Nuclear Receptors (WP509)

Nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors only happens when a liganda molecule which affects the receptor's behavioris present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both embryonic development and adult homeostasis. Source: Wikipedia ([[wikipedia:Nuclear_receptor]])
last edited


E.Tuninsky, MaintBot, Khanspers, AlexanderPico, Ddigles, and Mkutmon

Cited In


Mus musculus



Pathway Ontology: transcription factor mediated signaling pathway


Label Type Compact Identifier
Rxrb GeneProduct ncbigene:20182
Esrra GeneProduct ncbigene:26379
Rarb GeneProduct ncbigene:218772
Nr3c1 GeneProduct ncbigene:14815
Nr5a2 GeneProduct ncbigene:26424
Nr2c2 GeneProduct ncbigene:22026
Rarg GeneProduct ncbigene:19411
Nr4a2 GeneProduct ncbigene:18227
Ar GeneProduct ncbigene:11835
Pgr GeneProduct ncbigene:18667
Nr2e1 GeneProduct ncbigene:21907
Nr2f2 GeneProduct ncbigene:11819
Vdr GeneProduct ncbigene:22337
Nr5a1 GeneProduct ncbigene:26423
Thrb GeneProduct ncbigene:21834
Nr1d2 GeneProduct ncbigene:353187
Thra GeneProduct ncbigene:21833
Rorc GeneProduct ncbigene:19885
Rxrg GeneProduct ncbigene:20183
Rora GeneProduct ncbigene:19883
Ppard GeneProduct ncbigene:19015
Nr2f1 GeneProduct ncbigene:13865
Pparg GeneProduct ncbigene:19016
Ror1 GeneProduct ncbigene:26563
Nr0b1 GeneProduct ncbigene:11614
Nr4a1 GeneProduct ncbigene:15370
Rxra GeneProduct ncbigene:20181
Thrb GeneProduct ncbigene:21834
Esr2 GeneProduct ncbigene:13983
Rarg GeneProduct ncbigene:19411
Nr1h2 GeneProduct ncbigene:22260
Nr1h3 GeneProduct ncbigene:22259
Rara GeneProduct ncbigene:19401
Esr1 GeneProduct ncbigene:13982
Nr1i2 GeneProduct ncbigene:18171
Nr2f6 GeneProduct ncbigene:13864
Ppara GeneProduct ncbigene:19013
Hnf4a GeneProduct ncbigene:15378
Pparg GeneProduct ncbigene:19016
Esrrb GeneProduct ncbigene:26380
Nr1i3 GeneProduct ncbigene:12355


  1. Nagy L, Schüle R, Gronemeyer H. Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to Disease. EMBO Rep. 2006 Jun;7(6):579–84. PubMed Europe PMC Scholia