Ether lipid biosynthesis (WP5275)

Ether lipid biosynthesis in humans. Ether lipids (e.g. plasmalogens), are peroxisome-derived glycerophospholipids where the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether bond (single bond between carbon and oxygen atom). Ether lipids are used to form non-lamellar inverted hexagonal structures in model membranes (indicating they could facilitate membrane fusion processes). Lipid raft microdomains (cholesterol-rich membrane regions involved in cellular signaling) rely on ether lipids for their organization and stability. [PMID:28523433]. The pathway knowledge depicted in this model stems from Robert C. Murphy, who endorsed version [ WP5275_r123734].
last edited


Conroy lipids , Denise Slenter , Egon Willighagen , and Robert C. Murphy

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Homo sapiens



Pathway Ontology: lipid metabolic pathway ether lipid metabolic pathway Zellweger syndrome pathway classic metabolic pathway

Disease Ontology: rhizomelic chondrodysplasia punctata type 2 Zellweger syndrome rhizomelic chondrodysplasia punctata type 1 rhizomelic chondrodysplasia punctata type 5 rhizomelic chondrodysplasia punctata type 3 peroxisome biogenesis disorder 1A rhizomelic chondrodysplasia punctata


Label Type Compact Identifier
DG-O Metabolite lipidmaps:LMGL02020000
Acyl-CoA Metabolite lipidmaps:LMFA07050000
Alkyl-DHAP Metabolite lipidmaps:LMGP22020000
Fatty acid Metabolite lipidmaps:LMFA01010000
LPA Metabolite lipidmaps:LMGP10050000
Acyl-DHAP Metabolite lipidmaps:LMGP22010000
Coenzyme A Metabolite chebi:15346
LPA-O Metabolite lipidmaps:LMGP10060000
GalEAG Metabolite lipidmaps:LMGL050200A0
PC-O Metabolite lipidmaps:LMGP01020000
PE-O Metabolite lipidmaps:LMGP02020000
PA-O Metabolite lipidmaps:LMGP10020000
PE-P Metabolite lipidmaps:LMGP02030000
Fatty alcohol Metabolite lipidmaps:LMFA05000000
DHAP Metabolite chebi:16108
Seminolipid Metabolite lipidmaps:LMGL05020000
Acyl-CoA Metabolite lipidmaps:LMFA07050000
Coenzyme A Metabolite chebi:15346
Alkyl-DHAP Metabolite lipidmaps:LMGP22020000
Acyl-CoA Metabolite lipidmaps:LMFA07050000
Fatty Acid Metabolite chebi:57560
Fatty Alcohol Metabolite lipidmaps:LMFA05000000
Acyl-DHAP Metabolite lipidmaps:LMGP22010000
UNIDENTIFIED Protein eccode:
PexRAP Protein uniprot:Q6IAN0
ACS Protein eccode:
LPIN3 Protein uniprot:Q9BQK8
GNPAT Protein uniprot:O15228
PEX1 Protein uniprot:O43933
ARSA Protein uniprot:P15289
PEDS1 Protein uniprot:A5PLL7
LPCAT1 Protein uniprot:Q8NF37
AGPS Protein uniprot:O00116
PEX5L Protein uniprot:Q8IYB4
PEX7 Protein uniprot:O00628
GAL3ST1 Protein uniprot:Q99999
LPIN1 Protein uniprot:Q14693
UGT8 Protein uniprot:Q16880
LPIN2 Protein uniprot:Q92539
CEPT1 Protein uniprot:Q9Y6K0
FAR1 Protein uniprot:Q8WVX9
FAR2 Protein uniprot:Q96K12
AGPS Protein uniprot:O00116
PEX7 Protein uniprot:O00628
PEX3 Protein uniprot:P56589
PEX16 Protein uniprot:Q9Y5Y5
PEX19 Protein uniprot:P40855


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