Prostaglandin signaling (WP5088)

This pathway describes elements of Prostaglandin signaling in Homo sapiens affected by COVID-19. Prostaglandins are amongst the many inflammatory mediators that incite a cytokine storm in COVID-19 after Bradykinin receptor B1 (BDKRB1) activation. This pathway mainly focuses on PGE2 and PGI2 and their interactions that lead to hyperinflammation via cytokine storms, immunothrombosis as well as the recruitment of fibrosis-mediating factors (VEGF, TGFB1, AREG). These pathways take place in multiple cell types such as: Monocytes, Macrophages, Fibroblasts, Th17 cells, Nk cells, et cetera.
last edited

Authors

Ariajadhav, Marvin M2, Eweitz, and Egonw

Cited In

Organism

Homo sapiens

Communities

Annotations

Disease Ontology: COVID-19

Pathway Ontology: prostaglandin E2 signaling pathway prostaglandin I2 signaling pathway

Participants

Label Type Compact Identifier
Metabolite None
cAMP Metabolite hmdb:HMDB0000058
Unknown None
GeneProduct None
Unknown None
pro-IL1B GeneProduct ensembl:ENSG00000125538
IRF7 GeneProduct ensembl:ENSG00000185507
Ca2+ efflux Metabolite chebi:29108
Prostaglandin E2 receptor Protein uniprot:G3V2Y6
Prostaglandin E2 Metabolite cas:363-24-6
Prostaglandin E receptor 4 Protein ensembl:ENSG00000171522
IFNA1 GeneProduct ensembl:ENSG00000197919
VEGFA GeneProduct ensembl:ENSG00000112715
IL6 GeneProduct ensembl:ENSG00000136244
Prostaglandin E receptor 4 Protein ensembl:ENSG00000171522
CSF1 GeneProduct ensembl:ENSG00000184371
IL6 GeneProduct ensembl:ENSG00000136244
IL8 GeneProduct ensembl:ENSG00000169429
COX2 GeneProduct None
Prostaglandin E2 Metabolite cas:363-24-6
MMP9 GeneProduct ensembl:ENSG00000100985
IL17A GeneProduct ensembl:ENSG00000112115
IL6 GeneProduct ensembl:ENSG00000136244
IL8 GeneProduct ensembl:ENSG00000169429
IL1B GeneProduct ensembl:ENSG00000125538
Prostaglandin E2 receptor Protein uniprot:G3V2Y6
CCL2 GeneProduct ensembl:ENSG00000108691
CXCL1 GeneProduct ensembl:ENSG00000163739
AREG GeneProduct ensembl:ENSG00000109321
VEGFA GeneProduct ensembl:ENSG00000112715
TGFB1 GeneProduct hgnc.symbol:TGFB1
Prostaglandin E2 receptor Protein uniprot:G3V2Y6
Prostaglandin E receptor 4 Protein ensembl:ENSG00000171522
Prostaglandin E2 receptor Protein uniprot:G3V2Y6
Prostaglandin E receptor 4 Protein ensembl:ENSG00000171522
PKA Protein kegg.genes:EC 2.7.11.11
IL17A GeneProduct ensembl:ENSG00000112115
IL17F GeneProduct ensembl:ENSG00000112116
AHR Protein ensembl:ENSG00000106546
IFNG Protein hgnc.symbol:IFNG
IL12A GeneProduct ensembl:ENSG00000168811
Prostaglandin E receptor 4 Protein ensembl:ENSG00000171522
Natural killer cells antigen CD94 Protein uniprot:E9PCX9
CXCL9 GeneProduct ensembl:ENSG00000138755
CXCL10 GeneProduct ensembl:ENSG00000169245
cAMP Metabolite hmdb:HMDB0000058
cAMP Metabolite hmdb:HMDB0000058
NFKB1 GeneProduct ensembl:ENSG00000109320
IL1B GeneProduct ensembl:ENSG00000125538
Prostaglandin I2 Metabolite cas:35121-78-9
IFNA1 GeneProduct ensembl:ENSG00000197919
IL1B GeneProduct ensembl:ENSG00000125538
IL6 GeneProduct ensembl:ENSG00000136244
TNF GeneProduct ensembl:ENSG00000232810
TNF GeneProduct ensembl:ENSG00000232810
CCL2 GeneProduct ensembl:ENSG00000108691
IL17A GeneProduct ensembl:ENSG00000112115
IFNG Protein hgnc.symbol:IFNG
IP-activated cAMP Metabolite hmdb:HMDB0000058
Prostaglandin E synthase Protein uniprot:O14684
COX2 GeneProduct None
Prostaglandin E2 Metabolite cas:363-24-6
IL6 GeneProduct ensembl:ENSG00000136244
IL8 GeneProduct ensembl:ENSG00000169429
TNF GeneProduct ensembl:ENSG00000232810
IL1A GeneProduct ensembl:ENSG00000115008
CCL2 GeneProduct ensembl:ENSG00000108691
CXCL10 GeneProduct ensembl:ENSG00000169245
CCL3 GeneProduct ensembl:ENSG00000277632
IL1B GeneProduct ensembl:ENSG00000125538
Prostaglandin E receptor 4 Protein ensembl:ENSG00000171522
Prostaglandin E2 receptor Protein uniprot:P43116
ASC GeneProduct ensembl:ENSG00000103490
NLRP3 GeneProduct ensembl:ENSG00000162711
pro-CASP1 GeneProduct ensembl:ENSG00000137752
CCR2 GeneProduct ensembl:ENSG00000121807
PI3K GeneProduct ensembl:ENSG00000105851
CD28 GeneProduct ensembl:ENSG00000178562
CASP1 GeneProduct ensembl:ENSG00000137752

References

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