Notch signaling pathway (WP517)

The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes.
last edited

Authors, MaintBot, Thomas, Mushtong, Ddigles, Khanspers, L Dupuis, and Eweitz

Cited In


Rattus norvegicus



Pathway Ontology: Notch signaling pathway


Label Type Compact Identifier
NP_001100467.1 GeneProduct ensembl:ENSRNOG00000003268
PSEN2 GeneProduct ncbigene:81751
APH1B GeneProduct ncbigene:300802
NP_001102074.1 GeneProduct ensembl:ENSRNOG00000026295
NP_001100551.1 GeneProduct ensembl:ENSRNOG00000001708
RGD1566181_predicted GeneProduct ensembl:ENSRNOG00000005129
Dll3 GeneProduct ensembl:ENSRNOG00000019338
Jag2 GeneProduct ensembl:ENSRNOG00000013927
HDAC1 GeneProduct ncbigene:297893
Jag1 GeneProduct ensembl:ENSRNOG00000007443
LOC688965 GeneProduct ensembl:ENSRNOG00000001432
Q2LC87_RAT GeneProduct ensembl:ENSRNOG00000009653
Lfng GeneProduct ensembl:ENSRNOG00000001250
NM_001108334.1 GeneProduct ensembl:ENSRNOG00000001004
Tnf GeneProduct ensembl:ENSRNOG00000000837
PTCRA GeneProduct ncbigene:116462
Dvl2 GeneProduct ensembl:ENSRNOG00000017915
Crebbp GeneProduct ensembl:ENSRNOG00000005330
NP_001102523.1 GeneProduct ensembl:ENSRNOG00000023400
NP_001100520.1 GeneProduct ensembl:ENSRNOG00000018364
Aph1a GeneProduct ensembl:ENSRNOG00000023816
Notch3 GeneProduct ensembl:ENSRNOG00000004346
DTX1 GeneProduct None
Adam17 GeneProduct ensembl:ENSRNOG00000007503
Notch2 GeneProduct ensembl:ENSRNOG00000018835
Dll1 GeneProduct ensembl:ENSRNOG00000014667
RBP-J GeneProduct None
DVL1 GeneProduct ncbigene:83721
NP_001101230.1 GeneProduct ensembl:ENSRNOG00000014011
Numbl GeneProduct ensembl:ENSRNOG00000020867
RFNG GeneProduct ncbigene:60433
Ncstn GeneProduct ensembl:ENSRNOG00000005355
Notch4 GeneProduct ensembl:ENSRNOG00000000442
NOTC1_RAT GeneProduct ensembl:ENSRNOG00000019322
Kcnj5 GeneProduct ncbigene:29713
Ctbp1 GeneProduct ensembl:ENSRNOG00000005428
Inpp5k GeneProduct ensembl:ENSRNOG00000004041
Mfng GeneProduct ensembl:ENSRNOG00000008133
Hes5 GeneProduct ensembl:ENSRNOG00000013850
Hes1 GeneProduct ensembl:ENSRNOG00000001720
Dtx4 GeneProduct ensembl:ENSRNOG00000021086
Psen1 GeneProduct ensembl:ENSRNOG00000009110
NP_001101145.1 GeneProduct ensembl:ENSRNOG00000013333
Ctbp2 GeneProduct ensembl:ENSRNOG00000017326
Pcaf GeneProduct ensembl:ENSRNOG00000011871
HDAC2 GeneProduct ensembl:ENSRNOG00000038246


  1. Weinmaster G. The ins and outs of notch signaling. Mol Cell Neurosci. 1997;9(2):91–102. PubMed Europe PMC Scholia