Hypertrophy model (WP516)

Model of the effects of resistance exercise on gene regulation in human quadriceps muscle after an acute bout of isotonic exercise. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP516 CPTAC Assay Portal]
last edited


Alexander C. Zambon , Maintenance bot , David Robelin , Thomas Kelder , Kristina Hanspers , Alex Pico , Jonathan Mlius , Marianthi Kalafati , Andika Tan , Egon Willighagen , and Eric Weitz

Cited In


Homo sapiens




Disease Ontology: heart disease

Pathway Ontology: hypertrophic cardiomyopathy pathway disease pathway

Cell Type Ontology: cardiac muscle cell muscle cell


Label Type Compact Identifier
WDR1 GeneProduct ncbigene:9948
EIF4EBP1 GeneProduct ncbigene:1978
IL1R1 GeneProduct ncbigene:3554
NR4A3 GeneProduct ncbigene:8013
IL1A GeneProduct ncbigene:3552
IFNG GeneProduct ncbigene:3458
EIF4E GeneProduct ncbigene:1977
VEGF GeneProduct ncbigene:7422
ATF3 GeneProduct ncbigene:467
TCF8 GeneProduct ncbigene:6935
JUND GeneProduct ncbigene:3727
GDF8 GeneProduct ncbigene:2660
ADAM10 GeneProduct ncbigene:102
CYR61 GeneProduct ncbigene:3491
ANKRD1 GeneProduct ncbigene:27063
DUSP14 GeneProduct ncbigene:11072
HBEGF GeneProduct ncbigene:1839
IFRD1 GeneProduct ncbigene:3475
MYOG GeneProduct ncbigene:4656
IL18 GeneProduct ncbigene:3606


  1. Zambon AC, McDearmon EL, Salomonis N, Vranizan KM, Johansen KL, Adey D, et al. Time- and exercise-dependent gene regulation in human skeletal muscle. Genome Biol. 2003;4(10):R61. PubMed Europe PMC Scholia