Network map of SARS-CoV-2 signaling pathway (WP5115)

A schematic representation of the SARS-CoV-2 signaling pathway. The pathway map represents protein-protein interactions and the downstream molecular events regulated by SARS-CoV-2 including molecular association, catalysis, and gene regulation events. Each events are color coded as described in the pathway legend. Information pertaining to site and residue of post-translational modification are also included in the pathway map.
last edited


Keshav, Fehrhart, Eweitz, Egonw, and Susan

Cited In


Homo sapiens



Disease Ontology: severe acute respiratory syndrome

Pathway Ontology: disease pathway respiratory system disease pathway


Label Type Compact Identifier
Cytochrome C Metabolite chebi:18070
SARS-CoV-2 Pathway wikipathways:WP4846
S Protein ncbiprotein:BCD58753
ACE2 Protein ensembl:ENSG00000130234
TMPRSS2 Protein ncbigene:7226
SARS-CoV-2 Pathway wikipathways:WP4846
OS9 GeneProduct None
MARK2 GeneProduct None
TBKBP1 GeneProduct None
CLCC1 GeneProduct None
FAM98A GeneProduct None
SIGMAR1 GeneProduct None
ERLEC1 GeneProduct None
TLE1 GeneProduct None
SDF2 GeneProduct None
GTF2F2 GeneProduct None
UGGT2 GeneProduct None
NEK9 GeneProduct None
G3BP2 GeneProduct None
NPTX1 GeneProduct None
ATP6AP1 GeneProduct None
TLE3 GeneProduct None
ATP13A3 GeneProduct None
MOV10 GeneProduct None
UPF1 GeneProduct None
TLE5 GeneProduct None
ADAM9 GeneProduct None
G3BP1 GeneProduct None
MIB1 GeneProduct None
SRP72 GeneProduct None
SRP54 GeneProduct None
SRP19 GeneProduct None
ATE1 GeneProduct None
GGH GeneProduct None
LARP1 GeneProduct None
MDN1 GeneProduct None
TOMM70 GeneProduct None
TRIM59 GeneProduct None
NSP6 Protein ncbiprotein:YP_009725302
ORF7b Protein ncbiprotein:BCD58759
ORF3a Protein ncbiprotein:BCD58754
NSP10 Protein ncbiprotein:YP_009725306
M Protein ncbiprotein:BCD58756
S Protein ncbiprotein:BCD58753
NSP2 Protein ncbiprotein:YP_009725298
ORF6 Protein ncbiprotein:BCD58757
NSP9 Protein ncbiprotein:YP_009725305
N Protein ncbiprotein:N
ORF9b Protein ncbiprotein:ORF9b
NSP13 Protein ncbiprotein:NSP13
NSP8 Protein ncbiprotein:NSP8
ORF7a Protein ncbiprotein:ORF7a
ORF8 Protein ncbiprotein:ORF8
RTN4 GeneProduct None
PITRM1 GeneProduct None
COQ8B GeneProduct None
PMPCB GeneProduct None
INTS4 GeneProduct None
CASP3 GeneProduct ensembl:ENSG00000164305
BID Protein ncbigene:637
CASP8 GeneProduct hgnc.symbol:CASP8
CASP9 GeneProduct hgnc.symbol:CASP9
BID Protein ncbigene:637
STAT1 GeneProduct hgnc.symbol:STAT1
JAK2 GeneProduct hgnc.symbol:JAK2
MYD88 GeneProduct hgnc.symbol:MYD88
IRAK1 GeneProduct ncbigene:3654
TRAF6 GeneProduct ncbigene:7189
TLRs GeneProduct None
NFKB2 Protein ncbigene:4791
TGFBR2 Protein hgnc.symbol:TGFBR2
SMAD5 GeneProduct ncbigene:4090
SMAD1 GeneProduct ncbigene:4086
FGB GeneProduct hgnc.symbol:FGB
SERPINE1 GeneProduct hgnc.symbol:SERPINE1
FGG GeneProduct hgnc.symbol:FGG
ITGA3 GeneProduct hgnc.symbol:ITGA3
COL7A1 GeneProduct hgnc.symbol:COL7A1
FN1 GeneProduct hgnc.symbol:FN1
MAPK8 Protein ncbiprotein:NP_001310259.1
FOS GeneProduct hgnc.symbol:FOS
EGR1 GeneProduct hgnc.symbol:EGR1
PTGS2 GeneProduct hgnc.symbol:PTGS2
JUN GeneProduct hgnc.symbol:JUN
DUSP1 GeneProduct hgnc.symbol:DUSP1
ITCH GeneProduct hgnc.symbol:ITCH
MAVS GeneProduct ensembl:ENSG00000088888
TANK GeneProduct ena.embl:TANK
TRAF2 GeneProduct hgnc.symbol:TRAF2
CXCL2 GeneProduct hgnc.symbol:CXCL2
TNF GeneProduct hgnc.symbol:TNF
IL6 GeneProduct hgnc.symbol:IL6
TRAF3 GeneProduct ensembl:ENSG00000131323
IRF3 GeneProduct hgnc.symbol:IRF3
ISG56 GeneProduct hgnc.symbol:ISG56
ISRE GeneProduct hgnc.symbol:ISRE
MX1 GeneProduct hgnc.symbol:MX1
IFIT1 GeneProduct hgnc.symbol:IFIT1
IRF9 GeneProduct hgnc.symbol:IRF9
IFN1 Protein uniprot:IFN1
IFNB1 Protein uniprot:P01574
MAPK1 Protein ncbiprotein:NP_002736.3
MAPK3 Protein ncbiprotein:NP_002737.2
PLA2G4A Protein ncbiprotein:NP_077734.1
MAPK14 Protein ncbiprotein:NP_001306.1
IFI27 GeneProduct hgnc.symbol:IFI27
BST2 GeneProduct hgnc.symbol:BST2
IFI6 GeneProduct hgnc.symbol:IFI6
IFITM1 GeneProduct hgnc.symbol:IFITM1
FOS GeneProduct hgnc.symbol:FOS
JUN GeneProduct hgnc.symbol:JUN
DUSP1 GeneProduct hgnc.symbol:DUSP1
IRF27 GeneProduct hgnc.symbol:IRF27
JUNB GeneProduct hgnc.symbol:JUNB
IFITM3 GeneProduct hgnc.symbol:IFITM3
IFI27 GeneProduct hgnc.symbol:IFI27
IFIH1 GeneProduct hgnc.symbol:IFIH1
IFNB1 Protein uniprot:P01574
ACE2 GeneProduct ensembl:ENSG00000130234
CXCL8 GeneProduct hgnc.symbol:CXCL8
CCL11 GeneProduct hgnc.symbol:CCL11
IL6 GeneProduct ensembl:ENSG00000136244
CXCL9 GeneProduct hgnc.symbol:CXCL9
CCR5 GeneProduct hgnc.symbol:CCR5
CXCR1 GeneProduct hgnc.symbol:CXCR1
CXCR2 GeneProduct hgnc.symbol:CXCR2
TNF GeneProduct hgnc.symbol:TNF
IL1RA GeneProduct hgnc.symbol:IL1RA
CCL20 GeneProduct hgnc.symbol:CCL20
IL6 GeneProduct ensembl:ENSG00000136244
CXCL6 GeneProduct hgnc.symbol:CXCL6
CD226 GeneProduct hgnc.symbol:CD226
CCR6 GeneProduct hgnc.symbol:CCR6
CXCL16 GeneProduct hgnc.symbol:CXCL16
CXCL9 GeneProduct hgnc.symbol:CXCL9
CXCL1 GeneProduct hgnc.symbol:CXCL1
IL1A GeneProduct hgnc.symbol:IL1A
CXCL2 GeneProduct hgnc.symbol:CXCL2
CD163 GeneProduct hgnc.symbol:CD163
CXCL16 GeneProduct hgnc.symbol:CXCL16
CXCR7 GeneProduct hgnc.symbol:CXCR7
CXCL3 GeneProduct hgnc.symbol:CXCL3
CXCL2 GeneProduct hgnc.symbol:CXCL2
IL1B GeneProduct ensembl:ENSG00000125538
CCL8 GeneProduct hgnc.symbol:CCL8
CXCL5 GeneProduct hgnc.symbol:CXCL5
CXCL8 GeneProduct hgnc.symbol:CXCL8
CCL2 GeneProduct ensembl:ENSG00000108691
IL8 GeneProduct ncbigene:3576
NKRF GeneProduct ncbigene:55922
IL6 GeneProduct ncbigene:3569
SQSTM1 Protein ncbiprotein:NP_003891.1
MAP1LC3B GeneProduct ncbigene:81631
TAX1BP1 Protein ncbiprotein:TAX1BP1
NBR1 Protein ncbiprotein:NBR1
GABARAPL2 Protein ncbigene:11345
VPS16 Protein ncbigene:64601
VPS11 Protein ncbigene:55823
VPS41 Protein ncbigene:27072
VPS18 GeneProduct hgnc.symbol:VPS18
VPS36 Protein ncbigene:51028
VPS33A Protein ncbigene:65082
RPS6KB1 Protein ncbiprotein:NP_003152.1
MLST8 Protein ncbigene:64223
DEPTOR Protein ncbigene:64798
RPTOR Protein ncbigene:57521
RHEB Protein ncbigene:6009
LARP1 GeneProduct ncbigene:23367
ATG13 Protein ncbigene:9776
ULK1 GeneProduct ncbigene:8408
AKT1 Protein uniprot:P31749
TSC2 Protein uniprot:P31749
EIF4E Protein hgnc.symbol:EIF4E
PI3K Protein uniprot:P31749
HIF1A GeneProduct ncbigene:3091
PRAS40 GeneProduct ensembl:ENSG00000204673
EIF4EBP1 GeneProduct ncbigene:1978
MTOR Protein ncbigene:2475
TNF GeneProduct hgnc.symbol:TNF
CCL8 GeneProduct hgnc.symbol:CCL8
STEAP3 GeneProduct hgnc.symbol:STEAP3
PIAS1 GeneProduct hgnc.symbol:PIAS1
IL17A GeneProduct hgnc.symbol:IL17A
FGA GeneProduct ensembl:ENSG00000171560
SELP GeneProduct ensembl:ENSG00000174175
IFITM3 GeneProduct ensembl:ENSG00000142089
GTSE1 GeneProduct hgnc.symbol:GTSE1
MIP1A GeneProduct hgnc.symbol:MIP1A
IL6 GeneProduct hgnc.symbol:IL6
IL6 GeneProduct hgnc.symbol:IL6
HSPA8 GeneProduct hgnc.symbol:HSPA8
CFP GeneProduct hgnc.symbol:CFP
FGB GeneProduct ensembl:ENSG00000171564
JAK1 GeneProduct hgnc.symbol:JAK1
GMCSF GeneProduct hgnc.symbol:GMCSF
IFI27 GeneProduct hgnc.symbol:IFI27
LCK GeneProduct hgnc.symbol:LCK
CCL27 GeneProduct hgnc.symbol:CCL27
IL1A GeneProduct hgnc.symbol:IL1A
C8A GeneProduct ensembl:ENSG00000157131
CCL26 GeneProduct hgnc.symbol:CCL26
CAMK4 GeneProduct hgnc.symbol:CAMK4
SAA1 GeneProduct ensembl:ENSG00000173432
RPS6 GeneProduct hgnc.symbol:RPS6
IL2R GeneProduct hgnc.symbol:IL2R
CCL5 GeneProduct hgnc.symbol:CCL5
IGFBP3 GeneProduct hgnc.symbol:IGFBP3
CCL1 GeneProduct hgnc.symbol:CCL1
TP53I3 GeneProduct hgnc.symbol:TP53I3
CRP GeneProduct hgnc.symbol:CRP
EIF4A2 GeneProduct hgnc.symbol:EIF4A2
ITIH4 GeneProduct ensembl:ENSG00000055955
GCSF GeneProduct hgnc.symbol:GCSF
WDR74 GeneProduct hgnc.symbol:WDR74
CCL4 GeneProduct hgnc.symbol:CCL4
BIRC5 GeneProduct hgnc.symbol:BIRC5
AHR GeneProduct hgnc.symbol:AHR
TNFSF10 GeneProduct hgnc.symbol:TNFSF10
IL18 GeneProduct hgnc.symbol:IL18
CXCL12 GeneProduct hgnc.symbol:CXCL12
MIP1B GeneProduct hgnc.symbol:MIP1B
IL22 GeneProduct hgnc.symbol:IL22
MCP1 GeneProduct hgnc.symbol:MCP1
HRG GeneProduct hgnc.symbol:HRG
GSN GeneProduct hgnc.symbol:GSN
TRO GeneProduct hgnc.symbol:TRO
CCL4 GeneProduct hgnc.symbol:CCL4
ACTB GeneProduct ensembl:ENSG00000075624
CCL21 GeneProduct hgnc.symbol:CCL21
PF4 GeneProduct hgnc.symbol:PF4
IFNG GeneProduct hgnc.symbol:IFNG
APOH GeneProduct hgnc.symbol:APOH
IL1B GeneProduct hgnc.symbol:IL1B
CTSD GeneProduct hgnc.symbol:CTSD
HBB GeneProduct hgnc.symbol:HBB
IL2B GeneProduct hgnc.symbol:IL2B
PDGF GeneProduct hgnc.symbol:PDGF
CXCL9 GeneProduct hgnc.symbol:CXCL9
HP GeneProduct ensembl:ENSG00000257017
IL1RA GeneProduct hgnc.symbol:IL1RA
OAS2 GeneProduct hgnc.symbol:OAS2
IL8 GeneProduct hgnc.symbol:IL8
LRG1 GeneProduct ensembl:ENSG00000171236
C1S GeneProduct ensembl:ENSG00000182326
APOM GeneProduct hgnc.symbol:APOM
CXCL10 GeneProduct hgnc.symbol:CXCL10
FGF2 GeneProduct hgnc.symbol:FGF2
APOA2 GeneProduct hgnc.symbol:APOA2
ACTG1 GeneProduct ensembl:ENSG00000184009
SKAP1 GeneProduct hgnc.symbol:SKAP1
C1QBP GeneProduct hgnc.symbol:C1QBP
CTSD GeneProduct hgnc.symbol:CTSD
CPN1 GeneProduct hgnc.symbol:CPN1
APOA1 GeneProduct hgnc.symbol:APOA1
IL33 GeneProduct hgnc.symbol:IL33
APOL1 GeneProduct hgnc.symbol:APOL1
DDIT4 GeneProduct hgnc.symbol:DDIT4
BTN3A1 GeneProduct hgnc.symbol:BTN3A1
CARD11 GeneProduct hgnc.symbol:CARD11
IL1R2 GeneProduct hgnc.symbol:IL1R2
NFATC3 GeneProduct hgnc.symbol:NFATC3
IL5 GeneProduct hgnc.symbol:IL5
CEBPB GeneProduct hgnc.symbol:CEBPB
PARP2 GeneProduct hgnc.symbol:PARP2
CCL3 GeneProduct hgnc.symbol:CCL3
CTSZ GeneProduct hgnc.symbol:CTSZ
IP10 GeneProduct hgnc.symbol:IP10
CCNB2 GeneProduct hgnc.symbol:CCNB2
JUNB GeneProduct hgnc.symbol:JUNB
FAM83A GeneProduct hgnc.symbol:FAM83A
CXCL13 GeneProduct hgnc.symbol:CXCL13
IL10 GeneProduct hgnc.symbol:IL10
APOC1 GeneProduct hgnc.symbol:APOC1
LCK GeneProduct hgnc.symbol:LCK
C1R GeneProduct ensembl:ENSG00000159403
CASP5 GeneProduct hgnc.symbol:CASP5
CCL2 GeneProduct hgnc.symbol:CCL2
CALC1 GeneProduct hgnc.symbol:CALC1
FGG GeneProduct ensembl:ENSG00000171557
A1BG GeneProduct ensembl:ENSG00000121410
FYN GeneProduct hgnc.symbol:FYN
IL7 GeneProduct hgnc.symbol:IL7
CTSB GeneProduct hgnc.symbol:CTSB
RAC1 GeneProduct hgnc.symbol:RAC1
CFH GeneProduct ensembl:ENSG00000000971
IL13 GeneProduct hgnc.symbol:IL13
ITIH3 GeneProduct ensembl:ENSG00000162267
HBD GeneProduct hgnc.symbol:HBD
TNF GeneProduct hgnc.symbol:TNF
CD14 GeneProduct ensembl:ENSG00000170458
SERPINA10 GeneProduct ensembl:ENSG00000140093
PTPN6 GeneProduct hgnc.symbol:PTPN6
LGALS3BP GeneProduct ensembl:ENSG00000108679
MAPK8 GeneProduct hgnc.symbol:MAPK8
IL1B GeneProduct hgnc.symbol:IL1B
CXCL10 GeneProduct hgnc.symbol:CXCL10
CFI GeneProduct ensembl:ENSG00000205403
CDK1 GeneProduct hgnc.symbol:CDK1
CCL22 GeneProduct hgnc.symbol:CCL22
LDH GeneProduct hgnc.symbol:LDH
CRP GeneProduct ensembl:ENSG00000132693
LBP GeneProduct ensembl:ENSG00000129988
IL16 GeneProduct hgnc.symbol:IL16
VEGFA GeneProduct None
CCL15 GeneProduct hgnc.symbol:CCL15
PRKCQ GeneProduct hgnc.symbol:PRKCQ
RRAS GeneProduct hgnc.symbol:RRAS
TNF GeneProduct hgnc.symbol:TNF
SAA2 GeneProduct ensembl:ENSG00000134339
IL10 GeneProduct hgnc.symbol:IL10
IFNA GeneProduct hgnc.symbol:IFNA
IL9 GeneProduct hgnc.symbol:IL9
IL18RAP GeneProduct hgnc.symbol:IL18RAP
CCL2 GeneProduct hgnc.symbol:CCL2
IL23 GeneProduct hgnc.symbol:IL23
TF GeneProduct hgnc.symbol:TF
IL21 GeneProduct hgnc.symbol:IL21
CFB GeneProduct ensembl:ENSG00000243649
CCL3 GeneProduct hgnc.symbol:CCL3
IL4 GeneProduct hgnc.symbol:IL4
RRM2 GeneProduct hgnc.symbol:RRM2
CCL2 GeneProduct hgnc.symbol:CCL2
APOD GeneProduct hgnc.symbol:APOD
CTSB GeneProduct hgnc.symbol:CTSB
IGLC2 GeneProduct ncbigene:3538
APOA1 GeneProduct hgnc.symbol:APOA1
IL1A GeneProduct hgnc.symbol:IL1A
IGHE GeneProduct ncbigene:3497
HLA-DRA GeneProduct ncbigene:3122
SERPINA5 GeneProduct hgnc.symbol:SERPINA5
CD4 GeneProduct ncbigene:920
CD8A GeneProduct ncbigene:926
IL10 GeneProduct hgnc.symbol:IL10
HLA-DRB1 GeneProduct ncbigene:3123
ALB GeneProduct hgnc.symbol:ALB
IGLL1 GeneProduct ncbigene:3543
PRG3 GeneProduct ncbigene:10394
CD8A GeneProduct ncbigene:925
CRP GeneProduct ncbigene:1401
TPO GeneProduct hgnc.symbol:TPO
MMP25 GeneProduct ncbigene:64386
NLRP3 GeneProduct hgnc.symbol:NLRP3
JUNB GeneProduct hgnc.symbol:JUNB
IFI6 GeneProduct hgnc.symbol:IFI6
IFI44L GeneProduct hgnc.symbol:IFI44L
CCNB1 GeneProduct hgnc.symbol:CCNB1
LBP GeneProduct ncbigene:3929
HLA-DRB4 GeneProduct ncbigene:3126
IGHG4 GeneProduct ncbigene:3503
GP1BA GeneProduct hgnc.symbol:GP1BA
NTRK1 GeneProduct hgnc.symbol:NTRK1
IGHG2 GeneProduct ncbigene:3501
CTSL GeneProduct hgnc.symbol:CTSL
CD2 GeneProduct ncbigene:914
CTSL GeneProduct hgnc.symbol:CTSL
NLRP1 GeneProduct ncbigene:22861
HLA-DRB5 GeneProduct ncbigene:3127
IL1B GeneProduct hgnc.symbol:IL1B
IGHG1 GeneProduct ncbigene:3500
CD247 GeneProduct ncbigene:919
CD3G GeneProduct ncbigene:917
LCK GeneProduct ncbigene:3932
CD3E GeneProduct ncbigene:916
ZAP70 GeneProduct ncbigene:7535
TRBC1 GeneProduct ncbigene:28639
FYN GeneProduct ncbigene:2534
TRAC GeneProduct ncbigene:28755
TBK1 GeneProduct ncbigene:29110
DDX58 GeneProduct hgnc.symbol:DDX58
IKBKG Protein ncbigene:8517
GeneProduct HGNC
GeneProduct HGNC
RAP1GDS1 GeneProduct None
TNF GeneProduct hgnc.symbol:TNF
AGT GeneProduct hgnc.symbol:AGT
IFNA GeneProduct hgnc.symbol:IFNA
IL17A GeneProduct hgnc.symbol:IL17A
CXCL5 GeneProduct hgnc.symbol:CXCL5
LDH GeneProduct hgnc.symbol:LDH
CRP GeneProduct hgnc.symbol:CRP
MCP1 GeneProduct hgnc.symbol:MCP1
CXCL10 GeneProduct hgnc.symbol:CXCL10
CXCL1 GeneProduct hgnc.symbol:CXCL1
IL1B GeneProduct hgnc.symbol:IL1B
IL10 GeneProduct hgnc.symbol:IL10
LDH GeneProduct hgnc.symbol:LDH
IL1A GeneProduct hgnc.symbol:IL1A
IL12A GeneProduct hgnc.symbol:IL12A
CRP GeneProduct hgnc.symbol:CRP
IL6 GeneProduct hgnc.symbol:IL6
ALB GeneProduct hgnc.symbol:ALB


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