Catecholamine synthesis (WP513)

This pathway was created using information from: * http://biocyc.org/META/new-image?type=PATHWAY&object=PWY66-301 * http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/AminoAcid/dopa.html * http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/AminoAcid/PheTyr.html * http://www.genome.ad.jp/dbget-bin/www_bget?pathway+map00350 * http://www.genome.jp/dbget-bin/get_pathway?org_name=rno&mapno=00400 (phenylalanine -> tyrosine)
last edited

Authors

Annemichielsen, Thomas, Noortjevdvorst, AlexanderPico, MaintBot, Khanspers, Christine Chichester, and Egonw

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: catecholamine biosynthetic pathway

Participants

Label Type Compact Identifier
O2 Metabolite None
L-DOPA Metabolite hmdb:HMDB0000609
Dopamine Metabolite hmdb:HMDB0000073
Adrenaline Metabolite hmdb:HMDB0000068
Dbh GeneProduct ncbigene:25699
4a-hydroxy-tetrahydrobiopterin Metabolite pubchem.compound:23724532
Phenylalanine Metabolite hmdb:HMDB0000159
Ascorbate Metabolite hmdb:HMDB0000044
Pah GeneProduct ncbigene:24616
O2 Metabolite None
O2 Metabolite None
Noradrenaline Metabolite hmdb:HMDB0000216
Th GeneProduct ncbigene:25085
CO2 Metabolite None
L-tyrosine Metabolite hmdb:HMDB0000158
Ddc GeneProduct ncbigene:24311
H2O Metabolite None
AdoHcy Metabolite hmdb:HMDB0000939
Pnmt GeneProduct ncbigene:24661
AdoMet Metabolite pubchem.compound:90473
tetrahydrobiopterin Metabolite hmdb:HMDB0000027
tetrahydrobiopterin Metabolite hmdb:HMDB0000027
Dehydroascorbate Metabolite hmdb:HMDB0001264
4a-hydroxy-tetrahydrobiopterin Metabolite pubchem.compound:23724532

References

  1. Christenson JG, Dairman W, Udenfriend S. On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine). Proc Natl Acad Sci U S A. 1972 Feb;69(2):343–7. PubMed Europe PMC Scholia
  2. Guroff G, Rhoads CA. Phenylalanine hydroxylation by Pseudomonas species (ATCC 11299a). Nature of the cofactor. J Biol Chem. 1969 Jan 10;244(1):142–6. PubMed Europe PMC Scholia
  3. Friedman S, Kaufman S. 3,4-dihydroxyphenylethylamine beta-hydroxylase. Physical properties, copper content, and role of copper in the catalytic acttivity. J Biol Chem. 1965 Dec;240(12):4763–73. PubMed Europe PMC Scholia
  4. Ikeda M, Levitt M, Udenfriend S. Phenylalanine as substrate and inhibitor of tyrosine hydroxylase. Arch Biochem Biophys. 1967 May;120(2):420–7. PubMed Europe PMC Scholia
  5. El Mestikawy S, Glowinski J, Hamon M. Tyrosine hydroxylase activation in depolarized dopaminergic terminals--involvement of Ca2+-dependent phosphorylation. Nature. 1983 Apr 28;302(5911):830–2. PubMed Europe PMC Scholia
  6. Carr RT, Balasubramanian S, Hawkins PC, Benkovic SJ. Mechanism of metal-independent hydroxylation by Chromobacterium violaceum phenylalanine hydroxylase. Biochemistry. 1995 Jun 6;34(22):7525–32. PubMed Europe PMC Scholia
  7. Goodwill KE, Sabatier C, Marks C, Raag R, Fitzpatrick PF, Stevens RC. Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseases. Nat Struct Biol. 1997 Jul;4(7):578–85. PubMed Europe PMC Scholia
  8. WEISSBACH H, BOGDANSKI DF, REDFIELD BG, UDENFRIEND S. Studies on the effect of vitamin B6 on 5-hydroxytryptamine (serotonin) formation. J Biol Chem. 1957 Aug;227(2):617–24. PubMed Europe PMC Scholia
  9. LOVENBERG W, WEISSBACH H, UDENFRIEND S. Aromatic L-amino acid decarboxylase. J Biol Chem. 1962 Jan;237:89–93. PubMed Europe PMC Scholia