Hypoxia-dependent differentiation of myoblasts (WP5025)

HIF1A modulates myogenic differentiation in hypoxia. Black arrow: activation of the signaling pathway/ protein/ molecule. Blunt red arrow: inhibition of the signaling path-way/ protein/ molecule. Round blue arrow: Interaction between two pathways.
last edited


ExperiMed, Laurent, DeSl, Eweitz, and Khanspers

Cited In


Mus musculus



Pathway Ontology: regulatory pathway Notch signaling pathway Wnt signaling pathway

Cell Type Ontology: myoblast


Label Type Compact Identifier
WNT canoncialpathway Pathway None
Hypoxia Unknown None
CDKN1A GeneProduct ncbigene:12575
MAPK14 GeneProduct ncbigene:26416
MYF5 GeneProduct ncbigene:17877
MYF6 GeneProduct ncbigene:17878
Notch-pathway GeneProduct ncbigene:18128
PHD2 GeneProduct ncbigene:112405
CDNK1B GeneProduct ncbigene:12576
miR210 Rna None
HIF1AN GeneProduct ncbigene:319594
HIF1A GeneProduct ncbigene:15251
MYH GeneProduct ncbigene:17879
MYOG GeneProduct ncbigene:17928
Myotube survival Unknown None
TP53 GeneProduct None
BHLHE40 GeneProduct ncbigene:20893
VEGF GeneProduct ncbigene:22339
HGF GeneProduct ncbigene:17928


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