Regulation of actin cytoskeleton (WP51)

A cytoskeleton is a complex, dynamic network of interlinking protein filaments that extends from the cell nucleus to the cell membrane. Actin filaments, composed of the abundant actin protein, are a main component of the cytoskeleton, playing a key role muscle contraction. http://www.genome.jp/kegg/pathway/hsa/hsa04810.html Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP51 CPTAC Assay Portal]
last edited

Authors

169.230.77.174, MaintBot, AlexanderPico, Khanspers, Diana.gco, Ddigles, Mkutmon, Egonw, Zari, Finterly, and Eweitz

Cited In

Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: regulatory pathway cell adhesion signaling pathway

Participants

Label Type Compact Identifier
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References

  1. Fukata M, Nakagawa M, Kuroda S, Kaibuchi K. Cell adhesion and Rho small GTPases. J Cell Sci. 1999 Dec;112 ( Pt 24):4491–500. PubMed Europe PMC Scholia
  2. Schmitz AA, Govek EE, Böttner B, Van Aelst L. Rho GTPases: signaling, migration, and invasion. Exp Cell Res. 2000 Nov 25;261(1):1–12. PubMed Europe PMC Scholia
  3. Sastry SK, Burridge K. Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics. Exp Cell Res. 2000 Nov 25;261(1):25–36. PubMed Europe PMC Scholia
  4. Takai Y, Sasaki T, Matozaki T. Small GTP-binding proteins. Physiol Rev. 2001 Jan;81(1):153–208. PubMed Europe PMC Scholia
  5. Pollard TD. The cytoskeleton, cellular motility and the reductionist agenda. Nature. 2003 Apr 17;422(6933):741–5. PubMed Europe PMC Scholia
  6. Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, et al. Cell migration: integrating signals from front to back. Science. 2003 Dec 5;302(5651):1704–9. PubMed Europe PMC Scholia
  7. Burridge K, Wennerberg K. Rho and Rac take center stage. Cell. 2004 Jan 23;116(2):167–79. PubMed Europe PMC Scholia