecule. Blunt red arrow: inhibition of the signaling pathway/protein/ molecule.
last edited


ExperiMed, Laurent, L Dupuis, Eweitz, and Khanspers

Cited In


Mus musculus



Cell Type Ontology: myoblast

Pathway Ontology: signaling pathway phosphatidylinositol 3-kinase-Akt signaling pathway


Label Type Compact Identifier
VEGF GeneProduct ncbigene:22339
MSTN GeneProduct ncbigene:17700
Trim63 GeneProduct ncbigene:433766
MYOD1 GeneProduct ncbigene:17927
proliferation andlate differentiation Unknown None
TSC2 GeneProduct ncbigene:22084
HGF GeneProduct ncbigene:15234
Fbxo32 GeneProduct ncbigene:67731
PI3K GeneProduct None
MYF5 GeneProduct ncbigene:17877
TSC1 GeneProduct ncbigene:64930
PI3KR1 GeneProduct None
Calcitriol Protein uniprot:P70160
AKT GeneProduct ncbigene:11651
Smad3 GeneProduct ncbigene:17127
IGF1 GeneProduct ncbigene:16000
DDIT44 GeneProduct ncbigene:74747
RHEB GeneProduct ncbigene:19744
FGF GeneProduct ncbigene:14164
AMPK GeneProduct None
MTOR1 GeneProduct ncbigene:56717
Smad2 GeneProduct ncbigene:17126
MYOG GeneProduct ncbigene:17928
Elf4E GeneProduct None


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