G13 signaling pathway (WP520)

The G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cells and is essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells. Source: [[wikipedia:G12/G13_alpha_subunits|Wikipedia]]
last edited

Authors

A.Chow, MaintBot, M.Ramirez, Thomas, Christine Chichester, Mkutmon, and Eweitz

Cited In

Organism

Rattus norvegicus

Communities

Annotations

Pathway Ontology: G protein mediated signaling pathway via Galpha12/Galpha13 family G protein mediated signaling pathway

Participants

Label Type Compact Identifier
Rtkn GeneProduct ensembl:ENSRNOG00000059679
Pkn1 GeneProduct ensembl:ENSRNOG00000004131
Cfl2 GeneProduct ensembl:ENSRNOG00000045892
Rhpn2 GeneProduct ensembl:ENSRNOG00000011885
Rhoa GeneProduct ensembl:ENSRNOG00000050519
Mk1 GeneProduct ensembl:ENSRNOG00000019657
Arhgef1 GeneProduct ensembl:ENSRNOG00000020130
Cyfip1 GeneProduct ensembl:ENSRNOG00000011945
Gna13 GeneProduct ensembl:ENSRNOG00000036745
Iqgap2 GeneProduct ensembl:ENSRNOG00000025406
Iqgap1 GeneProduct ensembl:ENSRNOG00000012002
Pik3cd GeneProduct ensembl:ENSRNOG00000016846
Arhgdib GeneProduct ensembl:ENSRNOG00000005809
LOC100910021 GeneProduct ensembl:ENSRNOG00000023622
Sh3rf1 GeneProduct ensembl:ENSRNOG00000010358
Limk1 GeneProduct ensembl:ENSRNOG00000001470
Mybph GeneProduct ensembl:ENSRNOG00000003336
Rac1 GeneProduct ensembl:ENSRNOG00000001068
Tnk2 GeneProduct ensembl:ENSRNOG00000001769
Pak3 GeneProduct ensembl:ENSRNOG00000004676
Pip4k2a GeneProduct ensembl:ENSRNOG00000016670
Mapk10 GeneProduct ensembl:ENSRNOG00000002079
AABR07013776.1 GeneProduct ensembl:ENSRNOG00000048082
Wasl GeneProduct ensembl:ENSRNOG00000006975
Pik3r2 GeneProduct ensembl:ENSRNOG00000019228
Ppp1cb GeneProduct ensembl:ENSRNOG00000004612
Was GeneProduct ensembl:ENSRNOG00000031058
Map3k4 GeneProduct ensembl:ENSRNOG00000017419
Myl1 GeneProduct ensembl:ENSRNOG00000013262
Cit GeneProduct ensembl:ENSRNOG00000001143
ARHGDIG GeneProduct None
Rock1 GeneProduct ensembl:ENSRNOG00000031092
Diaph1 GeneProduct ensembl:ENSRNOG00000019688
AABR07037536.1 GeneProduct ensembl:ENSRNOG00000056810
Cdc42 GeneProduct ensembl:ENSRNOG00000013536
Rps6kb1 GeneProduct ensembl:ENSRNOG00000003919
Rock2 GeneProduct ensembl:ENSRNOG00000004496
CFL1 GeneProduct None

References

  1. Neves SR, Ram PT, Iyengar R. G protein pathways. Science. 2002 May 31;296(5573):1636–9. PubMed Europe PMC Scholia